Vasopressin and Animal Behavior

Gash, Don M.; Herman, James P.; Thomas, Garth J.

doi:10.1007/978-1-4615-8129-1_14

Cited by 17 publications

(6 citation statements)

References 140 publications

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“…In the rat, intracerebral injection of oxytocin has been shown to influence reproductive behaviors (27)(28)(29)(30). Our findings suggest that vasopressin, rather than oxytocin, might affect reproductive behaviors in the Siberian hamster and play, in this species, the role exerted by oxytocin in the rat (31)(32)(33)(34)(35)(36)(37).…”

Section: Discussionmentioning

confidence: 56%

Expression of vasopressin receptors in hamster hypothalamus is sexually dimorphic and dependent upon photoperiod.

Dubois‐Dauphin¹,

Théler²,

Zaganidis³

et al. 1991

Proc. Natl. Acad. Sci. U.S.A.

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The distribution of vasopressin receptors was studied in the brain of a photoperiodic animal, the Siberian In photoperiodic species, the activity of the gonads is modulated by the length of the daily light phase and by its chronicity over weeks. Thus, in spring and summertimeduring the long photoperiod (LP)-the Siberian hamster is sexually active, whereas in the short photoperiod (SP)-autumn and winter-its gonads atrophy, and the animals become sexually inactive. At the end of winter, the process is reversed and the gonads increase again in weight (1-3). Circulating gonadal steroids follow a parallel course: their level is lowered following shortening of the photoperiod, and this effect is reversed when the photoperiod increases again (4-8). These physiological modifications may be artificially induced in controlling the length of the photoperiod in animal husbandry (9). In the Siberian hamster, gonadal regression is directly under photoperiodic control: it is not dependent on the temperature or the amount offood available (1,2,10,11).In both male and female rats, oxytocin-binding sites in the hypothalamic ventromedial nucleus are down-regulated by castration, and they can be restored to precastration level by injections of sexual steroids (12-16). We investigated the distribution of vasopressin-and oxytocin-binding sites in the brain of male and female Siberian hamsters either in LP or SP conditions, using a newly developed gaseous detector of 13-particles (17) and film autoradiography. We discovered that in Siberian hamsters, vasopressin receptors rather than oxytocin receptors are present in the ventromedial hypothalamic nucleus and that they are expressed differentially in the male and in the female. Furthermore, the density of the binding was found to be dependent on photoperiod.MATERIAL AND METHODS Animals. Young adult Siberian hamsters (Phodopus sungorus) were maintained under either a LP (16/8-hr light/dark cycle) or a SP (8/16-hr light/dark cycle) for 10 weeks. Temperature was set at 20 ±+ 1C and humidity at 60-70o. The animals received tap water and food pellets ad libitum.Fourteen males (9 in LP, 5 in SP) and 11 females (7 in LP, 4 in SP) were used for the autoradiographic localization of vasopressin-and oxytocin-binding sites in the brain. Animals, 5 months old with a body weight of 30-50 g, were decapitated, and the testes were removed and weighed, or the uterus was inspected, to assess the activity of the gonads (2, 18). The brain was frozen in isopentane at -250C, and 15-I.m-thick coronal sections were cut in a cryostat, laid on gelatin/chromalum-coated slides, air-dried, and processed for light microscopic autoradiography.Autoradiography. Autoradiography of vasopressin-binding sites was performed as described (19) tTo whom reprint requests should be addressed. 11163The publication costs of this article were defrayed in part by page charge payment. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. §1734 solely to indicate this fact.

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Section: Discussionmentioning

confidence: 56%

Expression of vasopressin receptors in hamster hypothalamus is sexually dimorphic and dependent upon photoperiod.

Dubois‐Dauphin¹,

Théler²,

Zaganidis³

et al. 1991

Proc. Natl. Acad. Sci. U.S.A.

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“…Similarly, signaling by intestinal vagal afferents in response to hypo- and hypertonic fluids are known to influence vasopressin release (Baertschi and Pence, 1995; Stricker et al, 2002). Notably, thirst-promoting neurons in the subfornical organ (SFO), which are known to project to the SON (Gash and Boer, 1987), were recently shown to exhibit fast increases and decreases in activity in response to feeding and drinking, respectively (Zimmerman et al, 2016). However, in contrast to VP pp neurons, these SFO neurons did not respond to non-orofacial water-predicting cues, further supporting the existence of functionally diverse sources of pre-systemic input onto VP pp neurons.…”

Section: Discussionmentioning

confidence: 99%

Bidirectional Anticipation of Future Osmotic Challenges by Vasopressin Neurons

Mandelblat-Cerf

Kim

Burgess

et al. 2017

Neuron

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SUMMARY Ingestion of water and food are major hypo- and hyperosmotic challenges. To protect the body from osmotic stress, posterior pituitary-projecting, vasopressin-secreting neurons (VPpp neurons) counter osmotic perturbations by altering their release of vasopressin, which controls renal water excretion. Vasopressin levels begin to fall within minutes of water consumption, even prior to changes in blood osmolality. To ascertain the precise temporal dynamics by which water or food ingestion affect VPpp neuron activity, we directly recorded the spiking and calcium activity of genetically defined VPpp neurons. In states of elevated osmolality, water availability rapidly decreased VPpp neuron activity within seconds, beginning prior to water ingestion, upon presentation of water-predicting cues. In contrast, food availability following food restriction rapidly increased VPpp neuron activity within seconds, but only following feeding onset. These rapid and distinct changes in activity during drinking and feeding suggest diverse neural mechanisms underlying anticipatory regulation of VPpp neurons.

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“…The nature of the vasopressin effect in humans is still disputed. In animal research it has been agreed that vasopressin and its congeners improve performance in tests in which aspects of memory processes are measured (Gash and Thomas, 1984;De Wied, 1984;Gash et al, 1987). However, there is disagreement as to the nature of this effect.…”

Section: Discussionmentioning

confidence: 99%

Desglycinamide‐(Arg⁸)‐vasopressin in five trials with memory‐disturbed patients

Hijman

Jolles

Verhoeven

et al. 1992

Human Psychopharmacology

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A series of five consecutive clinical trials were performed in which the neuropeptide desglycinamide-(Arg*)-vasopressin (DGAVP) was administered to human subjects suffering from cognitive and memory complaints. The patients selected for the study were carefully screened with the aid of neuropsychological assessment procedures. The trials were conducted according to a structured design in which the variables 'dose', 'route of administration', 'treatment schedule', 'diagnostic group', and 'severity of deficit' were varied from trial to trial in order to find optimal conditions for the possible expression of a peptide effect, The results indicate a statistically significant effect of DGAVP on word list learning in patients with mild brain trauma, suggesting that learning performance and memory retrieval are improved after peptide treatment in these patients. Patients with more severe brain trauma did not respond to peptide treatment. Some DGAVP effects, e.g. increased speed of memory search, were observed in patients with age-associated memory deficits.

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Vasopressin and Animal Behavior

Cited by 17 publications

References 140 publications

Expression of vasopressin receptors in hamster hypothalamus is sexually dimorphic and dependent upon photoperiod.

Expression of vasopressin receptors in hamster hypothalamus is sexually dimorphic and dependent upon photoperiod.

Bidirectional Anticipation of Future Osmotic Challenges by Vasopressin Neurons

Desglycinamide‐(Arg⁸)‐vasopressin in five trials with memory‐disturbed patients

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Vasopressin and Animal Behavior

Cited by 17 publications

References 140 publications

Expression of vasopressin receptors in hamster hypothalamus is sexually dimorphic and dependent upon photoperiod.

Expression of vasopressin receptors in hamster hypothalamus is sexually dimorphic and dependent upon photoperiod.

Bidirectional Anticipation of Future Osmotic Challenges by Vasopressin Neurons

Desglycinamide‐(Arg8)‐vasopressin in five trials with memory‐disturbed patients

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Desglycinamide‐(Arg⁸)‐vasopressin in five trials with memory‐disturbed patients