Vasopressin binds to microvessels from rat hippocampus

Kretzschmar, R.; Landgraf, Rainer; Gjedde, Albert; Ermisch, A.

doi:10.1016/0006-8993(86)90229-5

Cited by 53 publications

(11 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…26 Phosphoinositol metabolism was altered by AVP infusion into brain. 27 Astrocytes grown from cortex and cerebellum have receptors for AVP that lead to the release of inositol phospholipids. 28 We have proposed that AVP caused the excessive stimulation of the AVP V] receptor, increasing calcium and sodium levels in the cell, 8 which is analogous to excitotoxic cell damage produced by excessive stimulation of the glutamate receptor.…”

Section: Resultsmentioning

confidence: 99%

Arginine vasopressin V1-antagonist and atrial natriuretic peptide reduce hemorrhagic brain edema in rats.

Rosenberg

Scremin

Estrada

et al. 1992

Stroke

View full text Add to dashboard Cite

Background and Purpose: Injection of arginine vasopressin into the cerebral ventricles in animals with brain injury increased brain water, whereas injection of atrial natriuretic peptide reduced water content. Therefore, to determine the role of endogenous arginine vasopressin in brain edema, we attempted to inhibit edema from a hemorrhagic lesion with an arginine vasopressin V t receptor antagonist or atrial natriuretic peptide.Methods: Adult Sprague-Dawley rats with hemorrhages induced by 0.4 IU bacterial collagenase were treated with 75 ng (n=9) or 8 jug (n=9) of the vasopressin Vi receptor antagonist

show abstract

Section: Resultsmentioning

confidence: 99%

Arginine vasopressin V1-antagonist and atrial natriuretic peptide reduce hemorrhagic brain edema in rats.

Rosenberg

Scremin

Estrada

et al. 1992

Stroke

View full text Add to dashboard Cite

show abstract

“…Oxytocin and vasopressin have been shown to affect the BBB permeability to 3H-orotic acid and an RNA precursor Oxytocin and repetitive behaviors in autism E Hollander et al in some brain regions (Landgraf et al, 1977(Landgraf et al, , 1978. Specific binding sites on capillary endothelial cells have been demonstrated for both peptides (Ermisch and Landgraf, 1990, Ermisch et al, 1988Kretzchmar et al, 1986), possibly affecting BBB permeability. In addition, and of more importance, the peptide may be binding to receptors in peripheral tissues, and since these targets feed back to the CNS, this may result in the observed changes in behavior.…”

Section: Discussionmentioning

confidence: 99%

Oxytocin Infusion Reduces Repetitive Behaviors in Adults with Autistic and Asperger's Disorders

Hollander

Novotny

Hanratty

et al. 2003

Neuropsychopharmacol

624

403

View full text Add to dashboard Cite

Autism is a neurodevelopmental disorder characterized by dysfunction in three core behavioral domains: repetitive behaviors, social deficits, and language abnormalities. There is evidence that abnormalities exist in peptide systems, particularly the oxytocin system, in autism spectrum patients. Furthermore, oxytocin and the closely related peptide vasopressin are known to play a role in social and repetitive behaviors. This study examined the impact of oxytocin on repetitive behaviors in 15 adults with autism or Asperger's disorder via randomized double-blind oxytocin and placebo challenges. The primary outcome measure was an instrument rating six repetitive behaviors: need to know, repeating, ordering, need to tell/ask, self-injury, and touching. Patients with autism spectrum disorders showed a significant reduction in repetitive behaviors following oxytocin infusion in comparison to placebo infusion. Repetitive behavior in autism spectrum disorders may be related to abnormalities in the oxytocin system, and may be partially ameliorated by synthetic oxytocin infusion.

show abstract

“…Moreover, because the Na + -H + antiporter is activated not only by acidosis and insulin but also by AVP (29), the high initial plasma AVP levels may further potentiate this mechanism and thus contribute to the subclinical brain edema present on admission. Regarding a potential, direct role for AVP in brain edema, AVP alters the permeability of the blood-brain barrier (30), and the AVP receptors have been demonstrated in the endothelium of brain capillaries (31). In this respect, it is interesting to note that patient 1, who developed clinical brain edema, had the highest plasma level of AVP on admission.…”

Section: Discussionmentioning

confidence: 99%

Correlates of Brain Edema in Uncontrolled IDDM

et al. 1992

View full text Add to dashboard Cite

Blood glucose, plasma sodium, bicarbonate (HCO3-), vasopressin, and hematocrit were monitored before and during treatment in patients with uncontrolled insulin-dependent diabetes mellitus (IDDM). These parameters were correlated with simultaneous serial cranial computed tomography readings of brain edema. Six of seven patients had positive computed tomography readings for brain edema on admission. Initial brain edema correlated directly with blood glucose (r = 0.79, P = 0.033) and inversely with HCO3- (r = -0.76, P = 0.047). At 6 h, brain edema still correlated with acidosis (HCO3-; r = -0.79, P = 0.033) but no longer with blood glucose. At that time, however, brain edema correlated with the rate of change in blood glucose (r = 0.915, P = 0.005). Results of interactive stepwise regression analysis suggest that the change in the calculated effective plasma osmolality plays a predominant role in the progression of brain edema during therapy (r = 0.995, P less than 0.001). Thus, although hyperglycemia and acidosis probably predispose to diabetic brain edema, osmotic factors may be major predictors of its evolution. No relationships were detected between brain edema and initiation of insulin therapy, plasma vasopressin, or changes in hematocrit. The factors responsible for initial brain edema and its progression, statistically identified in this study, require reassessment of common theories that attribute brain edema exclusively to therapy.

show abstract

Vasopressin binds to microvessels from rat hippocampus

Cited by 53 publications

References 21 publications

Arginine vasopressin V1-antagonist and atrial natriuretic peptide reduce hemorrhagic brain edema in rats.

Arginine vasopressin V1-antagonist and atrial natriuretic peptide reduce hemorrhagic brain edema in rats.

Oxytocin Infusion Reduces Repetitive Behaviors in Adults with Autistic and Asperger's Disorders

Correlates of Brain Edema in Uncontrolled IDDM

Contact Info

Product

Resources

About