Vasopressin increases [Ca2+]i in differentiated astrocytes by activation of V1b/V3 receptors but has no effect in mature cortical neurons

Chen, Ye; Zhao, Zhiqiang; Hertz, Leif

doi:10.1002/1097-4547(20000615)60:6<761::aid-jnr8>3.0.co;2-r

Cited by 14 publications

(2 citation statements)

References 49 publications

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“…121,122 Activation of V1bRs and V3Rs by AVP in primary rodent astrocytes in vitro results in Ca 2+ release from intracellular stores, whereas activation of V1aRs leads to increased Ca 2+ uptake from the extracellular space. 123 Both mechanisms result in increased glutamate release from astrocytes, leading to an increased extracellular glutamate concentration. 122,123 Although these studies were conducted in primary rodent astrocytes derived from the cortex and hippocampus, if hypothalamic astrocytes display a similar response, then this increased glutamate availability may be a mechanism by which AVP action on astrocytes modulates neurotransmission.…”

Section: A S Tro C Y Te S and The Neuroendo Crine Reg Ul Ati On Of mentioning

confidence: 99%

“…123 Both mechanisms result in increased glutamate release from astrocytes, leading to an increased extracellular glutamate concentration. 122,123 Although these studies were conducted in primary rodent astrocytes derived from the cortex and hippocampus, if hypothalamic astrocytes display a similar response, then this increased glutamate availability may be a mechanism by which AVP action on astrocytes modulates neurotransmission.…”

Section: A S Tro C Y Te S and The Neuroendo Crine Reg Ul Ati On Of mentioning

confidence: 99%

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Astrocytes in neuroendocrine systems: An overview

Macdonald

Robb

Morrissey

et al. 2019

J Neuroendocrinology

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A class of glial cell, astrocytes, is highly abundant in the central nervous system (CNS). In addition to maintaining tissue homeostasis, astrocytes regulate neuronal communication and synaptic plasticity. There is an ever‐increasing appreciation that astrocytes are involved in the regulation of physiology and behaviour in normal and pathological states, including within neuroendocrine systems. Indeed, astrocytes are direct targets of hormone action in the CNS, via receptors expressed on their surface, and are also a source of regulatory neuropeptides, neurotransmitters and gliotransmitters. Furthermore, as part of the neurovascular unit, astrocytes can regulate hormone entry into the CNS. This review is intended to provide an overview of how astrocytes are impacted by and contribute to the regulation of a diverse range of neuroendocrine systems: energy homeostasis and metabolism, reproduction, fluid homeostasis, the stress response and circadian rhythms.

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Section: A S Tro C Y Te S and The Neuroendo Crine Reg Ul Ati On Of mentioning

confidence: 99%

Section: A S Tro C Y Te S and The Neuroendo Crine Reg Ul Ati On Of mentioning

confidence: 99%

Astrocytes in neuroendocrine systems: An overview

Macdonald

Robb

Morrissey

et al. 2019

J Neuroendocrinology

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Involvement of non-neuronal brain cells in AVP-mediated regulation of water space at the cellular, organ, and whole-body level

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Astrocytic glycogenolysis: mechanisms and functions

Hertz

Song

et al. 2014

Metab Brain Dis

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Until the demonstration little more than 20 years ago that glycogenolysis occurs during normal whisker stimulation glycogenolysis was regarded as a relatively uninteresting emergency procedure. Since then, a series of important astrocytic functions has been shown to be critically dependent on glycogenolytic activity to support the signaling mechanisms necessary for these functions to operate. This applies to glutamate formation and uptake and to release of ATP as a transmitter, stimulated by other transmitters or elevated K(+) concentrations and affecting not only other astrocytes but also most other brain cells. It is also relevant for astrocytic K(+) uptake both during the period when the extracellular K(+) concentration is still elevated after neuronal excitation, and capable of stimulating glycogenolytic activity, and during the subsequent undershoot after intense neuronal activity, when glycogenolysis may be stimulated by noradrenaline. Both elevated K(+) concentrations and several transmitters, including the β-adrenergic agonist isoproterenol and vasopressin increase free cytosolic Ca(2+) concentration in astrocytes, which stimulates phosphorylase kinase so that it activates the transformation of the inactive glycogen phosphorylase a to the active phosphorylase b. Contrary to common belief cyclic AMP plays at most a facilitatory role, and only when free cytosolic Ca(2+) concentration is also increased. Cyclic AMP is not increased during activation of glycogenolysis by either elevated K(+) concentrations or the stimulation of the serotonergic 5-HT(2B) receptor. Not all agents that stimulate glycogenolysis do so by directly activating phophorylase kinase--some do so by activating processes requiring glycogenolysis, e.g. for synthesis of glutamate.

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Vasopressin increases [Ca2+]i in differentiated astrocytes by activation of V1b/V3 receptors but has no effect in mature cortical neurons

Cited by 14 publications

References 49 publications

Astrocytes in neuroendocrine systems: An overview

Astrocytes in neuroendocrine systems: An overview

Involvement of non-neuronal brain cells in AVP-mediated regulation of water space at the cellular, organ, and whole-body level

Astrocytic glycogenolysis: mechanisms and functions

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