Vasopressin increases human risky cooperative behavior

Brunnlieb, Claudia; Nave, Gideon; Camerer, Colin F.; Schosser, Stephan; Vogt, Bodo; Münte, Thomas F.; Heldmann, Marcus

doi:10.1073/pnas.1518825113

Cited by 70 publications

(54 citation statements)

References 50 publications

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“…Sokol-Hessner et al 2015, for example, show that propranolol, a beta-blocker, has an effect on loss aversion, but not on risk attitudes. While this is not the only study suggesting an impact of hormones on decision making (Brunnlieb et al, 2016), it does reveal that hormonal mechanisms potentially affect specific aspects of risk behavior.…”

Section: Discussionmentioning

confidence: 86%

It’s all about gains: Risk preferences in problem gambling.

Ring¹,

Probst²,

Neyse³

et al. 2018

Journal of Experimental Psychology: General

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Problem gambling is a serious socioeconomic problem involving high individual and social costs. In this article, we study risk preferences of problem gamblers including their risk attitudes in the gain and loss domains, their weighting of probabilities, and their degree of loss aversion. Our findings indicate that problem gamblers are systematically more risk taking and less sensitive toward changes in probabilities in the gain domain only. Neither their risk attitudes in the loss domain nor their degree of loss aversion are significantly different from the controls. Additional evidence for a similar degree of sensitivity toward negative outcomes is gained from skin conductance data-a psychophysiological marker for emotional arousal-in a threat-of-shock task. (PsycINFO Database Record

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Section: Discussionmentioning

confidence: 86%

It’s all about gains: Risk preferences in problem gambling.

Ring¹,

Probst²,

Neyse³

et al. 2018

Journal of Experimental Psychology: General

Self Cite

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“…Arginine vasopressin effects on human social cognition and behavior have been studied using intranasal AVP administration, which is believed to cross the blood–brain barrier ( 17 ). Most studies have been done in men, where intranasal AVP has been found to facilitate cooperation ( 18 , 19 ), enhance recognition of sexual cues ( 20 ), and enhance encoding of happy and angry faces ( 21 ). In addition, among both men and women, intranasal AVP increases empathic concern in those who received high levels of paternal warmth ( 22 ), as well as anxiety and skin conductance responses to angry faces ( 23 ).…”

Section: Introductionmentioning

confidence: 99%

Arginine Vasopressin Effects on Subjective Judgments and Neural Responses to Same and Other-Sex Faces in Men and Women

Rilling

Chen

et al. 2017

Front. Endocrinol.

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Arginine vasopressin (AVP) influences social and emotional behaviors across a wide range of species. In humans, intranasal AVP has been previously shown to alter physiological responses to and subjective judgments of same-sex faces in both men and women. The present study attempted to elucidate the neural mechanism for these effects by randomizing 40 healthy men and 40 healthy women to treatment with either 40 IU intranasal AVP or a saline placebo approximately 30 min before imaging their brain function with fMRI as they viewed same and other-sex faces. All subjects were also scanned a second time several days later with no treatment to evaluate the persistence of AVP effects over time. AVP acutely increased positive ratings of same-sex faces in women, with some evidence that these effects persisted until the second scan. While AVP had no acute effects on same-sex ratings in men, AVP increased positive ratings of same-sex faces several days later. On the other hand, AVP had no effect on other-sex face judgments in either sex. AVP modulation of brain function was focused on the nucleus accumbens (NAc) and the lateral septum, two reward processing areas involved in the formation of social bonds. AVP provoked acute increases in right NAc and bilateral lateral septum responses to female faces among men, with left lateral septum responses persisting over time while right NAc responses reversed over time. Finally, AVP modulated hypothalamic activation to faces in both men and women. The present study therefore indicates that intranasal AVP affects subjective ratings and neural responses to same and other-sex faces in men and women, with some effects persisting and others emerging over time. Future studies should investigate whether AVP effects are modulated by individual variables such as genotype, personality, or attachment style as previously reported for other nonapeptides.

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“…AVP selectively draws attention to sexual content in language ( 29 ) and increases empathic concern in both male and female subjects who had previously received high levels of warmth from their fathers ( 30 ). Intranasal AVP also facilitates cooperation in complex social decision tasks, effects that are dependent on sex, contexts of the task, and the personality of the individual ( 31 – 33 ).…”

Section: Introductionmentioning

confidence: 99%

Dose-Dependent and Lasting Influences of Intranasal Vasopressin on Face Processing in Men

et al. 2017

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Arginine vasopressin (AVP) and related peptides have diverse effects on social behaviors in vertebrates, sometimes promoting affiliative interactions and sometimes aggressive or antisocial responses. The type of influence, in at least some species, depends on social contexts, including the sex of the individuals in the interaction and/or on the levels of peptide within brain circuits that control the behaviors. To determine if AVP promotes different responses to same- and other-sex faces in men, and if those effects are dose dependent, we measured the effects of two doses of AVP on subjective ratings of male and female faces. We also tested if any influences persist beyond the time of drug delivery. When AVP was administered intranasally on an initial test day, 20 IU was associated with decreased social assessments relative to placebo and 40 IU, and some of the effects persisted beyond the initial drug delivery and appeared to generalize to novel faces on subsequent test days. In single men, those influences were most pronounced, but not exclusive, for male faces, whereas in coupled men they were primarily associated with responses to female faces. Similar influences were not observed if AVP was delivered after placebo on a second test day. In a preliminary analysis, the differences in social assessments observed between men who received 20 and 40 IU, which we suggest primarily reflect lowered social assessments induced by the lower dose, appeared most pronounced in subjects who carry what has been identified as a risk allele for the V1a receptor gene. Together, these results suggest that AVP’s effects on face processing, and possibly other social responses, differ according to dose, depend on relationship status, and may be more prolonged than previously recognized.

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Vasopressin increases human risky cooperative behavior

Cited by 70 publications

References 50 publications

It’s all about gains: Risk preferences in problem gambling.

It’s all about gains: Risk preferences in problem gambling.

Arginine Vasopressin Effects on Subjective Judgments and Neural Responses to Same and Other-Sex Faces in Men and Women

Dose-Dependent and Lasting Influences of Intranasal Vasopressin on Face Processing in Men

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