Vasopressin-independent mechanisms in controlling water homeostasis

Cheng, Carrie Y.Y.; Chu, Jessica; Chow, Billy K. C.

doi:10.1677/jme-08-0123

Cited by 28 publications

(17 citation statements)

References 76 publications

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“…Suggested by its newly discovered role in water homeostasis in mammals [48], [49], it is possible that the occurrence of SCTR in the Sarcopterygii lineage prior the emergence of tetrapods was used for the change from aquatic to terrestrial habitat. Due to its origin, the lfSCTR is still able to interact with and be activated by VIP and PACAP, possibly by retaining the VIP/PACAP recognition motifs (e.g.…”

Section: Discussionmentioning

confidence: 99%

Origin of Secretin Receptor Precedes the Advent of Tetrapoda: Evidence on the Separated Origins of Secretin and Orexin

et al. 2011

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At present, secretin and its receptor have only been identified in mammals, and the origin of this ligand-receptor pair in early vertebrates is unclear. In addition, the elusive similarities of secretin and orexin in terms of both structures and functions suggest a common ancestral origin early in the vertebrate lineage. In this article, with the cloning and functional characterization of secretin receptors from lungfish and X. laevis as well as frog (X. laevis and Rana rugulosa) secretins, we provide evidence that the secretin ligand-receptor pair has already diverged and become highly specific by the emergence of tetrapods. The secretin receptor-like sequence cloned from lungfish indicates that the secretin receptor was descended from a VPAC-like receptor prior the advent of sarcopterygians. To clarify the controversial relationship of secretin and orexin, orexin type-2 receptor was cloned from X. laevis. We demonstrated that, in frog, secretin and orexin could activate their mutual receptors, indicating their coordinated complementary role in mediating physiological processes in non-mammalian vertebrates. However, among the peptides in the secretin/glucagon superfamily, secretin was found to be the only peptide that could activate the orexin receptor. We therefore hypothesize that secretin and orexin are of different ancestral origins early in the vertebrate lineage.

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Section: Discussionmentioning

confidence: 99%

Origin of Secretin Receptor Precedes the Advent of Tetrapoda: Evidence on the Separated Origins of Secretin and Orexin

et al. 2011

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“…AVP regulates aquaporins in the nephron, with aquaporin‐2 particularly important to renal tubule water reabsorption. Aquaporin‐2 is also influenced by secretin and oxytocin [22,23].…”

Section: Determinants Of Voiding Frequencymentioning

confidence: 99%

Nocturia as a manifestation of systemic disease

2011

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What’s known on the subject? and What does the study add? Waking at night to pass urine, nocturia, is widely regarded as urological, but many medical conditions can be responsible. Overproduction of urine overnight on the frequency volume chart, “nocturnal polyuria”, is a key feature signifying possible contribution of systemic disease; renal, endocrine, neurological, or cardiovascular malfunction may be responsible. Failure to evaluate the potential medical basis risks poor treatment outcomes for a bothersome symptom. Inappropriately instigating surgical treatment, such as TURP, can lead to harm in a patient whose nocturia is caused by nocturnal polyuria. Global and nocturnal polyuria should be fully investigated, in case a potentially serious illness is responsible. Nocturia is commonly referred to urologists, but the mechanisms underlying the problem, together with the appropriate clinical assessment and management, may lie outside the ordinary scope of the specialty. Some serious conditions may manifest nocturia as an early feature, often as a consequence of nocturnal polyuria (NP). Voiding frequency is influenced by rate of urine output, reservoir capacity of the bladder, lower urinary tract (LUT) sensation and psychological response. Polyuria can result from polydipsia or endocrine dysfunction. NP can result from endogenous fluid and solute shifts, cardiovascular and autonomic disease, obstructive sleep apnoea, and chronic kidney disease. Nocturia without polyuria occurs in the presence of LUT pathology, pelvic masses and sleep disturbance. Drug intake can contribute to, or counteract, each of these problems. In assessing nocturia, clinicians need to consider an undiagnosed serious condition that may manifest nocturia as an early feature, or suboptimal management of a known condition. The frequency‐volume chart is a key tool in categorizing the basis of nocturia, identifying those patients with global polyuria or NP, for whom involvement of other specialties is often necessary for assessment and management. Treatment should be directed at the cause of the problem, with a view to improving long‐term health and health‐related quality of life. Simple steps should be undertaken by all patients, including improvement of the sleep environment and behaviour modification. Evaluation of treatment response requires objective data to corroborate subjective impressions. Some mechanisms of nocturia do not reliably improve with treatment, leading to refractory symptoms.

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“…For example, oxytocin, a neuropeptide that regulates social behaviors (Lukas and Neumann, 2013; Stoesz et al, 2013; Feldman et al, 2015), couples to both the cAMP and cGMP cascades (Cheng et al, 2009; Viero et al, 2010). Further, cAMP-response element binding protein (CREB) and exchange protein activated by cAMP (Epac) are required for various types of social behaviors (Bickle, 2008; Srivastava et al, 2012; Yang et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

PDE11A regulates social behaviors and is a key mechanism by which social experience sculpts the brain

et al. 2016

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Despite the fact that appropriate social behaviors are vital to thriving in one’s environment, little is understood of the molecular mechanisms controlling social behaviors or how social experience sculpts these signaling pathways. Here, we determine if Phosphodiesterase 11A (PDE11A), an enzyme that is restricted to the ventral hippocampal formation (VHIPP) and that breaks down cAMP and cGMP, regulates social behaviors. PDE11 wild-type (WT), heterozygous (HT), and knockout (KO) mice were tested in various social approach assays and gene expression differences were measured by RNA sequencing. The effect of social isolation on PDE11A4 compartmentalization and subsequent social interactions and social memory was also assessed. Deletion of PDE11A triggered age- and sex-dependent deficits in social approach in specific social contexts but not others. Mice appear to detect altered social behaviors of PDE11A KO mice, because C57BL/6J mice prefer to spend time with a sex-matched PDE11A WT vs. its KO littermate; whereas, a PDE11A KO prefers to spend time with a novel PDE11A KO vs. its WT littermate. Not only is PDE11A required for intact social interactions, we found that 1 month of social isolation vs. group housing decreased PDE11A4 protein expression specifically within the membrane fraction of VHIPP. This isolation-induced decrease in PDE11A4 expression appears functional because social isolation impairs subsequent social approach behavior and social memory in a PDE11A genotype-dependent manner. Pathway analyses following RNA sequencing suggests PDE11A is a key regulator of the oxytocin pathway and membrane signaling, consistent with its pivotal role in regulating social behavior.

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Vasopressin-independent mechanisms in controlling water homeostasis

Cited by 28 publications

References 76 publications

Origin of Secretin Receptor Precedes the Advent of Tetrapoda: Evidence on the Separated Origins of Secretin and Orexin

Origin of Secretin Receptor Precedes the Advent of Tetrapoda: Evidence on the Separated Origins of Secretin and Orexin

Nocturia as a manifestation of systemic disease

PDE11A regulates social behaviors and is a key mechanism by which social experience sculpts the brain

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