Vasopressin metabolites: A link between vasopressin and memory?

Reijmers, Leon G.; Ree, Jan M. van; Spraijt, Berry M.; Burbach, J. Peter H.; Wied, D. de

doi:10.1016/s0079-6123(08)61591-5

Cited by 22 publications

(5 citation statements)

References 56 publications

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“…In particular, several VP metabolites have been identified to greatly contribute to the observed VP effects in the central nervous system. In contrast to VP, very low doses of those VP metabolites (e.g., 1/1000 of pharmacological dose of VP), which have no peripheral effects, have been found to induce changes in the CNS (Burbach et al, 1983 ; Dietrich and Allen, 1997 ; Fujiwara et al, 1997 ; Reijmers et al, 1998 ). These data favor the hypothetical existence of a separate “receptor” for the VP metabolites distinct of the classical G-protein coupled VP and oxytocin receptors, although its identity has remained obscure.…”

Section: Discussionmentioning

confidence: 99%

Thirst Is Associated with Suppression of Habenula Output and Active Stress Coping: Is there a Role for a Non-canonical Vasopressin-Glutamate Pathway?

Zhang

Hernández

Vázquez-Juárez

et al. 2016

Front. Neural Circuits

108

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Water-homeostasis is a fundamental physiological process for terrestrial life. In vertebrates, thirst drives water intake, but the neuronal circuits that connect the physiology of water regulation with emotional context are poorly understood. Vasopressin (VP) is a prominent messenger in this circuit, as well as L-glutamate. We have investigated the role of a VP circuit and interaction between thirst and motivational behaviors evoked by life-threatening stimuli in rats. We demonstrate a direct pathway from hypothalamic paraventricular VP-expressing, glutamatergic magnocellular neurons to the medial division of lateral habenula (LHbM), a region containing GABAergic neurons. In vivo recording and juxtacellular labeling revealed that GABAergic neurons in the LHbM had locally branching axons, and received VP-positive axon terminal contacts on their dendrites. Water deprivation significantly reduced freezing and immobility behaviors evoked by innate fear and behavioral despair, respectively, accompanied by decreased Fos expression in the lateral habenula. Our results reveal a novel VP-expressing hypothalamus to the LHbM circuit that is likely to evoke GABA-mediated inhibition in the LHbM, which promotes escape behavior during stress coping.

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Section: Discussionmentioning

confidence: 99%

Thirst Is Associated with Suppression of Habenula Output and Active Stress Coping: Is there a Role for a Non-canonical Vasopressin-Glutamate Pathway?

Zhang

Hernández

Vázquez-Juárez

et al. 2016

Front. Neural Circuits

108

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“…The neuropeptides oxytocin (OT) and vasopressin (VP) were first identified as neurohormones in the hypothalamo-neurohypophysial system (HNS) (Bargmann and Scharrer, 1951;Du Vigneaud, 1954). These peptides are now known to act in other regions of the nervous system and to control complex behaviors (Reijmers et al, 1998;Insel and Young, 2001). Although OT and VP fibers can be found throughout the CNS, expression of the OT and VP genes occurs almost exclusively in the hypothalamus.…”

Section: Introductionmentioning

confidence: 99%

Regulatory Domains in the Intergenic Region of the Oxytocin and Vasopressin Genes that Control their Hypothalamus-Specific ExpressionIn Vitro

2003

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Previous studies of oxytocin (OT) and vasopressin (VP) cell-specific gene expression in the hypothalamus using transgenic mouse and rat models focused attention on the intergenic region (IGR) as the site of critical enhancer elements. In this study, we used organotypic slice-explant cultures of rat hypothalamus as in vitro models, and particle-mediated gene transfer (biolistics) transfection methods to identify critical DNA sequences in the IGR between the OT and VP genes responsible for hypothalamic-specific gene expression. Reducing the 5' flanking region in the mouse VP gene from 3.5 kbp to 288 bp did not alter the efficacy of its expression in hypothalamic slices. All subsequent VP constructs were based on this 288 bp VP gene construct with changes made only to the IGR. These studies, which used various constructs with OT and VP promoters driving enhanced green fluorescent protein reporter gene expression, demonstrated that the IGR is necessary for OT and VP gene expression in hypothalamic slices in vitro. The DNA sequences in the IGR responsible for both OT and VP gene expression were located in a 178 bp domain immediately downstream of exon 3 of the VP gene. In addition, another domain in the IGR, 430 bp immediately downstream of exon 3 of the OT gene, contained a positive regulatory element for OT gene expression in the hypothalamus. Alignment of the DNA sequences in the 178 and 430 bp domains reveals four common sequences (motifs) that may be candidates for the putative enhancers in the IGR that regulate OT and VP gene hypothalamic-specific expression.

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“…One of these vasopressin metabolites is VP4-8, which has effects similar to vasopressin on social and other types of memory (Popik et al 1991;Reijmers et al 1998). In contrast, vasopressin metabolites lack the peripheral vasopressor and antidiuretic activities of vasopressin (De Jong et al 1985).…”

Section: Introductionmentioning

confidence: 99%

Delayed effect of the vasopressin metabolite VP4-8 on the social memory of sexually naive male rats

et al. 2001

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Vasopressin metabolites: A link between vasopressin and memory?

Cited by 22 publications

References 56 publications

Thirst Is Associated with Suppression of Habenula Output and Active Stress Coping: Is there a Role for a Non-canonical Vasopressin-Glutamate Pathway?

Thirst Is Associated with Suppression of Habenula Output and Active Stress Coping: Is there a Role for a Non-canonical Vasopressin-Glutamate Pathway?

Regulatory Domains in the Intergenic Region of the Oxytocin and Vasopressin Genes that Control their Hypothalamus-Specific ExpressionIn Vitro

Delayed effect of the vasopressin metabolite VP4-8 on the social memory of sexually naive male rats

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