Vasopressin, oxytocin and neurophysins in the human brain and spinal cord

Jenkins, Janis H.; Ang, V. T. Y.; Hawthorn, J.; Rossor, Martin N.; Ll, Iversen

doi:10.1016/0006-8993(84)90656-5

Cited by 125 publications

(44 citation statements)

References 22 publications

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“…Our results show that most regions charted by autoradiography to contain receptors for these neuropeptides in the human brain are activated by both maternal and romantic love (Jenkins et al, 1984;Loup et al, 1991).…”

Section: Attachment and Oxytocinmentioning

confidence: 65%

“…Romantic love activated the hilum of the dentate gyrus/hippocampus and the hypothalamus, and maternal love the periaqueductal gray (PAG). Together, this comprises almost all of the regions critical for these attachment-mediating neuropeptides in the human brain, the major exceptions being the septal nucleus and the preoptic region, which were not detected in either study (Jenkins et al, 1984;Loup et al, 1991).…”

Section: Neurohomone Binding Sites and Lovementioning

confidence: 86%

“…Our results therefore constitute the first evidence that PAG may be specifically involved in human maternal (and not pairbonding) behavior. PAG receives direct connections from the limbic areas (including those activated here), and contains a high density of vasopressin and oxytocin receptors (Jenkins et al, 1984). It is also known to be involved in endogenous pain suppression during experience of intense emotional experiences such as childbirth, and recent evidence demonstrates that this is facilitated through oxytocinergic action (Lund et al, 2002).…”

Section: Attachment and Oxytocinmentioning

confidence: 86%

See 2 more Smart Citations

The neural correlates of maternal and romantic love

2004

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Section: Attachment and Oxytocinmentioning

confidence: 65%

Section: Neurohomone Binding Sites and Lovementioning

confidence: 86%

Section: Attachment and Oxytocinmentioning

confidence: 86%

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The neural correlates of maternal and romantic love

2004

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“…Previous fMRI studies [22,76] support the view that the PAG is involved in human maternal behavior. This structure is heavily connected with various limbic regions and contains a high density of oxytocin receptors [77]. Oxytocin is a hypothalamic neuropeptide that has been widely implicated in the regulation of positive social interactions, social bonding, and maternal responsiveness in several mammalian species, including humans [78].…”

Section: Discussionmentioning

confidence: 99%

Brainstem Activity Predicts Attachment-Related Anxiety

Kikuchi¹,

Matsutani²,

Mori³

et al. 2018

Neuropsychiatry

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Objective: Attachment security serves as a critical resource for individuals to preserve relationship quality. However, insecure attachment interrupts it and seriously influences mental/physical health. Therefore, it is important to clarify the correlations between brain activity and attachment-related anxiety and its avoidance. Methods:We investigated these correlations in healthy male subjects by using functional magnetic resonance imaging (fMRI) while they were viewing their partner.Results: The brain regions that were significantly activated for the partner vs. unknown females were the anterior cingulate cortex (ACC), posterior cingulate cortex (PCC), dorsal raphe nucleus (DRN), pontine raphe nucleus (PRN), and locus coeruleus (LC) in a whole-brain analysis. A region of interest (ROI) analysis showed that the DRN, periaqueductal grey (PAG), hypothalamus, anterior insula (AIC), substantia nigra/ventral tegmental area (SN/VTA), ACC, PCC and intraparietal sulcus (IPS) were significantly activated. Furthermore, activity in the DRN, SN/VTA, and LC negatively correlated with attachment-related anxiety.Conclusions: There were individual differences in the correlations between the brainstem activity and attachment-related anxiety, although brain activity in our subjects was more similar to that observed in long-term intense romantic love and maternal love compared to that in early-stage romantic love. These brainstem regions are the primary sites of neurotransmitters which modulate basic functions of survival, and also play key roles for maintenance of secure relationships with a partner. This finding might be useful to assessment of the risk of breakdowns by factors of the attachment style.

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“…The organisation of the neurones is similar to that in other mammals (12). Also oxytocin has been detected in several extrahypothalamic areas of the brain (13,14). Regulating agents for oxytocin (e.g.…”

Section: The Brainmentioning

confidence: 99%

Oxytocin in the human--regulation of derivations and destinations

Evans

1997

European Journal of Endocrinology

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Vasopressin, oxytocin and neurophysins in the human brain and spinal cord

Cited by 125 publications

References 22 publications

The neural correlates of maternal and romantic love

The neural correlates of maternal and romantic love

Brainstem Activity Predicts Attachment-Related Anxiety

Oxytocin in the human--regulation of derivations and destinations

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