Vasopressin Reduces Food Intake in Goats

Meyer, Andrea; Langhans, Wolfgang; Scharrer, E.

doi:10.1113/expphysiol.1989.sp003294

Cited by 53 publications

(27 citation statements)

References 34 publications

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“…In vertebrates, appetite‐inhibitory effects have been observed for AVT in birds and also for AVP in mammals . To our knowledge, this is the first study reporting the anorexigenic effect of AVT in fish.…”

Section: Discussionmentioning

confidence: 68%

Arginine Vasotocin Treatment Induces a Stress Response and Exerts a Potent Anorexigenic Effect in Rainbow Trout, Oncorhynchus mykiss

Gesto

Soengas

Rodrı́guez-Illamola

et al. 2014

J Neuroendocrinology

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The peptide arginine vasotocin (AVT), homologous to mammalian arginine vasopressin, is involved in many aspects of fish physiology, such as osmoregulation, regulation of biological rhythms, reproduction, metabolism or responses to stress, and the modulation of social behaviours. Because a decrease in appetite is a general response to stress in fish and other vertebrates, we investigated the role of AVT as a possible food intake regulator in fish. We used i.c.v. injections for central administration of AVT to rainbow trout (Oncorhynchus mykiss). In a first experiment, we evaluated the temporal response of food intake after AVT treatment. In a second experiment, we investigated the effects of central AVT administration on the response of typical stress markers (plasma cortisol, glucose and lactate), as well as brain serotonergic, noradrenergic and dopaminergic activity. In addition, the mRNA levels of genes involved in food intake regulation [neuropetide Y, pro-opiomelanocortin (POMC), cocaine- and amphetamine-regulated transcript (CART) and corticotrophin-releasing factor (CRF)] and in CRF- (CRF-binding protein) and AVT-signalling (pro-VT and AVT receptor), were also assessed after AVT treatment. Our results showed that AVT is a potent anorexigenic factor in fish. Increases of plasma cortisol and glucose after AVT treatment strongly suggest that AVT administration induced a stress response and that AVT action was mediated by hypothalamic-pituitary-interrenal axis activation, which was also supported by the increase of the serotonergic activity in trout telencephalon and hypothalamus. The increased hypothalamic levels of POMC and CART suggest that these peptides might have a role in the anorexigenic action of AVT, whereas the involvement of CRF signalling is unclear.

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Section: Discussionmentioning

confidence: 68%

Arginine Vasotocin Treatment Induces a Stress Response and Exerts a Potent Anorexigenic Effect in Rainbow Trout, Oncorhynchus mykiss

Gesto

Soengas

Rodrı́guez-Illamola

et al. 2014

J Neuroendocrinology

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“…It was recently reported that similar to Dsk , another neuropeptide Crustacean cardioactive peptide ( Ccap ), Drosophila vasopressin/oxytocin homologue, is also expressed in the insulin-producing cells [27]. Intriguingly we have evidence that Ccap is involved regulating meal size in adult Drosophila (M. Williams, unpublished observations), both vasopressin and oxytocin have been shown to regulate meal size in mammals [28]–[30] …”

Section: Discussionmentioning

confidence: 69%

Obesity-Linked Homologues TfAP-2 and Twz Establish Meal Frequency in Drosophila melanogaster

et al. 2014

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In all animals managing the size of individual meals and frequency of feeding is crucial for metabolic homeostasis. In the current study we demonstrate that the noradrenalin analogue octopamine and the cholecystokinin (CCK) homologue Drosulfakinin (Dsk) function downstream of TfAP-2 and Tiwaz (Twz) to control the number of meals in adult flies. Loss of TfAP-2 or Twz in octopaminergic neurons increased the size of individual meals, while overexpression of TfAP-2 significantly decreased meal size and increased feeding frequency. Of note, our study reveals that TfAP-2 and Twz regulate octopamine signaling to initiate feeding; then octopamine, in a negative feedback loop, induces expression of Dsk to inhibit consummatory behavior. Intriguingly, we found that the mouse TfAP-2 and Twz homologues, AP-2β and Kctd15, co-localize in areas of the brain known to regulate feeding behavior and reward, and a proximity ligation assay (PLA) demonstrated that AP-2β and Kctd15 interact directly in a mouse hypothalamus-derived cell line. Finally, we show that in this mouse hypothalamic cell line AP-2β and Kctd15 directly interact with Ube2i, a mouse sumoylation enzyme, and that AP-2β may itself be sumoylated. Our study reveals how two obesity-linked homologues regulate metabolic homeostasis by modulating consummatory behavior.

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“…Therefore, an osmotic effect is unlikely to underlie the response of vasopressin or oxytocin neurones to SCM ingestion in our experiments. There is little evidence for a role of vasopressin neurones in appetite control (43,44). The mechanisms underlying a potential role of vasopressin in appetite control remains unknown; unlike oxytocin neurones, SON vasopressin neurones do not appear to be innervated by NTS projections and are inhibited by the satiety signal CCK (28).…”

Section: Discussionmentioning

confidence: 96%

High-Sugar, but Not High-Fat, Food Activates Supraoptic Nucleus Neurons in the Male Rat

2017

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Oxytocin is a potent anorexigen and is believed to have a role in satiety signaling. We developed rat models to study the activity of oxytocin neurons in response to voluntary consumption or oral gavage of foods using c-Fos immunohistochemistry and in vivo electrophysiology. Using c-Fos expression as an indirect marker of neural activation, we showed that the percentage of magnocellular oxytocin neurons expressing c-Fos increased with voluntary consumption of sweetened condensed milk (SCM). To model the effect of food in the stomach, we gavaged anesthetized rats with SCM. The percentage of supraoptic nucleus and paraventricular nucleus magnocellular oxytocin-immunoreactive neurons expressing c-Fos increased with SCM gavage but not with gastric distention. To further examine the activity of the supraoptic nucleus, we made in vivo electrophysiological recordings from SON neurons, where anesthetized rats were gavaged with SCM or single cream. Pharmacologically identified oxytocin neurons responded to SCM gavage with a linear, proportional, and sustained increase in firing rate, but cream gavage resulted in a transient reduction in firing rate. Blood glucose increased after SCM gavage but not cream gavage. Plasma osmolarity and plasma sodium were unchanged throughout. We show that in response to high-sugar, but not high-fat, food in the stomach, there is an increase in the activity of oxytocin neurons. This does not appear to be a consequence of stomach distention or changes in osmotic pressure. Our data suggest that the presence of specific foods with different macronutrient profiles in the stomach differentially regulates the activity of oxytocin neurons.

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Vasopressin Reduces Food Intake in Goats

Cited by 53 publications

References 34 publications

Arginine Vasotocin Treatment Induces a Stress Response and Exerts a Potent Anorexigenic Effect in Rainbow Trout, Oncorhynchus mykiss

Arginine Vasotocin Treatment Induces a Stress Response and Exerts a Potent Anorexigenic Effect in Rainbow Trout, Oncorhynchus mykiss

Obesity-Linked Homologues TfAP-2 and Twz Establish Meal Frequency in Drosophila melanogaster

High-Sugar, but Not High-Fat, Food Activates Supraoptic Nucleus Neurons in the Male Rat

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