Vasopressin Use in the Support of Organ Donors: Physiological Rationale and Review of the Literature

Ouerd, Sofiane; Frenette, Anne Julie; Serri, Karim; D’Aragon, Frédérick; Bichet, Daniel G.; Charbonney, Emmanuel

doi:10.1097/cce.0000000000000907

Cited by 4 publications

(1 citation statement)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Terlipressin offers several advantages over catecholamines, including a more selective vasoconstrictive action, longer duration of effect, and potentially fewer adverse effects . [38] The comparison between terlipressin and catecholamine infusion in the management of vasodilatory shock has been the subject of increasing interest. While individual studies have provided insights into their relative efficacy, the heterogeneity of findings necessitates a comprehensive synthesis of the available evidence .…”

Section: Discussionmentioning

confidence: 99%

Comparison Between Terlipressin and Catecholamine Infusion in the Management of Vasodilatory Shock: A Meta-Analysis of Randomized Controlled Trials

Mahdy,

Abd El-Hamid,

Awad Eltahawy

et al. 2023

Benha Medical Journal

View full text Add to dashboard Cite

Vasodilatory shock is a grave sign of cardiovascular failure. The use of vasoactive infusions is indicated when fluid resuscitation fails to restore adequate arterial pressure and tissue perfusion. Therefore, the proper management of clinically diverse shock states necessitates thorough knowledge of the mechanisms of action of vasoconstrictor drugs. The aim of this study was to compare between Terlipressin and catecholamine infusion in the management of vasodilatory shock. Study design: Meta-analysis Methods: Online databases (PubMed, Embase, BioMed, and the Cochrane Central Register of Controlled trials) were utilized for randomized studies ever performed in humans with Terlipressin in any clinical setting. Results: Twelve trials were included, involving a total of 1063 patients. The risk of bias was low. The meta-analysis found that there was no significant reduction in mortality. There was a significant reduction in heart rate, a significant increase in cardiac index, SVRI and UOP. There was no significant change in the rest of the hemodynamic variables among the included studies (MAP, SVI, PAOP, MPAP, PVRI, LVSWI, RVSWI and RAP). There was a significant decrease in IDO2, a significant increase in pH and a significant decrease in BE. There was no significant change in PO2 and PCO2 among the studies. There was a significant reduction in serum lactate and hemoglobin, while no significant change was observed in INR. This meta-analysis showed no significance of Terlipressin over catecholamines in reducing mortality rates, however, terlipressin is associated with reduction of HR, increase in SVRI, reduction of serum lactate level and increase in UOP.

show abstract

Section: Discussionmentioning

confidence: 99%

Comparison Between Terlipressin and Catecholamine Infusion in the Management of Vasodilatory Shock: A Meta-Analysis of Randomized Controlled Trials

Mahdy,

Abd El-Hamid,

Awad Eltahawy

et al. 2023

Benha Medical Journal

View full text Add to dashboard Cite

show abstract

Donor’s seral creatinine as a predictor of early allograft dysfunction after liver transplantation: A retrospective cohort study with propensity score analysis

Taipov,

Wang,

Hou

et al. 2024

Preprint

View full text Add to dashboard Cite

Background: There are several risk factors for early allograft dysfunction (EAD) after donation after citizen death (DCD) liver transplantation. This study explored whether elevated donor’s seral creatinine increases the risk of EAD after DCD liver transplantation. Materials and Methods: The study enrolled 224 primary adult DCD liver transplantation recipients. Univariate and multivariate logistic regression analyses were performed, and receiver operating characteristic curves were constructed. Perioperative clinical and laboratory variables were assessed for their association with the prevalence of EAD using the inverse probability of treatment weighting (IPTW) and 1:3 propensity score (PS) matching (Group A, n=53; Group B, n=124) analysis. Results: Forty-eight recipients (21.4%) developed EAD. All cases were divided into two groups (Group 1 [donor’s seral creatinine > 170μmol/L, n = 55] and Group 2 [donor’s seral creatinine ≤ 170μmol/L, n = 169]). Multivariate logistic regression analyses revealed that the donor’s age >60 years old (OR 5.927, 95CI% 2.144-16.387, p=0.001), BMI >24 (OR 2.818, 95CI% 1.359-5.845, p=0.005), with hypertension (OR 2.308, 95%CI 1.086-4.902, p=0.030), ICU stay >7 days (OR 3.369, 95% CI 1.449-7.832, p=0.005), and seral creatinine >170 μmol/L (OR 2.841, 95%CI 1.309-6.164, p=0.008) were independent risk factors for EAD. Moreover, the donor’s seral creatine >170 μmol/L was associated with incidence of EAD after adjusting for IPTW (OR 2.714, 95%CI 1.407-5.234, p=0.003), and after 1:3 PS matching (34.0% vs 18.5%, OR 2.258, 95%CI 1.092-4.671, p < 0.05). Conclusions: Elevated donor’s seral creatinine increased the risk of postoperative EAD, which might be a novel predictor of EAD after DCD liver transplantation.

show abstract

High Blood Pressure and Impaired Brain Health: Investigating the Neuroprotective Potential of Magnesium

Alateeq,

Walsh,

Cherbuin

2024

IJMS

View full text Add to dashboard Cite

High blood pressure (BP) is a significant contributor to the disease burden globally and is emerging as an important cause of morbidity and mortality in the young as well as the old. The well-established impact of high BP on neurodegeneration, cognitive impairment, and dementia is widely acknowledged. However, the influence of BP across its full range remains unclear. This review aims to explore in more detail the effects of BP levels on neurodegeneration, cognitive function, and dementia. Moreover, given the pressing need to identify strategies to reduce BP levels, particular attention is placed on reviewing the role of magnesium (Mg) in ageing and its capacity to lower BP levels, and therefore potentially promote brain health. Overall, the review aims to provide a comprehensive synthesis of the evidence linking BP, Mg and brain health. It is hoped that these insights will inform the development of cost-effective and scalable interventions to protect brain health in the ageing population.

show abstract

Vasopressin Use in the Support of Organ Donors: Physiological Rationale and Review of the Literature

Cited by 4 publications

References 41 publications

Comparison Between Terlipressin and Catecholamine Infusion in the Management of Vasodilatory Shock: A Meta-Analysis of Randomized Controlled Trials

Comparison Between Terlipressin and Catecholamine Infusion in the Management of Vasodilatory Shock: A Meta-Analysis of Randomized Controlled Trials

Donor’s seral creatinine as a predictor of early allograft dysfunction after liver transplantation: A retrospective cohort study with propensity score analysis

High Blood Pressure and Impaired Brain Health: Investigating the Neuroprotective Potential of Magnesium

Contact Info

Product

Resources

About