Vasopressinergic Neurocircuitry Regulating Social Attachment in a Monogamous Species

Tickerhoof, Maria C.; Smith, A. R.

doi:10.3389/fendo.2017.00265

Cited by 17 publications

(10 citation statements)

References 89 publications

(168 reference statements)

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“…The treatment also decreased social interest toward novel conspecifics and the animals emitted more, but shorter, ultra-sound vocalization, indicating anxiety-like behavior. This is in accordance with the known role of AVP in social behavior [53,65].…”

Section: Micrornas In the Epigenetic Regulation Of Vasopressinsupporting

confidence: 91%

“…As mentioned above, AVP plays a crucial role in social behavior. It is one of the most important neuropeptides in the regulation of partner preference, biparental care of pups and selective aggression in socially monogamous prairie vole (Microtus ochrogaster) [65]. In this species, it has been confirmed that histone deacetylase has a direct effect on pair bonding [66].…”

Section: Histone Modifications and Vasopressinmentioning

confidence: 99%

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Epigenetic Modulation of Vasopressin Expression in Health and Disease

Török

Fazekas

Szabó

et al. 2021

IJMS

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Vasopressin is a ubiquitous molecule playing an important role in a wide range of physiological processes thereby implicated in the pathomechanism of many disorders. Its effect is well characterized through V2 receptors, which regulates the water resorption in kidney, while its vasoconstrictory effect through V1a receptor also received a lot of attention in the maintenance of blood pressure during shock. However, the most striking is its central effect both through the V1b receptors in stress-axis regulation as well as through V1a receptors regulating many aspects of our behavior (e.g., social behavior, learning and memory). Vasopressin has been implicated in the development of depression, due to its connection with chronic stress, as well as schizophrenia because of its involvement in social interactions and memory processes. Epigenetic changes may also play a role in the development of these disorders. The possible mechanism includes DNA methylation, histone modification and/or micro RNAs, and these possible regulations will be in the focus of our present review.

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Section: Micrornas In the Epigenetic Regulation Of Vasopressinsupporting

confidence: 91%

Section: Histone Modifications and Vasopressinmentioning

confidence: 99%

Epigenetic Modulation of Vasopressin Expression in Health and Disease

Török

Fazekas

Szabó

et al. 2021

IJMS

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“…For instance, OXT possesses a single receptor type, while AVP was found to have three different subtypes ( AVPR1a, AVPR1b, AVPR2) . With regard to implication in social behaviors, AVP has been associated with pair-bond formation in monogamous species (Tickerhoof and Smith, 2017 ), while evidences in literature suggest that OXT is more broadly related to prosocial functioning. Furthermore, these two neuropeptides and their receptor variants exert different sex-dependent effects during physiological responses to stressors (Moons et al, 2014 ), suggesting an intriguing topic that still needs to be explored in-depth.…”

Section: Discussionmentioning

confidence: 99%

A Review of Oxytocin and Arginine-Vasopressin Receptors and Their Modulation of Autism Spectrum Disorder

Cataldo

Azhari

Esposito

2018

Front. Mol. Neurosci.

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Oxytocin (OXT) and arginine-vasopressin (AVP) play a key regulatory part in social and affiliative behaviors; two aspects highly compromised in Autism Spectrum Disorder (ASD). Furthermore, variants in the adjacent oxytocin-vasopressin gene regions have been found to be associated with ASD diagnosis and endophenotypes. This review focuses mainly on common OXTr single nucleotide polymorphisms (SNPs), AVPR1a microsatellites and AVPR1b polymorphisms in relation to the development of autism. Although these genes did not surface in genome-wide association studies, evidence supports the hypothesis that these receptors and their polymorphisms are widely involved in the regulation of social behavior, and in modulating neural and physiological pathways contributing to the etiology of ASD. With a specific focus on variants considered to be among the most prevalent in the development of ASD, these issues will be discussed in-depth and suggestions to approach inconsistencies in the present literature will be provided. Translational implications and future directions are deliberated from a short-term and a forward-looking perspective. While the scientific community has made significant progress in enhancing our understanding of ASD, more research is required for the ontology of this disorder to be fully elucidated. By supplementing information related to genetics, highlighting the differences across male and female sexes, this review provides a wider view of the current state of knowledge of OXTr and AVPr mechanisms of functioning, eventually addressing future research in the identification of further risk factors, to build new strategies for early interventions.

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“…Within this network, there is a substantial evidence that arginine-vasotocin (AVT)/arginine vasopressin (AVP) and oxytocin (OT) neuropeptides have a significant influence on social behavior ( Albers, 2015 ). In humans, polymorphisms in the genes encoding oxytocin and vasopressin peptides and/or their respective target receptors have been associated with variation in social recognition ( Tobin et al, 2010 ), social attachment ( Tickerhoof and Smith, 2017 ), parental behavior ( Johnson and Young, 2017 ), affective disorders ( Surget and Belzung, 2008 ) and psychiatric phenotypes such as autism ( Cataldo et al, 2018 )…”

Section: Arginine Vasopressin and Oxytocin Within The Social Behavior Neural Networkmentioning

confidence: 99%

The neuroscience of social feelings: mechanisms of adaptive social functioning

Eslinger

Anders

Ballarini

et al. 2021

Neuroscience & Biobehavioral Reviews

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Social feelings have conceptual and empirical connections with affect and emotion. In this review, we discuss how they relate to cognition, emotion, behavior and well-being. We examine the functional neuroanatomy and neurobiology of social feelings and their role in adaptive social functioning. Existing neuroscience literature is reviewed to identify concepts, methods and challenges that might be addressed by social feelings research. Specific topic areas highlight the influence and modulation of social feelings on interpersonal affiliation, parent-child attachments, moral sentiments, interpersonal stressors, and emotional communication. Brain regions involved in social feelings were confirmed by meta-analysis using the Neurosynth platform for large-scale, automated synthesis of functional magnetic resonance imaging data. Words that relate specifically to social feelings were identfied as potential research variables. Topical inquiries into social media behaviors, loneliness, trauma, and social sensitivity, especially with recent physical distancing for guarding public and personal health, underscored the increasing importance of social feelings for affective and second person neuroscience research with implications for brain development, physical and mental health, and lifelong adaptive functioning.

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Vasopressinergic Neurocircuitry Regulating Social Attachment in a Monogamous Species

Cited by 17 publications

References 89 publications

Epigenetic Modulation of Vasopressin Expression in Health and Disease

Epigenetic Modulation of Vasopressin Expression in Health and Disease

A Review of Oxytocin and Arginine-Vasopressin Receptors and Their Modulation of Autism Spectrum Disorder

The neuroscience of social feelings: mechanisms of adaptive social functioning

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