“…We thank Bombardieri and Tsui 1 for their excellent comments and interest in our study. 2 We agree with Bombardieri and Tsui that the deterioration of microperfusion and possibly tissue oxygenation after phenylephrine administration in the “healthy” brain hemisphere 2 indicates that different vasopressors may also have a different influence on microperfusion and tissue oxygenation in the healthy anesthetized brain and should be further explored.…”