Vasoprotection by Dietary Supplements and Exercise: Role of TNF<i>α</i>Signaling

Zhang, Hanrui; Zhang, Cuihua

doi:10.1155/2012/972679

Cited by 20 publications

(18 citation statements)

References 55 publications

(54 reference statements)

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“…Several preventive and therapeutic options have been proposed to counteract these biochemical alterations, including, among others, dietary supplementation resulting in antioxidant effects, antioxidant vitamins, and administration of NSAIDs at low doses [26–29]. It has also recently been shown that a healthy diet and regular moderate physical exercise have antioxidant and anti-inflammatory effects, reducing the risk of chronic diseases or contributing to its treatment [30–32].…”

Section: Discussionmentioning

confidence: 99%

Tai Chi Exercise Increases SOD Activity and Total Antioxidant Status in Saliva and Is Linked to an Improvement of Periodontal Disease in the Elderly

Mendoza-Núñez

Hernández-Monjaraz

Santiago‐Osorio³

et al. 2014

Oxidative Medicine and Cellular Longevity

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The aim of this study was to determine the effect of Tai Chi on biological markers of oxidative stress in saliva and its relationship with periodontal disease (PD) in older adults. We carried out a quasi-experimental study with a sample of 71 sedentary volunteers with PD who were divided into a control group of 34 subjects and an experimental group of 37 subjects who performed Tai Chi 5 days a week for a period of 6 months. PD status was characterized using the Periodontal Disease Index (PDI). Superoxide dismutase (SOD), total antioxidant status (TAS), and TBARS levels of both groups were measured by spectrophotometric methods. In addition, inflammation markers (TNF-α, IL-1β, IL-6, IL-8, and IL-10) were measured by flow cytometry. We found a statistically significant increase in SOD activity (P < 0.001) and TAS concentration (P < 0.05), whereas levels of IL-1β were significantly lower (P < 0.01). Likewise, a statistically significant decrease in the PDI (P < 0.05) was observed in subjects who performed Tai Chi during a period of 6 months. Our findings suggest that the practice of Tai Chi has both antioxidant and anti-inflammatory effects that are linked to the improvement of PD in older adults.

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Section: Discussionmentioning

confidence: 99%

Tai Chi Exercise Increases SOD Activity and Total Antioxidant Status in Saliva and Is Linked to an Improvement of Periodontal Disease in the Elderly

Mendoza-Núñez

Hernández-Monjaraz

Santiago‐Osorio³

et al. 2014

Oxidative Medicine and Cellular Longevity

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“…Accumulating evidence suggests that TNF-a induces vascular inflammation, monocyte adhesion to endothelial cells, vascular oxidative stress, apoptosis, and atherogenic response and participates in the regulation of thrombosis and coagulation through NFjB, Sp1, JNK, p38, and STAT3 pathways. 33 Dietary supplements and exercise training decrease TNF-a production and ameliorate TNF-a-mediated pathological changes in vasculature. Thus, the inhibitory effects of dietary supplements, including fish oil, dietary fibers, and various natural products, as well as physical exercise on TNF-a production and TNF-a signaling may contribute to their vasoprotective properties.…”

Section: Discussionmentioning

confidence: 99%

Sulforaphane Inhibits TNF-α-Induced Adhesion Molecule Expression Through the Rho A/ROCK/NF-κB Signaling Pathway

Hung

Huang

Wang

et al. 2014

Journal of Medicinal Food

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Endothelial dysfunction is an early indicator of cardiovascular diseases. Increased stimulation of tumor necrosis factor-a (TNF-a) triggers the inflammatory mediator secretion of endothelial cells, leading to atherosclerotic risk. In this study, we investigated whether sulforaphane (SFN) affected the expression of intracellular adhesion molecule-1 (ICAM-1) in TNF-a-induced ECV 304 endothelial cells. Our data showed that SFN attenuated TNF-a-induced expression of ICAM-1 in ECV 304 cells. Pretreatment of ECV 304 cells with SFN inhibited dose-dependently the secretion of proinflammatory cytokines, such as interleukin (IL)-1b, IL-6, and IL-8. SFN inhibited TNF-a-induced nuclear factor-jB (NF-jB) DNA binding activity. Furthermore, SFN decreased TNF-a-mediated phosphorylation of IjB kinase (IKK) and IjBa, Rho A, ROCK, ERK1/ 2, and plasminogen activator inhibitor-1 (PAI-1) levels. Collectively, SFN inhibited the NF-jB DNA binding activity and downregulated the TNF-a-mediated induction of ICAM-1 in endothelial cells by inhibiting the Rho A/ROCK/NF-jB signaling pathway, suggesting the beneficial effects of SFN on suppression of inflammation within the atherosclerotic lesion.

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“…Quercetin exerts multiple biological effects -antioxidant, hypoglycemic, neuroprotective and anti-inflammatory -in T1DM (3,(10)(11)(12)(13)(14)(15)(16)(17). Recent research has demonstrated the beneficial effects of exercise training on preventing diabetic vascular compli-cations by reducing oxidative/nitrosative stress and inflammation (3,14,(18)(19)(20)(21)(22). Therefore, in the current study we evaluated the effects of combining quercetin treatment with moderate exercise training in preventing carotid artery injuries in diabetic rats through a reduction of glycemia and oxidative stress.…”

Section: Introductionmentioning

confidence: 99%

Vascular impact of quercetin administration in association with moderate exercise training in experimental type 1 diabetes

Chis

Socaciu

Moldovan

et al. 2019

Revista Romana De Medicina De Laborator

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Hyperglycemia and oxidative stress have a major role in the pathogenesis of diabetic vascular complications. In this study, we investigated the efficacy of combining quercetin treatment with moderate exercise training in reversing diabetes-induced oxidative stress and ultrasound modifications in rat carotid arteries. The diabetic Wistar rats were divided into sedentary groups and trained groups. The trained animals went through a regular moderate exercise by swimming (5 weeks). Some non-diabetic and diabetic rats were daily treated with quercetin (30 mg/kg, for 5 weeks). At the end of the study, the imaging evaluation required to assess the effects of diabetes on carotid arteries was performed by micro-ultrasound (MU). The diabetic rats presented atherosclerotic plaques, with an increase in the echogenicity of the carotid artery wall, carotid intima-media thickness (CIMT), and carotid wall thickness, while the diabetic trained rats treated with quercetin presented normal values of these parameters. Malondialde-hyde (MDA) levels, superoxide dismutase (SOD) antioxidant enzyme activity, reduced glutathione (GSH) levels and the reduced (GSH) to oxidized (GSSG) glutathione ratio were determined in the carotid artery tissue. Diabetes caused elevated MDA levels and a decrease in SOD activity, GSH levels and GSH/GSSG ratio in the carotid artery tissue. Treating diabetic rats with quercetin combined with moderate exercise training reversed all these oxidative stress parameters. Our results show that this combination, quercetin and moderate exercise training, can be a good treatment strategy for the vascular complications of diabetes by attenuating hyperglycemia-mediated oxidative stress.

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Vasoprotection by Dietary Supplements and Exercise: Role of TNFαSignaling

Cited by 20 publications

References 55 publications

Tai Chi Exercise Increases SOD Activity and Total Antioxidant Status in Saliva and Is Linked to an Improvement of Periodontal Disease in the Elderly

Tai Chi Exercise Increases SOD Activity and Total Antioxidant Status in Saliva and Is Linked to an Improvement of Periodontal Disease in the Elderly

Sulforaphane Inhibits TNF-α-Induced Adhesion Molecule Expression Through the Rho A/ROCK/NF-κB Signaling Pathway

Vascular impact of quercetin administration in association with moderate exercise training in experimental type 1 diabetes

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