Vasorelaxant and hypotensive effects of a hydroalcoholic extract from the fruits of Nitraria sibirica Pall. (Nitrariaceae)

Sénejoux, François; Girard, Christian; Aisa, Haji Akber; Bakri, Mahinur; Kerram, Parhat; Berthelot, Alain; Bévalot, Françoise; Demougeot, Céline

doi:10.1016/j.jep.2011.08.012

Cited by 36 publications

(16 citation statements)

References 32 publications

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“…In this study, animals receiving simultaneous administration of L-NAME and HSCE showed lower systolic blood pressure as compared with animals receiving only L-NAME. Similar data were reported for Nitraria sibirica (Senejouxa et al, 2012), Bidens pilosa (Bilanda et al, 2017), Ulmus wallichiana (Syeda et al, 2016), Antidesma thwaitesianum (Kukongviriyapan et al, 2015), plants with NO-mediated hypotensive effect. The in vitro studies using the MVB preparation pre-contracted by Phen also support that the vasorelaxant mechanism of lythrine is likely to be mediated by activation of NO release from vascular endothelium, since the removal of endothelial cells led to absence of the response to HSCE.…”

Section: Discussionsupporting

confidence: 86%

Evaluation of antihypertensive and vasorelaxant effects of Heimia salicifolia (family: Lythraceae)

Guzmán-Hernández¹,

Segura-Cobos²,

Amato³

et al. 2018

Afr. J. Pharm. Pharmacol.

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There are reports of the presence of vasodilatory alkaloids in Heimia salicifolia extracts. The action mechanisms of the potential antihypertensive effect of such alkaloids have not however, been elucidated. The objective of the present study was to corroborate the antihypertensive and vasorelaxant activities of the isolated alkaloids from H. salicifolia, and to characterize their vasorelaxant actions. A chloroform extract (HSCE) was obtained from H. salicifolia. The alkaloids were separated by thin layer chromatography, extracted from silica gel, and evaluated using spectroscopy. The alkaloid with the most potent vasorelaxant activity was identified as lythrine. The antihypertensive effect of the HSCE was corroborated on normotensive rats and on animals with N ω -nitro-L-arginine-methyl ester (L-NAME) induced hypertension. The action mechanisms of the HSCE and lythrine were studied on isolated and perfused rat mesenteric vascular bed (MVB) preparations. HSCE administration produced a concentration-dependent relaxation, but in preparations without vascular endothelium, the relaxant response to HSCE was significantly diminished. In MVB preparations with intact vascular endothelium, pre-contracted with phenylephrine or L-NAME, perfusion with lythrine produced concentrationdependent relaxation; a similar effect was produced by acetylcholine. Wortmannin (phosphatidylinositol 3-kinase inhibitor) and methylene blue (guanylate cyclase inhibitor) decreased the relaxant effect of lythrine. These data suggest that the vascular relaxation induced by alkaloids isolated from H. salicifolia is dependent on the activation of the nitric oxide/guanylate cyclase pathway.

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Section: Discussionsupporting

confidence: 86%

Evaluation of antihypertensive and vasorelaxant effects of Heimia salicifolia (family: Lythraceae)

Guzmán-Hernández¹,

Segura-Cobos²,

Amato³

et al. 2018

Afr. J. Pharm. Pharmacol.

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“…Studies have reported the involvement of polyphenols in endothelium-dependent relaxant effects mediated by the liberation of · NO and EDHF (Andriambeloson et al, 1997;De Moura et al, 2002;Ndiaye et al, 2003;De Moura et al, 2004). Senejoux et al (2012) demonstrated the possibility that polyphenolic compounds found in the extract of Nitraria sibirica Pall fruit are involved in its hypotensive properties and endothelium-dependent relaxation effects; these mainly involve · NO liberation, EDHF, and stimulation of the muscarinic receptors.…”

Section: Resultsmentioning

confidence: 99%

“…Several studies have demonstrated medicinal plants' effects on blood pressure by various mechanisms, such as increased release of · NO and EDHF (Rocha et al 2007;Victório et al, 2009a;Khan et al, 2012;Senejoux et al, 2012). The hydroalcoholic and aqueous extracts (De Moura et al, 1998) and essential oils (Victório, Kuster, Lage, 2009b;Barcelos et al, 2010) of the Alpinia zerumbet (Pers.)…”

Section: Introductionmentioning

confidence: 99%

Hypotensive effect and endothelium-dependent vascular action of leaves of Alpinia purpurata (Vieill) K. Schum

Silva

Lima

Caliman

et al. 2014

Braz. J. Pharm. Sci.

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The aims of this study were to evaluate the chemical profile, vascular reactivity, and acute hypotensive effect (AHE) of the ethanolic extract of leaves of Alpinia purpurata (Vieill) K. Schum (EEAP). Its chemical profile was evaluated using HPLC-UV, ICP-OES, and colorimetric quantification of total flavonoids and polyphenols. The vascular reactivity of the extract was determined using the mesenteric bed isolated from WKY. AHE dose-response curves were obtained for both EEAP and inorganic material isolated from AP (IAP) in WKY and SHR animals. Cytotoxic and mutagenic safety levels were determined by the micronucleus test. Rutin-like flavonoids were quantified in the EEAP (1.8 ± 0.03%), and the total flavonoid and polyphenol ratios were 4.1 ± 1.8% and 5.1 ± 0.3%, respectively. We observed that the vasodilation action of EEAP was partially mediated by nitric oxide ( ). The EEAP and IAP showed an AHE in WKY and SHR animals. EEAP did not have cytotoxic effects or cause chromosomic alterations. The AHE shown by EEAP could result from its endothelium-dependent vascular action. Rutin-like flavonoids, among other polyphenols, could contribute to these biological activities, and the calcium present in EEAP could act in a synergistic way.Uniterms: Alpinia. Alpinia purpurata/phytochemistry. Alpinia purpurata/ethanolic extract/vascular reactivity. Alpinia purpurata/ethanolic extract/acute hypotensive effect. Flavonoids/quantification. Polyphenols/quantification.Os objetivos deste estudo foram avaliar o perfil químico de folhas de Alpinia purpurata K. Schum (AP), assim como a reatividade vascular e o efeito hipotensor agudo (EHA) do extrato etanólico de folhas de AP (EEAP). Avliou-se o perfil químico utilizando-se HPLC-UV, ICP-OES e quantificação colorimétrica de flavonoides e polifenóis totais. A reatividade vascular foi determinada utilizando leito mesentérico isolado de ratos WKY. Curvas dose-resposta do EEAP e do material inorgânico da AP (IAP) foram realizadas em animais SHR e WKY. Determinaram-se a segurança citotóxica e mutagênica pelo teste de micronúcleos. Flavonoides tipo rutina foram quantificados no EEAP (1,8±0,03%) e flavonoide total e polifenóis foram de 4,1±1,8% e 5,1±0,3%, respectivamente. Observou-se ação vasodilatadora do EEAP, mediada parcialmente pelo óxido nítrico (

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“…On the other hand, it has also been effectively used in folklore medicines to treat disease including indigestion, neurasthenia, stomach, fever and cold [7][8][9]. In addition, the products of Nitraria fruits have played an essential role in the local soft drink market.…”

Section: Introductionmentioning

confidence: 99%

Chemical Composition of Three Nitraria Species Fruits

Yuan¹,

Sun²,

Yi³

et al. 2018

Asian J. Chem.

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In this study, the chemical compositions of fruits Nitraria roborowskii Kom., Nitraria sibirica Pall., Nitraria tangutorum Bobr. were investigated. The highest total flavonoids content were observed in Nitraria sibirica, which had the highest crude protein content (6.60 %), followed by Nitraria tangutorum (3.07%) and Nitraria roborowskii (2.65 %). The total sugar content of Nitraria species varied between 4.66 % and 5.31 %, total fat between 0.143 and 0.537 %, pH 3.81 and 4.29, respectively. Mineral compositions of the Nitraria species were 4530.2 mg/g Na, 3778.9 mg/g K, 681.0 mg/g Ca, 349.0 mg/g Mg, 301.8 mg/g P, 25.2 mg/g Fe, 4.3mg/g B, 2.6 mg/g Sr, 1.1 mg/g Co and 0.6 mg/g Cr.

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Vasorelaxant and hypotensive effects of a hydroalcoholic extract from the fruits of Nitraria sibirica Pall. (Nitrariaceae)

Cited by 36 publications

References 32 publications

Evaluation of antihypertensive and vasorelaxant effects of Heimia salicifolia (family: Lythraceae)

Evaluation of antihypertensive and vasorelaxant effects of Heimia salicifolia (family: Lythraceae)

Hypotensive effect and endothelium-dependent vascular action of leaves of Alpinia purpurata (Vieill) K. Schum

Chemical Composition of Three Nitraria Species Fruits

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