Vasorelaxant effect of the Lippia alba essential oil and its major constituent, citral, on the contractility of isolated rat aorta

Silva, R.E.R. da; Pereira-de-Morais, Luís; Silva, A.A.; Bastos, Carla M. S.; Pereira-Gonçalves, Átila; Kerntopf, Marta Regina; Menezes, Irwin Rose Alencar de; Leal‐Cardoso, J. H.; Barbosa, Roseli

doi:10.1016/j.biopha.2018.09.073

Cited by 28 publications

(22 citation statements)

References 45 publications

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“…Esses resultados mostraram-se reversíveis com a lavagem desse agente, evidenciando que o efeito apresentado não está relacionado com um efeito tóxico letal ao tecido. Em estudos anteriores foram relatadas atividade miorrelaxante de outras espécies do gênero Lippia (SILVA et al, 2018;BLANCO et al, 2013 ). Os resultados obtidos corroboram os dados encontrados por Carvalho et al (2018) onde foram testados o óleo essencial de Lippia alba e seus constituintes isolados, evidenciando relaxamento das contrações provocadas pela via eletromecânica (K+) em contraste com o baixa eficiência no relaxamento das contrações provocadas pela via do acoplamento farmacomecânico (ACh).…”

Section: Resultsunclassified

ATIVIDADE BRONCODILATADORA DO ÓLEO ESSENCIAL DE Lippia sidoides CHAM. EM BRONQUÍOLO ISOLADO DE Sus scrofa domesticus.

Pereira-de-Morais¹,

Silva²,

Silva³

et al. 2019

Blucher Biophysics Proceedings

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Section: Resultsunclassified

ATIVIDADE BRONCODILATADORA DO ÓLEO ESSENCIAL DE Lippia sidoides CHAM. EM BRONQUÍOLO ISOLADO DE Sus scrofa domesticus.

Pereira-de-Morais¹,

Silva²,

Silva³

et al. 2019

Blucher Biophysics Proceedings

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“…However, this chemical composition is sensibly dependent on the geographic location and the phenology of the plant material harvested (Durán, Monsalve, Martínez, & Stashenko, 2007), which has categorized L. alba in seven chemotypes (Table 1; Linde et al, 2016). Essential oils from chemotypes I and III plants present antispasmodic (Viana, Vale, Silva, & Matos, 2000;Blanco et al, 2013;Sousa et al, 2015;Silva et al, 2018;Carvalho et al, 2018), anticonvulsive (Fauth, Campos, Silveira, & Rao, 2002;Maynard et al, 2011), anxiolytic (Hatano,Torricelli,Giassi,Coslope,Fig. 1.…”

Section: Biological Activity Of L Alba Essential Oilsmentioning

confidence: 99%

Essential oils biological activity of the Lippia alba (Verbenaceae) shrub

Ortega-Cuadros

Guevara

Castillo

et al. 2020

RBT

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Introduction: Lippia alba is an aromatic species belonging to the Verbenaceae family. Its essential oils have been used in different industries, because of its biological properties. Objective: Identify the perspectives of the biotechnological applications of Lippia alba essential oils. Methodology: A scoping review was conducted on the biological activity of Lippia alba essential oils registered until October, 2018 in EBSCO, Embase, Scopus, and Lilacs databases. Results: Chemotypes I and III have been reported for different biological activities from the evaluations performed on microorganisms, fish, arthropods, small mammals, and cell lines; fundamentally associated with antibacterial, antifungal, cytotoxic, antioxidant, and sedative effects, among others. Records focused mainly on the health, fishing industry, and agrifood sectors. Conclusion: Studies on the effect of essential oil are promising, but do not reflect a continuity of the research toward prototypes or finished commercial products. Research groups must unify evaluation methodologies and include in all studies the relationship between phytochemical and biological activity for the meta-analyses to be possible. Likewise, they must join efforts through the National System for Agricultural Innovation (SNIA, for the term in Spanish) to generate finished products that impact upon society and facilitate progress in the country’s bio-economy.

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“…[28][29][30][31] Moreover, the helpful vascular effects including vasodilatory effect likely trough affecting the intracellular calcium concentration and nitric oxide pathway have been found for citral in isolated aorta. 15…”

Section: Effects Of Citral On Frap Valuementioning

confidence: 99%

“…10,14 Moreover, some beneficial cardiovascular effects due to antioxidant, radical scavenging, anti-inflammatory and vasodilatory properties have been reported for citral. 15,16 The present study aimed to investigate the possible protective effects of citral against oxidative damages induced by H2O2 in human umbilical vein endothelial cells (HUVECs).…”

Section: Introductionmentioning

confidence: 99%

Citral Protects Human Endothelial Cells against Hydrogen Peroxide-Induced Oxidative Stress

Safaeian¹,

Sajjadi²,

Montazeri³

et al. 2019

tjps

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Objectives: Oxidative stress has a major role in endothelial dysfunction. Citral is a monoterpene aldehyde with antioxidant properties. This study aimed to investigate the effect of citral on human umbilical vein endothelial cells (HUVECs) under hydrogen peroxide (H2O2)-induced oxidative stress. Materials and Methods: The cells were treated with citral (0.625-10 µg/ml) for 24h before exposure to H2O2 (0.5 mM, 2h). Cell viability was evaluated by 3-(4, 5-Dimethylthiazol-2-yl)-2, 5-diphenyl-tetrazolium bromide (MTT) assay. The hydroperoxide concentrations and ferric reducing ability of plasma (FRAP) were measured in intra-and extra-cellular fluids. Results: Pretreatment of HUVECs with citral at the concentrations of 5 and 10 µg/ml significantly enhanced the cell viability in H2O2-induced cytotoxicity. It reduced the intra-cellular hydroperoxides level at the concentrations of 5 and 10 µg/ml and the extra-cellular hydroperoxides level at the concentrations of 2.5-10 µg/ml. Pretreatment with citral significantly increased the FRAP value in intra-and extra-cellular fluids at the concentration range of 1.25-10 µg/ml. Conclusion: Antioxidant and cytoprotective effects were found for citral against oxidative damage induced by H2O2 in human endothelial cells. However, more studies in this area are needed to assess its clinical value for prevention and treatment of cardiovascular diseases.

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Vasorelaxant effect of the Lippia alba essential oil and its major constituent, citral, on the contractility of isolated rat aorta

Cited by 28 publications

References 45 publications

ATIVIDADE BRONCODILATADORA DO ÓLEO ESSENCIAL DE Lippia sidoides CHAM. EM BRONQUÍOLO ISOLADO DE Sus scrofa domesticus.

ATIVIDADE BRONCODILATADORA DO ÓLEO ESSENCIAL DE Lippia sidoides CHAM. EM BRONQUÍOLO ISOLADO DE Sus scrofa domesticus.

Essential oils biological activity of the Lippia alba (Verbenaceae) shrub

Citral Protects Human Endothelial Cells against Hydrogen Peroxide-Induced Oxidative Stress

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