Vasorelaxation induced by common edible tropical plant extracts in isolated rat aorta and mesenteric vascular bed

Runnie, Irine; Salleh, M.; Mohamed, Suhaila; Head, Richard; Abeywardena, Mahainda Y

doi:10.1016/j.jep.2004.03.019

Cited by 117 publications

(75 citation statements)

References 17 publications

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“…They appear to be able to regulate antioxidant enzyme gene transcription and intercellular signalling cascades involved in the regulation of cell growth, inflammation and many other processes (Stangeland et al 2009). Additionally, several reports have demonstrated that the phenolic compounds exhibit antioxidant, anti-inflammatory, anti-mutagenic, anticarcinogenic, anti-bacterial properties (Negi et al 2008;Fresco et al 2010) (Jeong et al 2010; Jayakumar and Kanthimathi 2011) and possess hypotensive actions (Eno et al 2000) which are in agreement with their vasorelaxant effects (Runnie et al 2004). …”

Section: Discussionmentioning

confidence: 86%

Prevention of cardiotoxicity of aflatoxin B1 via dietary supplementation of papaya fruit extracts in rats

2013

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The aim of the current study was to evaluate the cardioprotective ability of water (WE) and ethanolic (EE) papaya fruits extracts against cardiotoxicity induced by aflatoxin B 1 (AFB 1 ) in rats. Forty two female Sprague-Dawley rats were divided into six treatment groups and treated orally for 2 weeks as follow: control group, the group treated with WE (250 mg/kg b.w), the group treated with EE (250 mg/kg b.w), the group treated orally with AFB 1 (17 lg/kg b.w) and the groups treated orally with AFB 1 plus WE or EE. The results indicated that treatment with AFB 1 resulted in oxidative stress in the heart manifested by the marked increase in cardiac malondialdehyde and calcium levels accompanied with a significant decrease in cardiac total antioxidant capacity. Serum nitric oxide and sodium levels, lactate dehydrogenase and creatine kinase isoenzyme activities were significantly increased, whereas, cardiac Na ? /K ? -ATPase activity and serum potassium were insignificantly affected. Supplementation with WE or EE effectively ameliorated most of the changes induced by AFB 1 . It could be concluded that both extracts attenuated the oxidative stress induced in heart tissue by AFB 1 and WE was more pronounced due to the higher total phenolic contents than in the EE.

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Section: Discussionmentioning

confidence: 86%

Prevention of cardiotoxicity of aflatoxin B1 via dietary supplementation of papaya fruit extracts in rats

2013

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“…There are also preliminary studies reporting its blood pressure lowering and vasodilatory properties. However, the possible models of actions of cardiovascular activities are lacking (38). It is known that oxidative stresses, such as generation of damaging reactive oxygen species, will lead to cell death under ischemic condition.…”

Section: Discussionmentioning

confidence: 99%

Morinda Citrifolia (Noni) and Low Dose Aspirin Prevent Apoptotic Cell Death and Oxidative Stress on Isoproterenol Induced Myocardial Infarction in Rats

Ol¹,

Kanbak²,

İlhan³

et al. 2017

Erciyes Med J

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Objective: Isoproterenol (iso)-induced myocardial infarction is a widely used experimental model to study the beneficial effects of many drugs. Morinda citrifolia (noni) has traditionally been used for treating many diseases. Low-dose aspirin may have been protected heart tissueThis study aimed to investigate the possible protective effects of noni (20%) and low-dose aspirin (30 mg/kg) against iso-induced acute myocardial infarction in male Wistar rats. Materials and Methods:Rats were divided into control, iso, iso+noni, iso+aspirin, and iso+aspirin+noni groups (n=8). Myocardial infarction was induced by subcutaneous injection of iso (100 mg/kg) for two consecutive days. Iso-induced rats showed increased serum Creatine kinase-muscle brain CK-MB activity. The effects of noni (20%) and low-dose aspirin (30 mg/kg) were evaluated in response to iso-induced changes, Malondialdehyde (MDA), Superoxide Dismutase (SOD), Catalase (CAT), DNA fragmentation, caspase-3, and cathepsins B and L.Results: Oral treatment with 20% noni juice and low-dose aspirin (30 mg/kg) for 7 days significantly decreased apoptotic markers such as DNA fragmentation, caspase-3, and cathepsins B and L; increased antioxidant enzymes such as SOD and catalase activities; and decreased MDA levels. Conclusion:We propose that the protective effect, antiapoptotic and antioxidant mechanisms of noni and low dose aspirin may be on iso-induced myocardial infarction.

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“…citratus is used throughout many regions of the world as a medicinal plant. It has been claimed to be effective in reducing fever, infection, rheumatism, headaches and abdominal discomfort, as well as acting as sedative, analgesic, anti-inflammatory, antispasmodic, diuretic, carminative and antihypertensive agents (Borrelli and Izzo, 2000;Runnie et al, 2004).…”

Section: Citratus (Lemongrass) Is a Tropical Perennial Herb And Ismentioning

confidence: 99%

Spasmolytic effect of citral and extracts of Cymbopogon citratus on isolated rabbit ileum

Devi

Sim

Ismail

2011

J Smooth Muscle Res

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Cymbopogon citratus, commonly known as lemongrass, has been shown to have antioxidant, antimicrobial and chemo-protective properties. Citral, a monoterpenoid, is the major constituent of C. citratus that gives off a lemony scent and is postulated to be responsible for most of its actions. In addition, C. citratus has been traditionally used to treat gastrointestinal discomforts, however, the scientific evidence for this is still lacking. Thus, the aim of the present study was to investigate the effect of the extracts of various parts of C. citratus (leaves, stems and roots) and citral on the visceral smooth muscle activity of rabbit ileum. The effect of the test substances were tested on the spontaneous contraction, acetylcholine (ACh)-and KCl-induced contractions. Citral at doses between 0.061 mM to 15.6 mM and the extract of leaves at doses between 0.001 mg/mL to 1 mg/mL significantly reduced the spontaneous, ACh-and KCl-induced ileal contractions. When the ileum was incubated in K + -rich-Ca 2+ -free Tyrode's solution, it showed only minute contractions. However, the strength of contraction was increased with the addition of increasing concentrations of CaCl2. The presence of citral almost abolished the effect of adding CaCl2, while the leaf extract shifted the calcium concentration-response curve to the right, suggesting a calcium antagonistic effect. These results were similar to that elicited by verapamil, a known calcium channel blocker. In addition, the spasmolytic effect of citral was observed to be reduced by the nitric oxide synthase inhibitor, L-NAME. In conclusion, citral and the leaf extract of C. citratus exhibited spasmolytic activity and it appeared that they may act as calcium antagonists. Furthermore, the relaxant effect of citral, but not that of the leaf extract may be mediated by nitric oxide suggesting the presence of other chemical components in the leaf extract other than citral.

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Vasorelaxation induced by common edible tropical plant extracts in isolated rat aorta and mesenteric vascular bed

Cited by 117 publications

References 17 publications

Prevention of cardiotoxicity of aflatoxin B1 via dietary supplementation of papaya fruit extracts in rats

Prevention of cardiotoxicity of aflatoxin B1 via dietary supplementation of papaya fruit extracts in rats

Morinda Citrifolia (Noni) and Low Dose Aspirin Prevent Apoptotic Cell Death and Oxidative Stress on Isoproterenol Induced Myocardial Infarction in Rats

Spasmolytic effect of citral and extracts of Cymbopogon citratus on isolated rabbit ileum

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