2006
DOI: 10.1161/01.str.0000226995.27230.96
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Vasospasm and p53-Induced Apoptosis in an Experimental Model of Subarachnoid Hemorrhage

Abstract: Background and Purpose-Despite intensive research efforts, the etiology of vasospasm (sustained constriction of the cerebral vessels) remains unknown. In this study, we investigated the role of p53-induced apoptosis in the vasculature at 24 and 72 hours. To completely examine the apoptotic cascades, key proteins of the caspase-dependent, -independent and mitochondrial pathways were examined. Methods-In this study, adult rats were divided into 3 groups: sham (nϭ21), nontreatment (subarachnoid hemorrhage[SAH]ϩdi… Show more

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Cited by 97 publications
(85 citation statements)
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“…Horseradish peroxidase IEL Internal elastic lamina IL-1 and - 6 Interleukin 1 and 6 cJNK1/2 C-Jun N-terminal kinase 1/2 MMP-9…”
Section: -Hydroxy-3-methyl-glutaryl-coa Reductase Hrpmentioning
confidence: 99%
“…Horseradish peroxidase IEL Internal elastic lamina IL-1 and - 6 Interleukin 1 and 6 cJNK1/2 C-Jun N-terminal kinase 1/2 MMP-9…”
Section: -Hydroxy-3-methyl-glutaryl-coa Reductase Hrpmentioning
confidence: 99%
“…BCL2-related proteinA (BCL2A1), caspase8 (CASP8), and tumor necrosis factor receptor superfamily member 1A (TNFRSF1A) are included in this category (Supplementary Table 1). These findings suggest that several cell death pathways are activated in the arterial wall, causing apoptosis of endothelial cells and VSMCs during vasospasm as previously reported [35,36].…”
Section: Gene-related Functional Categories Dynamically Changed On Daysupporting
confidence: 86%
“…It is well documented that smooth muscle proliferation is related to endothelial cell death and detachment of the endothelium following SAH (3,22). We have shown here that SAH caused a significant increase in wall thickness.…”
Section: A B Csupporting
confidence: 64%