Vasotocin analogues with selective natriuretic, kaliuretic and antidiuretic effects in rats

Kutina, A. V.; Marina, A. S.; Ei, Shakhmatova; IuV, Natochin

doi:10.1016/j.regpep.2013.06.013

Cited by 10 publications

(15 citation statements)

References 45 publications

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“…the ability to intensify the excretion of osmotically active compounds, specifically, cations. Vasotocin analogs can be divided in three groups by their effect on the sodium and potassium ion transport in the kidney within this dose range [16]:…”

Section: Resultsmentioning

confidence: 99%

“…Vasopressin intensifies the reabsorption of sodium and magnesium ions in the thick ascending limb of Henle's loop [22] and, to lesser extent, in the distal convoluted tubules [7,23]. Previously, we have established that administration of desmopressin, the agonist of V 2 -receptors, at a dose of 0.05 nmol per 100 g of body mass decreases urinary magnesium excretion in rats [16]. The results of present investigation show that neurohypophysial hormones and their analogs, at doses stimulating mainly V 2 -receptors, also decrease urinary magnesium excretion.…”

Section: Discussionmentioning

confidence: 99%

“…Vasotocin administration to rats increases the solute-free water reabsorption in the kidneys and excretion of sodium, potassium and magnesium ions [12,13]. A series of vasotocin analogs having different effects on the renal transport of water and cations were synthesized [14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

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The effects of neurohypophysial nonapeptides and their analogs on magnesium excretion in rat kidney

Kutina

Karavashkina

Holasava

et al. 2014

J Evol Biochem Phys

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The effects of vertebrate neurohypophysial nonapeptides (vasopressin, vasotocin and their synthesized analogs) on urinary magnesium excretion were studied in rats. Neurohypophysial hormones and their analogs at doses stimulating V 2 -receptors (0.0001-0.001 nmol/100 g BM) exerted antidiuretic effect and reduced urinary magnesium excretion. At higher doses, activating V 2 and V 1a -receptors (0.025-0.1 nmol/100 g BW), vasotocin and its analogs (deamino-vasotocin (dAVT), deamino-Thr 4 -vasotocin, deamino-hArg 8 -vasotocin, deamino-monocarbo-vasotocin) enhanced excretion of magnesium and sodium ions. A direct relationship was revealed between the enhanced renal excretion of sodium and magnesium ions under these conditions. After the V 1аreceptor antagonist injection, dAVT caused a 10-fold lower increase in magnesium excretion. The V 2 -receptor antagonist did not affect dAVT-induced magniuresis. The data obtained suggest that V-receptors are involved in magnesium transport regulation in the rat kidney.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The effects of neurohypophysial nonapeptides and their analogs on magnesium excretion in rat kidney

Kutina

Karavashkina

Holasava

et al. 2014

J Evol Biochem Phys

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show abstract

“…Arginine vasotocin and especially the analogue desaminodextra-AVT induced strong natriuresis and kaliuresis in mammals as shown by studies performed on rat by Natochin group in St. Petersburg (11). These effects on sodium transport are independent of their antidiuretic activity, and are mediated by different subtypes of receptors V1A-subtypes-like (4,11).…”

Section: Arginine Vasotocin In Mammals: Strong Natriuretic Effectsmentioning

confidence: 99%

“…These effects on sodium transport are independent of their antidiuretic activity, and are mediated by different subtypes of receptors V1A-subtypes-like (4,11).…”

Section: Arginine Vasotocin In Mammals: Strong Natriuretic Effectsmentioning

confidence: 99%

Thyroid Advanced Carcinoma, Vaccine for T1D Diabetes, Vasotocine in Mammals as Natriuretic

Coculescu¹

2013

Acta Endo (Buc)

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New Approach to Calculation of Renal Cation Clearance in Rats after V1a Receptor Stimulation

Golosova

Natochin

2017

Bull Exp Biol Med

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V1a receptor agonist [Phe, Ile, Orn]-vasopressin produces maximum diuretic and saluretic effects in a dose of 0.1 nmol/100 g body weight: renal excretion of Na increases by 50 times in comparison with the initial level over 90 min, excretion of K, Mg, and Са increases by 3, 2, and 16 times, respectively. New formulas were proposed for calculation of the clearance considering total cation content in the extracellular fluid and the time of total effect of the injected dose. After injection of V1a receptors agonist, clearance of Na was 7% of its total content in the extracellular fluid, the corresponding values for K, Mg, and Ca were 63, 35, and 6%, respectively. The proposed approach differs significantly from the standard cation excretion evaluation and characterizes selective shifts in ion balance induced by physiologically active substances and possible side effects due to unbalanced loss of certain ions.

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Vasotocin analogues with selective natriuretic, kaliuretic and antidiuretic effects in rats

Cited by 10 publications

References 45 publications

The effects of neurohypophysial nonapeptides and their analogs on magnesium excretion in rat kidney

The effects of neurohypophysial nonapeptides and their analogs on magnesium excretion in rat kidney

Thyroid Advanced Carcinoma, Vaccine for T1D Diabetes, Vasotocine in Mammals as Natriuretic

New Approach to Calculation of Renal Cation Clearance in Rats after V1a Receptor Stimulation

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