Vat photopolymerization 3D printing of acid-cleavable PEG-methacrylate networks for biomaterial applications

Aduba, Donald C.; Margaretta, Evan; Marnot, Alexandra; Heifferon, Katherine V.; Surbey, Wyatt R.; Chartrain, Nicholas; Whittington, Abby R.; Long, Timothy Edward; Williams, Christopher B.

doi:10.1016/j.mtcomm.2019.01.003

Cited by 71 publications

(29 citation statements)

References 63 publications

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“…For example, by adding nanosilicates to PEGDTT, shear-thinning properties are tuned to allow 3D printing of PEG hydrogel as a bioink [172]. Concerning light-assisted methods, both PEGMA [173,175] and PEG-diacrylate (PEGDA) [176] when mixed with acid-cleavable crosslinkers and photoinitiators can be used to fabricate 3D PEG scaffolds.…”

Section: Polyethylene Glycol (Peg)mentioning

confidence: 99%

Engineered 3D Polymer and Hydrogel Microenvironments for Cell Culture Applications

2019

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The realization of biomimetic microenvironments for cell biology applications such as organ-on-chip, in vitro drug screening, and tissue engineering is one of the most fascinating research areas in the field of bioengineering. The continuous evolution of additive manufacturing techniques provides the tools to engineer these architectures at different scales. Moreover, it is now possible to tailor their biomechanical and topological properties while taking inspiration from the characteristics of the extracellular matrix, the three-dimensional scaffold in which cells proliferate, migrate, and differentiate. In such context, there is therefore a continuous quest for synthetic and nature-derived composite materials that must hold biocompatible, biodegradable, bioactive features and also be compatible with the envisioned fabrication strategy. The structure of the current review is intended to provide to both micro-engineers and cell biologists a comparative overview of the characteristics, advantages, and drawbacks of the major 3D printing techniques, the most promising biomaterials candidates, and the trade-offs that must be considered in order to replicate the properties of natural microenvironments.

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Section: Polyethylene Glycol (Peg)mentioning

confidence: 99%

Engineered 3D Polymer and Hydrogel Microenvironments for Cell Culture Applications

2019

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“…The swelling/deswelling capability of depends on the crosslinking ratio, the less cross-linked gel takes less time to swell than the more highly cross-linked gels. Reversible swelling and de-swelling of gels is a useful property for a variety of applications (e.g., coatings on medical devices) [38][39][40]. Consequently the ability of the organogels to reversibly swell/dry (using DCM as the organic solvent) were studied; similarly, we studied the ability of the hydrogels to reversibly swell/dry (using water), in both cases observing this to be reversible for five rounds of swelling/drying ( Figure A2).…”

Section: Gel Swelling In Various Solventsmentioning

confidence: 99%

Uptake and Release of Species from Carbohydrate Containing Organogels and Hydrogels

Pan

Roy

Haldar

et al. 2019

Gels

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Hydrogels are used for a variety of technical and medical applications capitalizing on their three-dimensional (3D) cross-linked polymeric structures and ability to act as a reservoir for encapsulated species (potentially encapsulating or releasing them in response to environmental stimuli). In this study, carbohydrate-based organogels were synthesized by reversible addition-fragmentation chain transfer (RAFT) polymerization of a β-D-glucose pentaacetate containing methacrylate monomer (Ac-glu-HEMA) in the presence of a di-vinyl cross-linker; these organogels could be converted to hydrogels by treatment with sodium methoxide (NaOMe). These materials were studied using solid state 13C cross-polarization/magic-angle spinning (CP/MAS) NMR, Fourier transform infrared (FTIR) spectroscopy, and field emission scanning electron microscopy (FE-SEM). The swelling of the gels in both organic solvents and water were studied, as was their ability to absorb model bioactive molecules (the cationic dyes methylene blue (MB) and rhodamine B (RhB)) and absorb/release silver nitrate, demonstrating such gels have potential for environmental and biomedical applications.

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“…If photopolymerization was traditionally devoted to the polymerization of coatings and adhesives due to the wavelength used during the pioneering works in photopolymerization (i.e. UV-light), [2][3][4] the scope of applications has recently been extended to emerging fields such as micro and nanoelectronics, 3D and 4D-printing [5][6][7][8][9][10][11]. Photopolymerization exhibits several appealing features compared to the traditional solution phase polymerization.…”

Section: Introductionmentioning

confidence: 99%

Recent advances on push–pull organic dyes as visible light photoinitiators of polymerization

Pigot

Noirbent

Brunel

et al. 2020

European Polymer Journal

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HAL is a multidisciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.

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Vat photopolymerization 3D printing of acid-cleavable PEG-methacrylate networks for biomaterial applications

Cited by 71 publications

References 63 publications

Engineered 3D Polymer and Hydrogel Microenvironments for Cell Culture Applications

Engineered 3D Polymer and Hydrogel Microenvironments for Cell Culture Applications

Uptake and Release of Species from Carbohydrate Containing Organogels and Hydrogels

Recent advances on push–pull organic dyes as visible light photoinitiators of polymerization

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