Vävnadsdistribution, utsöndring och metabolism för Heminevrin (4-metyl-5- β -kloretyltiazol-etandisulfonat)

Neonatal drug depression and respiratory distress managed by positive pressure ventilation and exchange transfusion.

“…It is known that chlormethiazole crosses the placenta (Duffus et al, 1968). More detailed studies in experimental animals have shown that the concentration of the drug in the fetal circulation approximately equals that of the maternal circulation within a few minutes after administration to the mother, and that its excretion is rapid and mainly renal (Allgen, Lindberg, and Ullberg, 1963). It is presumed that in the newborn infant reported here, renal function could not deal with the large dose of the drug, and prolonged depression of cerebral function resulted.…”