VCAN gene expression and its association with tumor stage and lymph node metastasis in colorectal cancer patients

Abstract

Introduction: Colorectal Cancer (CRC) is one of the most leading causes of cancer related mortalities and metastasis is the main cause of death in CRC patients. Versican (VCAN) is an Extra Cellular Matrix (ECM) proteoglycan that is involved in tumor progression and cancer metastasis. The overexpression of VCAN has been observed in some cancer. Objective: In this study we aimed to analyse VCAN gene expression in patients with colorectal cancer to

Expression of VCAN and its receptors in canine mammary carcinomas with or without myoepithelial proliferation

“…Our results revealed similarities in VCAN expression between the two histological tumor types evaluated, with greater staining found in the stroma adjacent to invasive carcinomatous cells in both types, corroborating previously published findings. Relatedly, associations between VCAN overexpression and tumor malignancy and aggressivity has also been demonstrated in human breast cancer (de Wit et al, 2017;Gorter et al, 2010;Touab et al, 2002;Hosseini et al, 2018;Skandalis et al, 2011) and canine mammary tumors (Erdélyi et al, 2003).…”

Inferring spatial transcriptomics markers from whole slide images to characterize metastasis-related spatial heterogeneity of colorectal tumors: A pilot study

“… 65 For the GAT model, these genes included: ACTA2, CDH11, 66 COL12A1, COL3A1, COL5A1, COL5A2, CTHRC1, 67 DCN, 68 FBLN1, GREM1, 69 ITGA5, 70 NNMT, 71 PCOLCE, POSTN, THBS1, THY1, TPM2, 72 and VCAN. 73 It is interesting to note that while the identified genes are tied to an E2M phenotype, only 2 of these genes ( PCOLCE and THBS1 ) were found in common between both methods. This suggests that each method may capture different molecular aspects of the E2M phenotype.…”

VCAN – A novel prognostic marker for gastric cancer

“…It has several active domains that influences its interactions with certain biological and pathological processes, and functions in extracellular matrix assembly and remodeling, anti-adhesion, as well as tumor cell proliferation, and migration (11). It is suggested to be involved in the development and progression of several malignancies due to its frequent expression in human cancers (12), and several studies have also validated its role in carcinogenesis -it is implicated in the pathogenesis of colorectal cancer, breast cancer, benign prostatic hyperplasia, skin cancer, oral squamous cell carcinoma, early-stage prostate cancer, and in leiomyomas, amongst others and associated with survival outcomes (11,(13)(14)(15)(16)(17)(18). However, its role in gastric cancer is not yet explained.…”