VCS parameters of neutrophils, monocytes and lymphocytes may indicate local bacterial infection in cancer patients who accepted cytotoxic chemotherapeutics

Zhou, Na; Liu, L.; Li, D.; Zeng, Qian; Song, Xinyu

doi:10.1007/s10096-015-2499-2

Cited by 7 publications

(7 citation statements)

References 20 publications

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“…Our results show changes in the volume of circulating immune cells, especially the increased mean neutrophil volume (MNV), mean monocyte volume (MMV), mean lymphocyte volume (MLV), and monocyte distribution width (MDW). This is consistent with recent studies on changes in leukocyte VCS parameters in the establishment of patients with cancer undergoing cytotoxic chemotherapy [14]. It has been shown that during acute bacterial infection, reactive and left-shifted neutrophils not only increase in number but also in volume [15], as shown above in the increase in MNV.…”

Section: Discussionsupporting

confidence: 92%

The Leukocyte VCS Parameters Compared with Procalcitonin, Interleukin-6, and Soluble Hemoglobin Scavenger Receptor sCD163 for Prediction of Sepsis in Patients with Cirrhosis

et al. 2019

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Background. Patients with liver cirrhosis have a high risk of sepsis and a poor prognosis. Recently, a new standard for sepsis (Sepsis-3) has been proposed in the general population. The Coulter Lh 750 hematology analyzer can evaluate mean volume, conductivity, scatter, and distribution width of leukocyte. We tried to use Sepsis-3 criteria to study the diagnostic value of volume, conductivity, and scattering (VCS) parameters in sepsis and infection in patients with liver cirrhosis compared with traditional infection markers (PCT, IL-6, sCDl63). Methods. A blinded, cohort study was conducted in three different ED populations within three affiliated hospitals. A total of 249 patients with liver cirrhosis were enrolled in the study. According to the "Sepsis-3" consensus criteria, clinical history, and laboratory examination, the subjects were divided into sepsis (n = 54), patients with infections (n = 95), and patients without systemic infections (n = 100). The blood samples of the patients were collected at the time of ED admission and were evaluated for the detection of sepsis. Results. The differences of MNV, MNS, MMV, MMS, MLV, NDW, and MDW in the three groups were statistically significant. In the diagnosis of sepsis in patients with liver cirrhosis, the sensitivity of combined detection of MMV and MDW was 88.89%; the specificity was 74%. This sensitivity was significantly better than the 83.3% achieved using 0.97 mg/L as the cutoff for sCD163. In the diagnosis of infection in cirrhosis, the sensitivity of combination of MNV and MMS was increased to 86.32%; the specificity was 92%. The sensitivity was the same as that achieved by using 0.31 ng/mL as the cutoff value of PCT, but the specificity increased. Conclusion. The leukocyte VCS parameter could be potential parameters for indicating sepsis and infection in patients with liver cirrhosis. The combined detection of MMV and MDW seemed to be helpful for the diagnosis of sepsis in these patients, and the combination of MNV and MMS could better indicate infection for them.

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Section: Discussionsupporting

confidence: 92%

The Leukocyte VCS Parameters Compared with Procalcitonin, Interleukin-6, and Soluble Hemoglobin Scavenger Receptor sCD163 for Prediction of Sepsis in Patients with Cirrhosis

et al. 2019

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“…Infection could cause a series of pathological change such as toxic vacuolization in cells to increase the complexity of cell internal structure, resulting in the increase of light scatter. 54 SIRS is closely related with immunological function change. Monocytes and lymphocytes are mainly types of cells in immune response, activation of monocytes and lymphocytes by SIRS, which can trigger cell death.…”

Section: Discussionmentioning

confidence: 99%

Leukocyte cell population data from the blood cell analyzer as a predictive marker for severity of acute pancreatitis

Wang

Zhou

et al. 2021

Clinical Laboratory Analysis

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Background The prediction for severe acute pancreatitis (SAP) is the key to give timely targeted treatment. Leukocyte cell population data (CPD) have been widely applied in early prediction and diagnosis of many diseases, but their predictive ability for SAP remains unexplored. We aim to testify whether CPD could be an indicator of AP severity in the early stage of the disease. Methods The prospective observational study was conducted in the emergency department ward of a territory hospital in Shanghai. The enrolled AP patients should meet 2012 Atlanta guideline. Results Totally, 103 AP patients and 62 healthy controls were enrolled and patients were classified into mild AP (n = 30), moderate SAP (n = 42), and SAP (n = 31). Forty‐two CPD parameters were examined in first 3 days of admission. Four CPD parameters were highest in SAP on admission and were constantly different among 3 groups during first 3 days of hospital stay. Eighteen CPD parameters were found correlated with the occurrence of SAP. Stepwise multivariate logistic regression analysis identified a scoring system of 4 parameters (SD_LALS_NE, MN_LALS_LY, SD_LMALS_MO, and SD_AL2_MO) with a sensitivity of 96.8%, specificity of 65.3%, and AUC of 0.87 for diagnostic accuracy on early identification of SAP. AUC of this scoring system was comparable with MCTSI, SOFA, APACHE II, MMS, BISAP, or biomarkers as CRP, PCT, and WBC in prediction of SAP and ICU transfer or death. Conclusions Several leukocyte CPD parameters have been identified different among MAP, MSAP, and SAP. They might be ultimately incorporated into a predictive system marker for severity of AP.

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“…Neutrophil VCS parameters have been used as an indicator of bacterial sepsis in recent years. [5][6][7][8] Chaves et al studied peripheral blood samples from 69 patients with positive blood cultures for bacteria and 35 control subjects. 5 They observed a significant increase in MNV and a significant decrease in MNS from septic patients compared with control subjects.…”

Section: Discussionmentioning

confidence: 99%

“…Some authors proposed that the morphologic changes seen in neutrophils in sepsis could be analysed by using the Coulter LH 750 with VCS technology. [5][6][7][8] The VCS technology of the Coulter LH 750 hematology analyser uses direct current impedance to measure cell volume of neutrophils, radio frequency opacity to measure conductivity for internal composition of neutrophils, and a laser beam to measure light scatter for cytoplasmic granularity and nuclear structure. 9,10 In real life setting, PT sometimes may be used in newborns with sepsis.…”

Section: Introductionmentioning

confidence: 99%

Effect of Phototherapy on Neutrophil VCS Parameters and White Blood Cells

Altuntaş

Doğan

Kışlal³

2019

J Coll Physicians Surg Pak

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VCS parameters of neutrophils, monocytes and lymphocytes may indicate local bacterial infection in cancer patients who accepted cytotoxic chemotherapeutics

Cited by 7 publications

References 20 publications

The Leukocyte VCS Parameters Compared with Procalcitonin, Interleukin-6, and Soluble Hemoglobin Scavenger Receptor sCD163 for Prediction of Sepsis in Patients with Cirrhosis

The Leukocyte VCS Parameters Compared with Procalcitonin, Interleukin-6, and Soluble Hemoglobin Scavenger Receptor sCD163 for Prediction of Sepsis in Patients with Cirrhosis

Leukocyte cell population data from the blood cell analyzer as a predictive marker for severity of acute pancreatitis

Effect of Phototherapy on Neutrophil VCS Parameters and White Blood Cells

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