VDR gene polymorphism at exon 2 start codon (<i>FokI</i>) may have influenced Type 1 diabetes mellitus susceptibility in two Spanish populations

Audı́, Laura; Martí, Gertrudis; Estéban, Cristina; Oyarzábal, Miren; Chueca, M.; Gussinyé, Miquel; Yeste, Diego; Fernández‐Cancio, Mónica; Andaluz, Pilar; Carrascosa, A.

doi:10.1111/j.1464-5491.2004.01126.x

Cited by 30 publications

(22 citation statements)

References 10 publications

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“…Although we cannot completely exclude the possibility of a minor role of these or others VDR alleles, for example as recently described Fok1 polymorphism [21], in our type 1 diabetics children, the present study does not suggest a major contribution of these VDR alleles to the disease in Chilean patients. …”

Section: Discussioncontrasting

confidence: 73%

Vitamin D receptor polymorphism and susceptibility to type 1 diabetes in chilean subjects: A case-parent study

et al. 2004

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Several reports have found a relation between polymorphisms of the vitamin D receptor gene (VDR) and the development of type 1 diabetes. We have examined the association of three VDR polymorphism with type 1 diabetes in 59 Chilean case-parents trios. Genotyping for Bsm1, Apal and Taq1 polymorphism were performed. Transmission/ disequiibrium tests were used to assess gene-disease associations through the evaluation of allelic transmission to affected offspring. Non-significant increased transmissions of B allele (probability of transmission = 52.5%, p = 0.69), A allele (probability of transmission = 58.4%, p = 0.17) and T allele (probability of transmission = 52.0%, p = 0.77) were estimated in Bsml, Apal and Taql sites, respectively. Haplotype-based analyses showed non-significant preferential transmissions (global p = 0.52). The present study does not support the hypothesis of a significant contribution of VDR alleles in the etiology of type 1 diabetes of Chilean cases.

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Section: Discussioncontrasting

confidence: 73%

Vitamin D receptor polymorphism and susceptibility to type 1 diabetes in chilean subjects: A case-parent study

et al. 2004

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“…The incidence of T1DM in SÄo Paulo is approximately eight in 100.000 inhabitants, similar to the proportion observed in Hungary and Spain [33]. Although a similar incidence of T1DM was observed in these countries, the same was not observed regarding the frequency of VDR FokI polymorphism (ff this study: 9%; Hungary, 17%; and Spain, 12%) [8,13]. Japan, as widely known, has one of the lowest incidences of T1DM in the world [33], but the frequency of polymorphism FokI (ff 11%) [34] was similar to that observed in the present study.…”

Section: Discussionsupporting

confidence: 50%

“…Previous publications showed a great range of VDR BsmI polymorphism frequencies on various populations [11][12][13][14][15]30]. Re- TDDM ϭ time of duration of diabetes; FCP ϭ fasting C-peptide.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of vitamin D receptor gene polymorphisms FokI and BsmI in Brazilian individuals with type 1 diabetes and their relation to β-cell autoimmunity and to remaining β-cell function

et al. 2009

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“…We reported no evidence of allelic or genotypic association of the FokI TϾC (rs10735810), BsmI AϾG (rs1544410), ApaI GϾT (rs7975232), or TaqI CϾT (rs731236) SNPs of the VDR gene with type 1 diabetes mellitus in our population. Such associations have been reported in populations from India [15], Taiwan [16], Germany [17][18][19], Hungary [14], Japan [20,21], the Netherlands [22], Croatia [23,24], Spain [25,26], and Chile [27]. However, no associations were detected in other populations from Brazil [28], Romania [29,30], Finland [30,31], Norway [30], the United States [30], and the United Kingdom [30].…”

Section: Discussionmentioning

confidence: 61%

Lack of association of vitamin D receptor gene polymorphisms with susceptibility to type 1 diabetes mellitus in the Portuguese population

et al. 2008

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The vitamin D receptor (VDR) gene is a candidate gene for susceptibility to autoimmune disorders. Association studies of VDR polymorphisms and risk of type 1 diabetes often produced conflicting results in different ethnic backgrounds. The aim of this study was to test for association between common VDR polymorphisms and the genetic susceptibility to type 1 diabetes in the Portuguese population. We genotyped 207 patients with type 1 diabetes and 249 controls for the FokI T>C (rs10735810), BsmI A>G (rs1544410), ApaI G>T (rs7975232), and TaqI C>T (rs731236) single nucleotide polymorphisms by polymerase chain reaction and restriction fragment length polymorphism analysis. The distribution of VDR genotype, allele, and haplotype frequencies did not differ significantly between patients and controls. These data suggest that the single nucleotide polymorphisms of the VDR gene are unlikely to contribute significantly to type 1 diabetes susceptibility in the Portuguese population.

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VDR gene polymorphism at exon 2 start codon (FokI) may have influenced Type 1 diabetes mellitus susceptibility in two Spanish populations

Cited by 30 publications

References 10 publications

Vitamin D receptor polymorphism and susceptibility to type 1 diabetes in chilean subjects: A case-parent study

Vitamin D receptor polymorphism and susceptibility to type 1 diabetes in chilean subjects: A case-parent study

Prevalence of vitamin D receptor gene polymorphisms FokI and BsmI in Brazilian individuals with type 1 diabetes and their relation to β-cell autoimmunity and to remaining β-cell function

Lack of association of vitamin D receptor gene polymorphisms with susceptibility to type 1 diabetes mellitus in the Portuguese population

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