VE-cadherin is a critical molecule for trophoblast?endothelial cell interaction in decidual spiral arteries

Bulla, Roberta; Villa, Antonello; Bossi, Fleur; Cassetti, Arianna; Radillo, Oriano; Spessotto, Paola; Seta, Francesco De; Guaschino, Secondo; Tedesco, Francesco

doi:10.1016/j.yexcr.2004.09.015

Cited by 47 publications

(50 citation statements)

References 46 publications

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“…65 Subsequently, VEcadherin was shown to facilitate the passage of endovascular trophoblasts across the endothelium. 74 Thus, the various cadherins play important roles in cell biology and particularly, also have important functions in placental biology.…”

Section: Downstream Gene Targets/cell-adhesion Molecules In Emtmentioning

confidence: 99%

Epithelial-mesenchymal transition during extravillous trophoblast differentiation

Davies

Pollheimer

Yong

et al. 2016

Cell Adhesion & Migration

216

146

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A successful pregnancy depends on the intricate and timely interactions of maternal and fetal cells. Placental extravillous cytotrophoblast invasion involves a cellular transition from an epithelial to mesenchymal phenotype. Villous cytotrophoblasts undergo a partial epithelial to mesenchymal transition (EMT) when differentiating into extravillous cytotrophoblasts and gain the capacity to migrate and invade. This review summarizes our current knowledge regarding known regulators of EMT in the human placenta, including the inducers of EMT, upstream transcription factors that control EMT and the downstream effectors, cell adhesion molecules and their differential expression and functions in pregnancy pathologies, preeclampsia (PE) and fetal growth restriction (FGR). The review also describes the research strategies that were used for the identification of the functional role of EMT targets in vitro. A better understanding of molecular pathways driven by placental EMT and further elucidation of signaling pathways underlying the developmental programs may offer novel strategies of targeted therapy for improving feto-placental growth in placental pathologies including PE and FGR.

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Section: Downstream Gene Targets/cell-adhesion Molecules In Emtmentioning

confidence: 99%

Epithelial-mesenchymal transition during extravillous trophoblast differentiation

Davies

Pollheimer

Yong

et al. 2016

Cell Adhesion & Migration

216

146

View full text Add to dashboard Cite

show abstract

“…Invasive trophoblasts up-regulate expression of VE-cadherin, platelet endothelial adhesion molecule (PECAM)-1, vascular cell adhesion molecule (VCAM)-1, the a4 integrins and a v b 3 integrin, which are typically expressed by the endothelium that they replace (Zhou et al 1997b). In vitro studies have shown the importance of these molecules in invasion and interactions with ECs (Bulla et al 2005). The a v b 3 integrins increase adhesion of trophoblasts to ECs, and a4 integrins bind to VCAM expressed by ECs.…”

Section: Factors Involved In Spiral Artery Remodellingmentioning

confidence: 99%

Remodelling at the maternal–fetal interface: relevance to human pregnancy disorders

Cartwright¹,

Fraser²,

Leslie³

et al. 2010

Reproduction

238

144

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In human pregnancy, successful placentation and remodelling of the uterine vasculature require the integration of a number of stages, which are crucial for a healthy pregnancy. As the demands of the developing fetus for nutrients and oxygen increase, the capacity of the maternal blood vessels to supply this must be altered radically, with deficiencies in this process implicated in a number of dangerous pregnancy complications. The complex signalling networks that regulate these tightly co-ordinated events are becoming clearer as more studies of early pregnancy are performed. It is the aim of this review to draw together our knowledge of events that occur to facilitate a successful pregnancy ranging from the preparation for implantation, through the invasion and differentiation of the trophoblast and the regulation of these processes by other cells within the decidual environment, to the active role that the trophoblast and maternal immune cells play in facilitating the remodelling of the uterine spiral arteries. The events involved in a healthy pregnancy will then be compared to aberrant placentation and remodelling, which are characteristics of many pregnancy disorders, and recent advances in detection of abnormal placental development will also be discussed.

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“…CTBs were purified from placental specimens postremoval of decidual tissue and fetal membrane as previously described (2). Briefly, placental tissue was incubated with HBSS containing 0.25% trypsin and 0.2 mg/ml DNase (Roche, Milano, Italy) for 20 min at 37˚C.…”

Section: Cell Isolation and Culturementioning

confidence: 99%

“…A characteristic feature of this interaction during placentation is the invasion of maternal decidua by fetal cytotrophoblasts (CTBs) that depart from the anchoring villi and migrate as extravillous trophoblasts (EVTs) into the maternal decidua, reaching the inner third of the myometrium (1). Some of the invading trophoblast cells penetrate the spiral arteries and migrate upward against blood flow, forming intravascular islands and mosaic vessels as a result of partial replacement of the endothelium (2,3). Trophoblast cells share with tumor cells the ability to invade tissues, with the major difference that trophoblast invasion is a physiological event strictly restricted to pregnancy and spatially limited to the decidual microenvironment (4)(5)(6)(7).…”

mentioning

confidence: 99%

An Alternative Role of C1q in Cell Migration and Tissue Remodeling: Contribution to Trophoblast Invasion and Placental Development

Agostinis

Bulla²,

Tripodo

et al. 2010

The Journal of Immunology

140

132

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VE-cadherin is a critical molecule for trophoblast?endothelial cell interaction in decidual spiral arteries

Cited by 47 publications

References 46 publications

Epithelial-mesenchymal transition during extravillous trophoblast differentiation

Epithelial-mesenchymal transition during extravillous trophoblast differentiation

Remodelling at the maternal–fetal interface: relevance to human pregnancy disorders

An Alternative Role of C1q in Cell Migration and Tissue Remodeling: Contribution to Trophoblast Invasion and Placental Development

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