Vector-borne diseases

Sharma, Satyavan

doi:10.1007/978-3-0348-7133-4_8

Cited by 6 publications

(8 citation statements)

References 272 publications

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“…It acts as a nonhumoral immunostimulant in immunosuppressed individuals. However, the mechanism of this stimulation is unknown [71,100,101]. N N S Fig.…”

Section: Levamisolementioning

confidence: 95%

“…Suramin has been shown to be moderately active against adult W. bancrofti and B. phahangi [70] but it has no effect on microfilariae and therefore it does not interrupt the transmission cycle in the short term. It is also relatively more toxic than other antifilarial drugs and is not widely used today [71]. Moreover levamisole has been shown to limit activity against filarial parasites [72].…”

Section: Chemotherapymentioning

confidence: 99%

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Recent Developments in Search of Antifilarial Agents

Tripathi¹,

Katiyar²,

Dwivedi³

et al. 2006

CMC

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Filariasis, caused by spirunid nematodes, is one of the most prevalent diseases of tropical and subtropical countries and encompasses a number of different pathological conditions. It has great impact on the socioeconomic conditions of the people affected with this disease. The most common type of filariasis is a lymphatic filariasis caused by a parasite that lives in human lymph system. Like malaria, it is also caused by mosquito bites. The life cycle of the parasite, pathogenesis and diagnosis of filariasis have been briefly reviewed here in. Different strategies to control this disease have been discussed with major emphasis on the mechanisms, merits and demerits of the existing drugs and the drugs under pipeline. New antifilarial prototypes discovered recently and finally the future perspective to control the disease have also been elucidated.

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“…It acts as a nonhumoral immunostimulant in immunosuppressed individuals. However, the mechanism of this stimulation is unknown [71,100,101]. N N S Fig.…”

Section: Levamisolementioning

confidence: 95%

Section: Chemotherapymentioning

confidence: 99%

Recent Developments in Search of Antifilarial Agents

Tripathi¹,

Katiyar²,

Dwivedi³

et al. 2006

CMC

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“…In the absence of antifilarial vaccines, Chemotherapy remains the mainstay for the treatment of the disease [2]. The age old drug diethylcarbamazine (DEC) removes almost all the microfilariae from blood stream but has lethal side effects [3]. Ivermectin, a semi synthetic drug is highly effective in reducing microfilariae but it does not completely kill the adult filarial worms [4].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of 4-amino-5-cyano-2, 6-Disubstituted Pyrimidines as a Potential Antifilarial DNA Topoisomerase II Inhibitors

Kumar¹,

Saxena²,

Chauhan

2008

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A novel series of 4-amino-5-cyano-2, 6-disubstituted pyrimidines have been synthesized and evaluated for their in vitro antifilarial DNA topoisomerase II activity against filarial parasite Setaria Cervi. In particular compounds bearing 4-chloro-phenyl substitutent at position-6, exhibited strong inhibition at 40 microg/mL and 5 microg/mL concentration. The present study based on the biological results obtained, suggests that the nature of substitutent at position-4 in the phenyl ring directly affects DNA topoisomerase II inhibitory activity. Most of the compounds have shown better topoisomerase II inhibitory activity than the standard antifilarial drug (DEC) and the topoisomerase II inhibitors (Novobiocin, Nalidixic acid).

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“…On the other hand, the effect of DEC on adult filarial parasites is limited. A large number of benzimidazole 2-carbamates show macrofilaricidal activity by the peritoneal route but suffers from various drawbacks (Sharma, 1990;Campbell, 1985).…”

Section: Introductionmentioning

confidence: 99%

In vivo antifilarial activity of some cyclic and acylic alcohols

Agarwal

Awasthi

Murthy³

2010

Med Chem Res

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The filarial nematodes, Wuchereria bancrofti, Brugia malayi, and Brugia timori are the causative agents of lymphatic filariasis. 2-Substituted propanol, cyclohexanol, and cyclooctanol compounds were evaluated for microfilaricidal and macrofilaricidal activity in vivo against Acanthocheilonema viteae and Litomosoides carinii in rodents. In the cyclohexanol series, 2-(piperidin-1-yl) cyclohexanol (2b) showed 88.9% macrofilaricidal activity against A. viteae in vivo, while cyclooctanol series, 2-(4-benzyl piperdin-1-yl) cyclooctanol (2f) showed 100% macrofilaricidal activity against A. viteae. Further, compounds 1-(furan-2-ylamino) ethanol (4a) and 1-(4-benzylpiperidin-1-yl)-ethyl acetate (5b) showed 81.3% and 83.4% macrofilaricidal activity, respectively, against the same parasite. Interestingly, compounds 2f and 4a showed significant sterilization of female worms in A. viteae. However, these compounds were found inactive against L. carinii. Therefore, the new class of compounds appeared to have promising antifilarial activity.

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Vector-borne diseases

Cited by 6 publications

References 272 publications

Recent Developments in Search of Antifilarial Agents

Recent Developments in Search of Antifilarial Agents

Synthesis of 4-amino-5-cyano-2, 6-Disubstituted Pyrimidines as a Potential Antifilarial DNA Topoisomerase II Inhibitors

In vivo antifilarial activity of some cyclic and acylic alcohols

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