Vector control intervention towards interruption of transmission of Chagas disease by Rhodnius prolixus, main vector in Guatemala

Hashimoto, Ken; Álvarez, Hernández; Nakagawa, Jun; Juárez, Jaime; Monroy, Carlota; Cordón-Rosales, Celia; Gil, Enrique

doi:10.1590/s0074-02762012000700007

Cited by 21 publications

(22 citation statements)

References 13 publications

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“…In Central America, a Chagas disease control initiative was launched in 2001 based largely on indoor residual spraying with insecticides [5]. Entomological surveys at the Municipality geopolitical level were performed in Guatemala to determine vector distribution.…”

Section: Introductionmentioning

confidence: 99%

Ecological, Social and Biological Risk Factors for Continued Trypanosoma cruzi Transmission by Triatoma dimidiata in Guatemala

et al. 2014

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BackgroundChagas disease transmission by Triatoma dimidiata persists in Guatemala and elsewhere in Central America under undefined ecological, biological and social (eco-bio-social) conditions.MethodologyEco-bio-social risk factors associated with persistent domiciliary infestation were identified by a cross-sectional survey and qualitative participatory methods. Quantitative and qualitative data were generated regarding Trypanosoma cruzi reservoirs and triatomine hosts. Blood meal analysis and infection of insects, dogs and rodents were determined. Based on these data, multimodel inference was used to identify risk factors for domestic infestation with the greatest relative importance (>0.75).Principal FindingsBlood meal analysis showed that 64% of 36 bugs fed on chickens, 50% on humans, 17% on dogs; 24% of 34 bugs fed on Rattus rattus and 21% on Mus musculus. Seroprevalence among 80 dogs was 37%. Eight (17%) of 46 M. musculus and three (43%) of seven R. rattus from households with infected triatomines were infected with T. cruzi Distinct Typing Unit I. Results from interviews and participatory meetings indicated that vector control personnel and some householders perceived chickens roosting and laying eggs in the house as bug infestation risk factors. House construction practices were seen as a risk factor for bug and rodent infestation, with rodents being perceived as a pest by study participants. Multimodel inference showed that house infestation risk factors of high relative importance are dog density, mouse presence, interior wall plaster condition, dirt floor, tile roofing and coffee tree presence.Conclusions/SignificancePersistent house infestation is closely related to eco-bio-social factors that maintain productive T. dimidiata habitats associated with dogs, chickens and rodents. Triatomine, dog and rodent infections indicate active T. cruzi transmission. Integrated vector control methods should include actions that consider the role of peridomestic animals in transmission and community memberś level of knowledge, attitudes and practices associated with the disease and transmission process.

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Section: Introductionmentioning

confidence: 99%

Ecological, Social and Biological Risk Factors for Continued Trypanosoma cruzi Transmission by Triatoma dimidiata in Guatemala

et al. 2014

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“…This was in part due to the low cost of procurement if purchased through the central government, as central level negotiates prices based on the previous year's budget year, but when a department runs out it must be purchased directly from private providers, usually at a higher price. Another study estimated for the costs of an indoor residual spraying (IRS) programme that included initial spraying followed by community-based surveillance and then with selective respraying in 317 villages in Guatemala (Hashimoto et al, 2012). The average number of units sprayed and surveyed multiplied by the unit costs of each determined the total cost; the spraying cost per house included insecticide, labour and transport, while surveillance was estimated at 80% of spray costs, and entomological survey costs were estimated.…”

Section: Chagas Diseasementioning

confidence: 99%

Economic and Financial Evaluation of Neglected Tropical Diseases

Lee

Bartsch

Gorham

2015

Advances in Parasitology

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“…(4) . Overall the organization has tested more than 114,000 people, diagnosed 11,000 and effectively treated more than 9,000, making this group of patients one of the largest in the world.…”

Section: Introductionmentioning

confidence: 99%

“…A fi nal certifi cation of Interruption of transmission of T. cruzi by R. prolixus was issued in 2005. Actions included the implementation of a community vigilance system, diagnosis, and treatment (4) .…”

Section: Introductionmentioning

confidence: 99%

High seroconversion rates in Trypanosoma cruzi chronic infection treated with benznidazole in people under 16 years in Guatemala

Brum-Soares¹,

Cubides²,

Burgos³

et al. 2016

Rev. Soc. Bras. Med. Trop.

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Introduction: Geographical, epidemiological, and environmental differences associated with therapeutic response to Chagas etiological treatment have been previously discussed. This study describes high seroconversion rates 72 months after benznidazole treatment in patients under 16 years from a project implemented by Doctors without Borders in Guatemala. Methods: An enzyme-linked immunosorbent assay was used to detect Trypanosoma cruzi IgG antibodies in capillary blood samples from patients 72 months after treatment. Fisher's exact test was used to establish association between characteristics, such as sex, age, and origin of patients, and fi nal seroconversion. Kappa index determined concordance between laboratory tests. The level of signifi cance was set to 5%. Results: Ninety-eight patients, aged 6 months to 16 years, were available for follow-up. Sex and origin were not associated with seroconversion. Individuals older than 13 were more prone to maintain a positive result 72 months after treatment, although results were not highly signifi cant. Laboratory tests presented elevated Kappa concordance (95% CI) = 0.8290 (0.4955-1), as well as high (97%) seroconversion rates. Conclusions: The high seroconversion rate found in this study emphasizes the importance of access to diagnosis, treatment, and follow-up of individuals affected by Chagas disease. Moreover, it contradicts the idea that it is not possible to achieve a cure with the currently available drugs. This study strongly supports expanding programs for patients infected with T. cruzi in endemic and non-endemic countries.

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Vector control intervention towards interruption of transmission of Chagas disease by Rhodnius prolixus, main vector in Guatemala

Cited by 21 publications

References 13 publications

Ecological, Social and Biological Risk Factors for Continued Trypanosoma cruzi Transmission by Triatoma dimidiata in Guatemala

Ecological, Social and Biological Risk Factors for Continued Trypanosoma cruzi Transmission by Triatoma dimidiata in Guatemala

Economic and Financial Evaluation of Neglected Tropical Diseases

High seroconversion rates in Trypanosoma cruzi chronic infection treated with benznidazole in people under 16 years in Guatemala

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