Vector control using LLIN/ITN: reduction of malaria morbidity in Bangladesh

Kabir, Mohammad M; Naher, Shamsun; Islam, Akramul; Karim, Abdul; Rasid, Mohammad Harun-Or; Laskar, Shahidul Islam

doi:10.1186/1475-2875-13-s1-p47

Cited by 8 publications

(9 citation statements)

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“…4).The current study showed significant correlation between distributed LLINs and malaria autochthonous foci. Nowadays, ITNs and LLINs are considered the most important interventions for prevention of malaria morbidity (Kabir et al 2014). This led to 63 % of spending on total malaria control commodities (artemisinin-based combination therapy, ITNs, insecticides and spraying equipment for IRS, and rapid diagnostic tests) being allocated to ITNs by WHO in 2014.…”

Section: Discussionmentioning

confidence: 99%

Some probable factors affecting the malaria situation before and at the beginning of a pre-elimination program in southeastern Iran

et al. 2016

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The area southeast of Iran still copes with malaria as an unstable infectious disease and includes the most autochthonous malaria reports in the country. This comprehensive study was carried out for the evaluation of environmental factors, welfare indicators and health facilities on the malaria situation before and at the beginning of a pre-elimination programme in this area. The probable factors affecting the malaria situation, including the water-pipe network, electricity, rainfall, long-lasting integrated nets (LLINs), indoor residual spraying and malaria diagnosis-treatment centres were analysed using SPSS software. The Pearson correlation test showed no significant correlation between some factors such as piped water networks, annual precipitation, number of sprayed villages and autochthonous cases as well as autochthonous foci. But a significant correlation between electricity coverage, number of diagnoses of malaria-treatment centres and autochthonous cases\foci was observed. Also, the number of distributed LLINs didn't have any correlation with the number of total malaria cases, but a significant correlation between LLINs and autochthonous foci was seen. Detailed studies on the correlation of various variables, such as piped water, spraying coverage and number of malaria diagnosis centres, with the malaria situation is limited in Asia and other parts of the world. This study and others like it can help malaria managers and directors in the more accurate allocation of financial resources.

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Section: Discussionmentioning

confidence: 99%

Some probable factors affecting the malaria situation before and at the beginning of a pre-elimination program in southeastern Iran

et al. 2016

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“…However, insecticide-impregnated mosquito nets are less used in Cape Verde, where a recent study shows that only 19% of the population use them, but if offered them, 91% would use it [4]. There is the potential to reduce the rate of infection, morbidity and mortality, through the very cost-effective mosquito net malaria prevention strategy [67].…”

Section: Drug Resistance Associated Molecular Markersmentioning

confidence: 99%

Drug resistance profile and clonality of Plasmodium falciparum parasites in Cape Verde: the 2017 malaria outbreak

Leal

Ward

Campino

et al. 2021

Malar J

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Background Cape Verde is an archipelago located off the West African coast and is in a pre-elimination phase of malaria control. Since 2010, fewer than 20 Plasmodium falciparum malaria cases have been reported annually, except in 2017, when an outbreak in Praia before the rainy season led to 423 autochthonous cases. It is important to understand the genetic diversity of circulating P. falciparum to inform on drug resistance, potential transmission networks and sources of infection, including parasite importation. Methods Enrolled subjects involved malaria patients admitted to Dr Agostinho Neto Hospital at Praia city, Santiago island, Cape Verde, between July and October 2017. Neighbours and family members of enrolled cases were assessed for the presence of anti-P. falciparum antibodies. Sanger sequencing and real-time PCR was used to identify SNPs in genes associated with drug resistance (e.g., pfdhfr, pfdhps, pfmdr1, pfk13, pfcrt), and whole genome sequencing data were generated to investigate the population structure of P. falciparum parasites. Results The study analysed 190 parasite samples, 187 indigenous and 3 from imported infections. Malaria cases were distributed throughout Praia city. There were no cases of severe malaria and all patients had an adequate clinical and parasitological response after treatment. Anti-P. falciparum antibodies were not detected in the 137 neighbours and family members tested. No mutations were detected in pfdhps. The triple mutation S108N/N51I/C59R in pfdhfr and the chloroquine-resistant CVIET haplotype in the pfcrt gene were detected in almost all samples. Variations in pfk13 were identified in only one sample (R645T, E668K). The haplotype NFD for pfmdr1 was detected in the majority of samples (89.7%). Conclusions Polymorphisms in pfk13 associated with artemisinin-based combination therapy (ACT) tolerance in Southeast Asia were not detected, but the majority of the tested samples carried the pfmdr1 haplotype NFD and anti-malarial-associated mutations in the the pfcrt and pfdhfr genes. The first whole genome sequencing (WGS) was performed for Cape Verdean parasites that showed that the samples cluster together, have a very high level of similarity and are close to other parasites populations from West Africa.

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“…However, insecticide-impregnated mosquito nets are less used in Cape Verde, where a recent study shows that only 19% of the population use them, but if offered them, 91% would use it (DePina, 2019b). Therefore, there is the potential to reduce the rate of infection, morbidity and mortality, through the very cost-effective mosquito net malaria prevention strategy (Kabir et al 2014).…”

Section: Characterization Of Malaria Casesmentioning

confidence: 99%

Drug resistance profile and clonality of Plasmodium falciparum parasites in Cape Verde: The 2017 malaria outbreak

Leal

Ward

Campino

et al. 2021

Preprint

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Background Cape Verde is an archipelago located off the West African coast, and is in a pre-elimination phase of malaria control. Since 2010, less than 20 Plasmodium falciparum malaria cases have been reported annually, except in 2017, when an outbreak in Praia before the rainy season led to 423 autochthonous cases. It is important to understand the genetic diversity of circulating P. falciparum to inform on drug resistance, potential transmission networks, and sources of infection, including parasite importation.Methods Enrolled subjects involved malaria patients admitted to Dr. Agostinho Neto Hospital at Praia city, Santiago island, Cape Verde, between July and October 2017. Neighbours and family members of enrolled cases were assessed for the presence of anti-P. falciparum antibodies. Sanger sequencing and real time PCR was used to identify SNPs in genes associated with drug resistance (e.g. pfdhfr, pfdhps, pfmdr1, pfk13, pfcrt), and whole genome sequencing data was generated to investigate the population structure of P. falciparum parasites.Results We analysed 190 parasite samples, 187 indigenous and three from imported infections. Malaria cases were distributed throughout Praia city. There were no cases of severe malaria, and all patients had an adequate clinical and parasitological response after treatment. Anti-P. falciparum antibodies were not detected in the 137 neighbours and family members tested. No mutations were detected in pfdhps. The triple mutation S108N/N51I/C59R in pfdhfr and the chloroquine resistant CVIET haplotype in the pfcrt gene were detected in almost all samples. Variations in pfk13 were identified in only one sample (R645T, E668K). The haplotype NFD for pfmdr1 was detected in the majority of samples (89.7%).Conclusions Polymorphisms in pfk13 associated with ACTs tolerance in Southeast Asia were not detected, but the majority of the tested samples carried the pfmdr1 haplotype NFD and antimalarial associated mutations in the the pfcrt and pfdhfr genes. We performed the first WGS for Cape Verdean parasites that showed that the samples cluster together, have a very high level of similarity and are close to other parasites populations from West Africa.

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Vector control using LLIN/ITN: reduction of malaria morbidity in Bangladesh

Cited by 8 publications

References 0 publications

Some probable factors affecting the malaria situation before and at the beginning of a pre-elimination program in southeastern Iran

Some probable factors affecting the malaria situation before and at the beginning of a pre-elimination program in southeastern Iran

Drug resistance profile and clonality of Plasmodium falciparum parasites in Cape Verde: the 2017 malaria outbreak

Drug resistance profile and clonality of Plasmodium falciparum parasites in Cape Verde: The 2017 malaria outbreak

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