2024
DOI: 10.1002/advs.202406545
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Vector‐Free Deep Tissue Targeting of DNA/RNA Therapeutics via Single Capacitive Discharge Conductivity‐Clamped Gene Electrotransfer

Jeremy L. Pinyon,
Georg von Jonquieres,
Stephen L. Mow
et al.

Abstract: Viral vector and lipid nanoparticle based gene delivery have limitations around spatiotemporal control, transgene packaging size, and vector immune reactivity, compromising translation of nucleic acid (NA) therapeutics. In the emerging field of DNA and particularly RNA‐based gene therapies, vector‐free delivery platforms are identified as a key unmet need. Here, this work addresses these challenges through gene electrotransfer (GET) of “naked” polyanionic DNA/mRNA using a single needle form‐factor which suppor… Show more

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