Vegetable oil-based polyurethanes as antimicrobial wound dressings: in vitro and in vivo evaluation

Abstract

Preparation of efficient polyurethane-type wound dressings with tunable physicomechanical properties and widespread antimicrobial activity is considered in this work. A new type of soybean oil-based polyol with built-in urethane and quaternary ammonium groups is synthesized through a nonisocyanate route using carbonated soybean oil as an environmentally friendly, renewable resource-based raw material. Different formulations from this polyol and castor oil are prepared and converted to the polyurethane wound dressings via a reaction with isophorone diisocyanate. The dressing sample, with good cytocompatibility and efficient antimicrobial activity against various microbial strains, having tensile strength of 5 and 17 MPa at hydrated and dry state, elongation at the break of up to 400%, equilibrium water absorption and a water vapor transmission rate of 50% and 390 g m−2 day−1, is used for in vivo assay on a rat. Evaluation of the optimized dressing for a full-thickness non-sterilized wound has shown excellent progress of wound healing, since the tensile strength of regenerated skin reaches about 80% of normal healthy skin on day 21 after wounding. This has been significantly superior to the tensile strength of the regenerated skin of rats covered with non-antibacterial (∼50%) and cotton gauze (∼40%) dressings as blank and control groups.

The Prospering of Macromolecular Materials Based on Plant Oils within the Blooming Field of Polymers from Renewable Resources

“…ionic and non-ionic polyurethane dispersions prepared in aqueous media. The materials are therefore evolving to more complex systems with specific applications, which is notably the case of the synthesis of vegetable oil-based polyurethanes for tissue engineering [29]. In this study, the thermosets exhibited good cytocompatibility and efficient antimicrobial activity against various microbial strains, and were considered suitable for wound dressing applications.…”

Biobased polyurethanes for biomedical applications

“…The membranes containing aniline tetramer moieties demonstrated the best wound healing after 20 days with higher (100%) wound closure compared to membranes without aniline tetramer. In an effort to develop more environmentally-friendly processes, another partially NIPU antibacterial membrane was recently developed from epoxidized soybean oil [ 214 ]. The epoxidized fatty acid was first modified into a cyclocarbonate soybean oil.…”

The Prospering of Macromolecular Materials Based on Plant Oils within the Blooming Field of Polymers from Renewable Resources

“…A thermo-reversible polyurethane network based on vegetable oils was prepared by reacting a furan oligomer derived from oleic acid, a linear rapeseed oil-based polyurethane, and a bismaleimide via the Diels–Alder reaction [ 70 ]. More complex systems with specific applications have also been considered, such as vegetable oil-based polyurethanes for tissue engineering [ 71 ]. In this case, thermosets with good cytocompatibility and efficient antimicrobial activity against various microbial strains may be prepared and considered for wound dressing applications.…”