Vegetable waste and by-products to feed a healthy gut microbiota: Current evidence, machine learning and computational tools to design novel microbiome-targeted foods

Sabater, Carlos; Calvete-Torre, Inés; Villamiel, Mar; Moreno, F. Javier; Margollés, Abelardo; Ruíz, Lorena

doi:10.1016/j.tifs.2021.10.002

Cited by 30 publications

(26 citation statements)

References 112 publications

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“…Arabinoxylan degrading enzymes were annotated in several MAGs of a wide range of genera present in both IBD and healthy metagenomes including Anaerostipes, Bacteroides, Bifidobacterium, Blautia, Butyrivibrio, Faecalibacterium, unidentified members of Lachnospiraceae, Prevotella, Paraprevotella and Ruminococcus (Figures 3 and 4, Supplementary material Tables S3 and S4). The potential of several of these genera to metabolise emerging prebiotics was reported in a previous study [14]. With regard to CD samples, xylanase domains were identified in all MAGs of Butyrivibrio and B. viscericola DSM 18177, as well as in most MAGs of other gut microbes such as P. xylaniphila YIT 11841 (Figure 3, Supplementary material Table S3).…”

Section: Study Of Mags Glycosidases Acting On Arabinoxylan and Pectinsupporting

confidence: 65%

“…Interestingly, several microbial clades (total number of different taxa n = 41) were also found in the microbiota of both patients with CD and healthy individuals (Tables 1 and 2). In this regard, these common taxa include health-promoting genera such as Faecalibacterium, Akkermansia, Blautia and Paraprevotella [14,22]. were recovered from the microbiota of patients with Crohn's disease and healthy individuals.…”

Section: Mags Recoverymentioning

confidence: 99%

“…Specifically, probiotic microorganisms belonging to Bifidobacterium and Lactobacillus genera may be beneficial for IBD remission. It should be considered that vegetable poly-and oligosaccharides comprise different families such as arabinoxylan and pectin-derived compounds that have been proposed as emerging prebiotics with enhanced bioactivity [14]. These prebiotic mixtures could be tailored to target specific diseases such as IBD [15,16].…”

Section: Introductionmentioning

confidence: 99%

“…Arabinoxylan consist of a linear backbone of 1500 to 15,000 β(1-4) D-xylopyranoside units, which can occur substituted with α-L-arabinofuranoside residues positioned on C-(O)-2 or C-(O)-3 [14,20]. In addition, xylose monomers may be substituted with glucuronic acid and its 4-O-methyl derivative.…”

Section: Introductionmentioning

confidence: 99%

“…On the other hand, pectin is mainly composed of linear chains of α-1,4-D-galacturonic acid (GalA) called homogalacturonan. Moreover, ramified domains of pectin comprise alternate sequences of GalA and α-(1, 2) linked α-L-rhamnosyl residues, which may be substituted at O-4 with linear or branched oligosaccharides [14,21]. Therefore, microbial enzymes acting on these polysaccharide structures involved the following activities: arabinofuranosidases, xylosidases, xylanases, xylan glucuronidases and oxidases, acetyl xylan esterases and pectin esterases, polygalacturonases, rhamnosidases, and polygalacturonate and rhamnogalacturonan lyases.…”

Section: Introductionmentioning

confidence: 99%

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Arabinoxylan and Pectin Metabolism in Crohn’s Disease Microbiota: An In Silico Study

Sabater

Calvete-Torre

Ruíz

et al. 2022

IJMS

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Inflammatory bowel disease is a chronic disorder including ulcerative colitis and Crohn’s disease (CD). Gut dysbiosis is often associated with CD, and metagenomics allows a better understanding of the microbial communities involved. The objective of this study was to reconstruct in silico carbohydrate metabolic capabilities from metagenome-assembled genomes (MAGs) obtained from healthy and CD individuals. This computational method was developed as a mean to aid rationally designed prebiotic interventions to rebalance CD dysbiosis, with a focus on metabolism of emergent prebiotics derived from arabinoxylan and pectin. Up to 1196 and 1577 MAGs were recovered from CD and healthy people, respectively. MAGs of Akkermansia muciniphila, Barnesiella viscericola DSM 18177 and Paraprevotella xylaniphila YIT 11841 showed a wide range of unique and specific enzymes acting on arabinoxylan and pectin. These glycosidases were also found in MAGs recovered from CD patients. Interestingly, these arabinoxylan and pectin degraders are predicted to exhibit metabolic interactions with other gut microbes reduced in CD. Thus, administration of arabinoxylan and pectin may ameliorate dysbiosis in CD by promoting species with key metabolic functions, capable of cross-feeding other beneficial species. These computational methods may be of special interest for the rational design of prebiotic ingredients targeting at CD.

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Section: Study Of Mags Glycosidases Acting On Arabinoxylan and Pectinsupporting

confidence: 65%

Section: Mags Recoverymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Arabinoxylan and Pectin Metabolism in Crohn’s Disease Microbiota: An In Silico Study

Sabater

Calvete-Torre

Ruíz

et al. 2022

IJMS

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Synergistic role of prebiotics and probiotics in gut microbiome health: Mechanisms and clinical applications

Kumari,

Bag,

Das

et al. 2024

Food Bioengineering

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Prebiotic and probiotic usage has exploded, with most formulations promoting gastrointestinal and immunological benefits. Prebiotics modulate the gut microbiota, as a result, short‐chain fatty acids are released into the bloodstream. Prebiotics have immunomodulatory properties that reduce inflammation while enhancing immune responses and boosting gut health. The potential of probiotics has shown steady expansion in the digestive system, metabolic balance, and vaginal health. Probiotics offer therapeutic and preventative strategies for a range of human diseases. The in vitro studies suggested the delivery matrix might influence their effects through physicochemical interactions with molecular and cellular structures as well as modifications in cellular expression. Dietary fibers and polyphenols both contribute significantly to human health protection and can ferment in the gut microbiota to create butyrate. This comprehensive review aims to highlight the probiotics and prebiotics, and provide evidence to support their use in preventive and therapeutic medicine. It is anticipated that it will help the clinical and preclinical research to look into the effects of inclusion and processing on their activity in different food delivery formulations. There are potential opportunities needed to enhance immunological and digestive health by comprehending and using the interaction between the gut microbiota and the immune system in our diet.

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Evaluation of Concrete Characteristics Using Smart Machine Learning Techniques—A Review

Kapoor,

Popli,

Sharma

et al. 2024

Lecture Notes in Civil Engineering

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Vegetable waste and by-products to feed a healthy gut microbiota: Current evidence, machine learning and computational tools to design novel microbiome-targeted foods

Cited by 30 publications

References 112 publications

Arabinoxylan and Pectin Metabolism in Crohn’s Disease Microbiota: An In Silico Study

Arabinoxylan and Pectin Metabolism in Crohn’s Disease Microbiota: An In Silico Study

Synergistic role of prebiotics and probiotics in gut microbiome health: Mechanisms and clinical applications

Evaluation of Concrete Characteristics Using Smart Machine Learning Techniques—A Review

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