Vegetating Darier Disease Treated With Botulinum Toxin

Ossorio-García, Lidia; Collantes‐Rodríguez, Cristina; Villegas‐Romero, Isabel; Linares‐Barrios, Mario

doi:10.1001/jamadermatol.2017.4299

Cited by 11 publications

(6 citation statements)

References 4 publications

(7 reference statements)

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“…47 However, only case reports have been published on this treatment. 43,47,48 Injections of botulinum toxin might be a good treatment option for persistent and refractory Darier disease, which needs further evaluation and validation.…”

Section: Discussionmentioning

confidence: 99%

Botulinum toxin in treating Hailey‐Hailey disease: A systematic review

Zhang

Tang

Wang

et al. 2021

J of Cosmetic Dermatology

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Hailey-Hailey disease, also called benign familial chronic pemphigus, is a rare autosomal dominant disorder characterized by recurrent painful blistering, erosions, maceration in the intertriginous regions. 1,2 Hailey-Hailey disease is caused by mutations in the ATP2C1 gene located on chromosome 3q21-q24, whose function is to transport Ca 2+ /Mn 2+ into the Golgi apparatus and maintain normal intracellular concentrations of Ca 2+ /Mn 2+3 . The appearance of "dilapidated brick wall" was a characteristic histopathologic change of Hailey-Hailey disease. 4 Severe impairment of quality of life was observed in Hailey-Hailey disease in the aspects of symptoms, emotions, and social functioning. 5 Nowadays, treatment options for Hailey-Hailey disease include corticosteroids, antibiotics, botulinum toxin, CO 2 ablation laser, and dermabrasion. 6 CO 2 laser therapy as a long-term treatment option for Hailey-Hailey disease has been systematically reviewed, offering an effective and safe treatment option with minimal side effects. 7 Botulinum toxin has also been widely used in cosmetic dermatology, noncosmetic dermatology, and nondermatological indications. [8][9][10][11][12][13] As early as 2000, it was applied in a patient with Hailey-Hailey disease and provided a sustained

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Section: Discussionmentioning

confidence: 99%

Botulinum toxin in treating Hailey‐Hailey disease: A systematic review

Zhang

Tang

Wang

et al. 2021

J of Cosmetic Dermatology

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“…Surgical interventions can be an option for the persistent localized type of Darier disease, which is resistant to conventional treatment. These interventions include surgical excision, electrosurgery, dermabrasion, laser ablation, photodynamic or electron beam therapy, and injection of botulinum toxin particularly in a patient with excessive sweating [ 26 , 28 ]. In 2015, Krakowski et al [ 29 ] successfully treated a teenage boy with segmental Darier disease using ablative fractional laser resurfacing.…”

Section: Discussionmentioning

confidence: 99%

Type 1 Segmental Darier Disease: Case Report and Discussion of the Treatment Options

2020

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Darier disease is a rare type of autosomal dominant genodermatosis, and it is caused by a mutation in the gene coding for the endoplasmic reticulum membrane calcium pump Ca2+-ATPase type 2, leading to compromised intercellular adhesion. Moreover, this condition is characterized by multiple keratotic greasy papules with a seborrheic distribution and is worsened by heat and sun exposure, sweating, and friction. Occasionally, it may be associated with nail abnormalities and may involve the mucosa. Unilateral segmental Darier disease is a rare variant characterized by unilateral eruption of erythematic keratotic papules not associated with other conditions. Herein, we report a case of type 1 segmental Darier disease. Furthermore, the main characteristics and treatment options are discussed.

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“…Our results are di cult to compare with those of published small-scale retrospective case series or some clinical cases. In DD, BtxA was used in only three patients in whom a reduction in skin lesions in the treated areas was reported without any objective quanti cation (49)(50)(51). In HHD, BtxA proved effective in 27 patients (small-scale retrospective case series including no more than eight patients (43) or clinical cases (34)(35)(36)(37)(38)(39)(40)(41)(42)).…”

Section: Discussionmentioning

confidence: 99%

Botulinum Toxin Injections as an Effective Treatment for Patients with Hailey-Hailey or Darier Disease: An open-label 6-month pilot interventional study

Dreyfus

Maza

Rodriguez

et al. 2020

Preprint

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Background: Patients with Hailey-Hailey and Darier diseases present with disabling inflammatory lesions located in large skin folds, which are often exacerbated or induced by sweating. Quality of life is highly impaired because of pain and recurrent skin infections. An improvement in skin lesions after botulinum toxin A injections has previously been reported in some patients but no prospective interventional studies are available. The aim of this open-label, 6-month, interventional pilot study (NCT02782702) was to evaluate the effectiveness and safety of botulinum toxin A injections. Thirty patients with moderate to very severe skin lesions located in folds were enrolled in the study. Results: Thirty patients (26 Hailey-Hailey / 4 Darier) were included. Botulinum toxin A proved effective within the first month in two-thirds of patients, taking all study parameters (itchiness, cutaneous pain, sweating and odour, infections, psychosocial impairment and quality of life) into account and persisted during the 6-month follow-up period. No patient was classed as a BtxA non-responder, but 11 (37%) patients, who were the most severe ones, experienced a relapse during the study. No serious side effects were reported. Mild transient clear fluid discharge at the site of the injections was reported for 27% of patients. Conclusions: Botulinic toxin is an effective and safe treatment for Hailey-Hailey and Darier diseases. Further studies should evaluate the benefit of increased doses or combined treatments for the most severe patients.Timing of approvals:- 25, February 2015: approval by the institutional ethics committee- 2, June 2015: registration under the European Eudract identifier 2015-000379-29 (https://eudract.ema.europa.eu/index.html)- 31, July 2015: approval by the French national health authority, ANSM - 31, August 2015: implementation agreement signed by the sponsor. - 25, May 2016: registration under the ClinicalTrials.gov identifier NCT02782702 (https://clinicaltrials.gov/ct2/show/NCT02782702?cond=NCT02782702&draw=2&rank=1).

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Vegetating Darier Disease Treated With Botulinum Toxin

Cited by 11 publications

References 4 publications

Botulinum toxin in treating Hailey‐Hailey disease: A systematic review

Botulinum toxin in treating Hailey‐Hailey disease: A systematic review

Type 1 Segmental Darier Disease: Case Report and Discussion of the Treatment Options

Botulinum Toxin Injections as an Effective Treatment for Patients with Hailey-Hailey or Darier Disease: An open-label 6-month pilot interventional study

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