“…The acute form is characterized by fever, depression, reluctance to move due to thoracic discomfort and/or lameness, and a rapid development of signs of heart insufficiency, with edema and increased jugular filling. The subacute or chronic form commonly appears with fever, BW loss, shifting lameness, poor performance, lethargy/depression, heart murmur, or a combination of these signs for weeks or even months [9,22]. There are four predisposing factors: endocardial damage, formation of a platelet-fibrin thrombus on the injured endothelium, bacteremia, and high agglutination antibody titers toward the infective organism [9].…”