Vegetative innervation of the esophagus

Pedrosa, Juan Ángel; Hernández, Carlos José; Rodrigo, José; Vidal, María Antonia

doi:10.1159/000144633

Cited by 8 publications

(1 citation statement)

References 4 publications

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“…Although these studies have suggested a role of mucosal receptors in gastric emptying, by detecting food particle size, and in the regulation of the vomiting vagal reflex (Becker and Kelly, 1983;Andrews and Wood, 1988;Kentish et al, 2015), none have directly shown the physiological role of mucosal afferents in vivo. Furthermore, mucosal afferents possess a diversity of morphological substructures and the ability to detect different types of tactile mechanical stimuli (Rodrigo et al, 1970(Rodrigo et al, , 1975aPedrosa et al, 1976;Wank and Neuhuber, 2001), similar to the cutaneous touch receptor characteristics (Abraira and Ginty, 2013). While this suggests that true mucosal mechanoreceptors may act as touch receptors for the viscera, the presence of polymodal (i.e., detect chemical and thermal stimuli) vagal afferent populations may contradict this premise (Iggo, 1955;Clarke and Davison, 1978;Jänig, 1996;Lennerz et al, 2007).…”

Section: Mucosal Receptorsmentioning

confidence: 99%

Dissecting the Role of Subtypes of Gastrointestinal Vagal Afferents

2020

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Gastrointestinal (GI) vagal afferents convey sensory signals from the GI tract to the brain. Numerous subtypes of GI vagal afferent have been identified but their individual roles in gut function and feeding regulation are unclear. In the past decade, technical approaches to selectively target vagal afferent subtypes and to assess their function has significantly progressed. This review examines the classification of GI vagal afferent subtypes and discusses the current available techniques to study vagal afferents. Investigating the distribution of GI vagal afferent subtypes and understanding how to access and modulate individual populations are essential to dissect their fundamental roles in the gut-brain axis.

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Section: Mucosal Receptorsmentioning

confidence: 99%

Dissecting the Role of Subtypes of Gastrointestinal Vagal Afferents

2020

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Chest Pain of Esophageal Origin and Reflux Hypersensitivity

Błoński

Richter

2017

Gastrointestinal Motility Disorders

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Intraganglionic laminar endings in the rat esophagus contain purinergic P2X 2 and P2X 3 receptor immunoreactivity

Wang

Neuhuber

2003

Anatomy and Embryology

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Intraganglionic laminar endings (IGLEs) represent the most prominent vagal afferent terminal structures throughout the gastrointestinal tract. They are most prominent in the esophagus and stomach, but can be found down to the distal colon. Their role as mechanosensors as proposed on anatomical grounds was recently substantiated in elegant functional experiments. There is evidence that vagal mechanosensors in the esophagus and stomach respond to ATP. Thus, the present study aimed at detecting purinergic receptors on IGLEs. IGLEs in the rat esophagus were identified by immunohistochemistry for calretinin and sections were co-incubated with antibodies directed against P2X2 or P2X3 receptors. Also, double label immunocytochemistry for purinergic receptors and calcitonin gene-related peptide as a marker for spinal afferents was performed. Terminal nerve fibers immunoreactive for P2X2 and P2X3, respectively, were observed between outer and inner layers of the tunica muscularis, covering myenteric ganglia totally or partly. Both P2X2 and P2X3 receptor immunoreactivities were highly co-localized with calretinin positive IGLEs as shown by confocal laser scanning microscopy. Numerous calcitonin gene-related peptide immunostained fibers were found to closely approach and intermingle with P2X immunopositive IGLEs. However, there was never co-staining for either of the purinergic receptors and calcitonin gene-related peptide within the same fibers. P2X3 but not P2X2 immunoreactivity was also observed within nerve fiber arborizations in the mucosa of the pharynx. In the nodose ganglion, 8.9 +/- 1.1% of P2X2 and 7.2 +/- 1.3% of P2X3 immunopositive neurons, respectively, co-stained for calretinin. On the other hand, 63.4 +/- 4.6% and 60.1 +/- 5.3% of calretinin positive cell bodies contained P2X2 and P2X3 receptor immunoreactivity, respectively. These results indicate that IGLEs are equipped with both P2X2 and P2X3 receptors. Thus, they may act as chemosensors or their mechanosensory properties may be modulated by ATP. It is also suggested that spinal afferents innervating the esophagus are equipped with neither P2X2 nor P2X3 purinergic receptors.

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Vegetative innervation of the esophagus

Cited by 8 publications

References 4 publications

Dissecting the Role of Subtypes of Gastrointestinal Vagal Afferents

Dissecting the Role of Subtypes of Gastrointestinal Vagal Afferents

Chest Pain of Esophageal Origin and Reflux Hypersensitivity

Intraganglionic laminar endings in the rat esophagus contain purinergic P2X 2 and P2X 3 receptor immunoreactivity

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