Vegetative innervation of the esophagus. III. Intraepithelial endings

Rodrigo, José; Hernández, Carlos José; Vidal, María Antonia; Pedrosa, Juan Ángel

doi:10.1159/000144444

Cited by 78 publications

(44 citation statements)

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“…It should be remembered that, although IGLEs are the most plentiful and most homogeneously dis tributed sensorial apparatus in the esopha gus, the plexuses of this organ are provided with a great variety and profuse distribution of sensorial structures [Sabussow, 1913;Temesréskâsi, 1956;Spassowa, 1959;Kadanoff, 1966;Rodrigo et al, 1970Rodrigo et al, , 1973Rodrigo et al, , 1975aRodrigo et al, , b, 1980Rodrigo et al, , 1981.…”

Section: Discussionmentioning

confidence: 99%

Sensory Vagal Nature and Anatomical Access Paths to Esophagus Laminar Nerve Endings in Myenteric Ganglia. Determination by Surgical Degeneration Methods

Rodrigo

Felipe

Robles-Chillida

et al. 1982

Cells Tissues Organs

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The dependence, access paths and functional significance of the intraganglionic laminar nerve endings (IGLEs) in the esophageal wall of the cat are demonstrated. To this end Wallerian degeneration was induced on the vagus nerve by a number of surgical operations performed at the nodose ganglion level. The results show IGLEs to be sensorial receptors dependent on neuronal bodies situated in the nodose ganglion. The nerve fibers on which they depend to reach the esophageal wall gain access via the vagus and the superior laryngeal nerve.

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Section: Discussionmentioning

confidence: 99%

Sensory Vagal Nature and Anatomical Access Paths to Esophagus Laminar Nerve Endings in Myenteric Ganglia. Determination by Surgical Degeneration Methods

Rodrigo

Felipe

Robles-Chillida

et al. 1982

Cells Tissues Organs

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“…Therapeutic agents that stimulate cholinergic mechanisms may exert benefits primarily through this mechanism [44]. Defective responses of salivary secretion to oesophageal acidification have been reported in patients with reflux oesophagitis.…”

Section: Defective Oesophageal Acid Clearancementioning

confidence: 99%

Gastro-Oesophageal Reflux Disease

Dent¹

1998

Digestion

107

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New approaches to the grading of reflux oesophagitis and the definition of reflux disease have been proposed which should improve the precision of descriptions of this common problem. Endoscopy and 24-hour pH monitoring studies, though of great value, have significant limitations for assessment of reflux disease. Only about one third of reflux disease patients have oesophageal mucosal erosion or ulceration. Analysis of symptoms is probably the most useful method for diagnosis. Further research is needed into the best strategies for maximising the potential of symptom analysis. In the pathogenesis of reflux disease, Helicobacter pylori infection is not a major factor but the interaction of H. pylori gastritis and eradication therapy are important areas of great current interest. Troublesome reflux disease arises primarily from abnormally frequent gastro-oesophageal reflux, though heightened oesophageal mucosal sensitivity and defective oesophageal clearance play a role in some patients. Transient lower oesophageal sphincter relaxation appears to be the most important mechanism of reflux. This distinctive, swallow-independent type of lower oesophageal sphincter relaxation has a complex triggering system, apparently located in the brain stem. Medical and surgical treatments of reflux disease are now well characterised and have improved very substantially over recent years. Drugs that inhibit the occurrence of transient lower oesophageal sphincter relaxation are an intriguing possible future therapy.

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“…In our opinion, this abrupt interruption of the nerve fibre is not sufficient justification of its sensory nature, since the interruption may be due to a section of their path, an abrupt change in direction or an unstained zone, all of which are possible situations in both efferent and afferent fibres. So far, the sensory fibres we have described in the oesophagus [Rodrigo et a!., 1970, 1975a: Pedrosa et a i, 1976 have mainly shown a more or less complex terminal portion because of the irregular disposition of the fibre and its collateral in this zone. Ter minal apparatuses in the alimentary canal have never taken the form of a simple interruption of the fibre or a varicosity, with the exception of intra-epithelial nerve endings in the eso phagus [Rodrigo et at., 1975b].…”

Section: Discussionmentioning

confidence: 89%

“…So far, the sensory fibres we have described in the oesophagus [Rodrigo et a!., 1970, 1975a: Pedrosa et a i, 1976 have mainly shown a more or less complex terminal portion because of the irregular disposition of the fibre and its collateral in this zone. Ter minal apparatuses in the alimentary canal have never taken the form of a simple interruption of the fibre or a varicosity, with the exception of intra-epithelial nerve endings in the eso phagus [Rodrigo et at., 1975b].…”

Section: Discussionmentioning

confidence: 89%