VEGF: a critical player in neurodegeneration

Storkebaum, Erik; Carmeliet, Peter

doi:10.1172/jci200420682

Cited by 73 publications

(78 citation statements)

References 49 publications

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“…Wachstumsfaktoren, die das angiogene Gefäßwachstum stimulieren, sind der "vascular endothelial growth factor" (VEGF), der "hepatocyte growth factor" (HGF) oder das Erythropoietin. Mehrere Studien zeigten eine erhöhte Expression angiogener Wachstumsfaktoren auch nach experimentell induziertem Schlaganfall [34,38].…”

Section: Gefäßwachstumunclassified

“…In experimentellen Studien konnte gezeigt werden, dass einige angiogene Faktoren nach experimentell induziertem Schlaganfall vermehrt exprimiert werden [34,38]. Auf der anderen Seite verstärken angiogene Wachstumsfaktoren wie der "vascular endothelial growth factor" (VEGF) durch die gesteigerte vaskuläre Permeabilität das postischämische Hirnödem und verringern somit den günstigen Effekt auf die zerebrale Perfusion [34,36,38] Der Ansatzpunkt der therapeutisch induzierten Arteriogenese liegt dagegen in der Verbesserung der arteriellen Blutzufuhr infolge des gesteigerten Wachstums der präformierten Kollateralgefäße. Nach dem Hagen-Poiseuille-Gesetz sinkt der Gefäß-bzw.…”

Section: Introductionunclassified

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Therapeutisch induzierte Arteriogenese im Gehirn

et al. 2006

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Stroke is the leading cause of disability and a major cause of death in Germany and the western world. Ischemic stroke involves different pathophysiologic mechanisms such as thromboembolic vascular occlusion, cerebral micro- or macroangiopathy, extracranial arterial stenosis, and cardiac embolism. Experimental and clinical studies have shown that arteriogenesis, the adaptive growth of pre-existing collateral arteries, can be therapeutically enhanced in peripheral circulation and the heart. We examined the consequences to time course and hemodynamics of brain arteriogenesis in a chronic hypoperfusion model following systemic administration of the hemopoietic growth factor called granulocyte macrophage colony stimulating factor (GM-CSF). Treatment with GM-CSF led to the growth of intracranial collateral arteries, which improved the cerebral hemodynamic reserve and significantly reduced energy failure when brains were additionally challenged by hypotension. Therapeutically induced arteriogenesis may be of considerable interest for preventing infarction in patients with uncompensated cerebrovascular disease.

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Section: Gefäßwachstumunclassified

Section: Introductionunclassified

Therapeutisch induzierte Arteriogenese im Gehirn

et al. 2006

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“…Besides, it could be part of some other processes such as neuroprotection. In this sense, reduced levels of VEGF have been implicated in several neurodegenerative disorders (Storkebaum and Carmeliet, 2004). Future studies will help us to assign a specific role for VEGF and NRP in brain maturation.…”

Section: Discussionmentioning

confidence: 93%

Quantification of Vascular Endothelial Growth Factor and Neuropilins mRNAs During Rat Brain Maturation by Real-Time PCR

Adris

Ojeda²,

Genero³

et al. 2005

Cell Mol Neurobiol

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1. Vascular endothelial growth factor (VEGF) has been related with several brain functions such as angiogenesis, neuroprotection, and neurogenesis. 2. We studied the mRNA expression of the two most important isoforms of VEGF (VEGF120 and VEGF164) as well as one type of VEGF receptors, neuropilins (NRP), during maturation in the rat brain using real-time PCR. 3. Today, real-time PCR is the method of choice for rapid and reliable quantification of mRNA transcription. 4. VEGF120 has little changes in its expression between P5 and P30. 5. However, VEGF164 increased its expression 2-folds at P15 in comparison to P5, remaining at this level in the adult brain (P30). 6. Both types of NRP, NRP-1 and NRP-2, which only bind VEGF164, increased their expression about 2-folds only at P30, at levels similar to those observed for VEGF164.

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“…In addition, researchers are exploring the role of VEGF as a trophic factor for neural cells in the retina, such as retinal progenitor cells and photoreceptors. Evidence also suggests that VEGF may have neuroprotective properties in the eye and other parts of the nervous system (Jin et al, 2000;Storkebaum and Carmeliet, 2004;Shima et al, 2004).…”

Section: Vegf and Human Physiologymentioning

confidence: 99%