VEGF and FGF signaling during head regeneration in hydra

Turwankar, Anuprita; Ghaskadbi, Surendra

doi:10.1016/j.gene.2019.144047

Cited by 20 publications

(13 citation statements)

References 35 publications

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“…Transcriptional misregulation and central carbon metabolism in cancer pathways were enriched in coral DEGs at 31 and 32°C, most of which were related to immune responses, apoptosis, oncogenesis and regulation of cell proliferation. Ten overexpressed genes were annotated as fibroblast growth factor receptor (FGFRs), which are involved in various biological processes, including cell proliferation, differentiation, survival, migration and apoptosis (Haugsten et al ., 2010), and they play a critical role in cnidarian development (Matus et al ., 2007; Turwankar and Ghaskadbi, 2019). Deregulation of FGFR signalling is implicated in several developmental syndromes and in many types of cancer (Haugsten et al ., 2010), and it is associated with growth anomalies in Platygyra carnosa (Zhang et al ., 2017).…”

Section: Discussionmentioning

confidence: 99%

Microbial community and transcriptional responses to increased temperatures in coral Pocillopora damicornis holobiont

Long

Zou

et al. 2020

Environmental Microbiology

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A few studies have holistically examined successive changes in coral holobionts in response to increased temperatures. Here, responses of the coral host Pocillopora damicornis, its Symbiodiniaceae symbionts, and associated bacteria to increased water temperatures were investigated. High temperatures induced bleaching, but no coral mortality was observed. Transcriptome analyses showed that P. damicornis responded more quickly to elevated temperatures than its algal symbionts. Numerous genes putatively associated with apoptosis, exocytosis, and autophagy were upregulated in P. damicornis, suggesting that Symbiodiniaceae can be eliminated or expelled through these mechanisms when P. damicornis experiences heat stress. Furthermore, apoptosis in P. damicornis is presumably induced through tumour necrosis factor and p53 signalling and caspase pathways. The relative abundances of several coral disease-associated bacteria increased at 32 C, which may affect immune responses in heat-stressed corals and potentially accelerates the loss of algal symbionts. Additionally, consistency of Symbiodiniaceae community structures under heat stress suggests nonselective loss of Symbiodiniaceae. We propose that heat stress elicits interrelated response mechanisms in all parts of the coral holobiont.

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Section: Discussionmentioning

confidence: 99%

Microbial community and transcriptional responses to increased temperatures in coral Pocillopora damicornis holobiont

Long

Zou

et al. 2020

Environmental Microbiology

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“…A good example of this is the fibroblast growth factor (FGF) signalling pathway, implicated in a wide range of biological processes such as cell migration, differentiation and proliferation, during development, wound healing and regeneration ( Thisse and Thisse, 2005 ; Dorey and Amaya, 2010 ). Regeneration in hydra, zebrafish, Xenopus and salamanders relies on the expression of FGF genes, and applying FGF receptor (FGFR) inhibitors results in regenerative defects ( Poss et al, 2000 ; Lee et al, 2005 ; Lin and Slack, 2008 ; Makanae et al, 2014 ; Shibata et al, 2016 ; Turwankar and Ghaskadbi, 2019 ). The FGF signalling pathway also plays important roles in development and regeneration of the vertebrate skeleton.…”

Section: Introductionmentioning

confidence: 99%

FGF signalling plays similar roles in development and regeneration of the skeleton in the brittle star Amphiura filiformis

et al. 2021

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Regeneration as an adult developmental process is in many aspects similar to embryonic development. Although many studies point out similarities and differences, no large-scale, direct and functional comparative analyses between development and regeneration of a specific cell type or structure in one animal exist. Here, we use the brittle star Amphiura filiformis to characterise the role of the FGF signalling pathway during skeletal development in embryos and arm regeneration. In both processes, we find ligands expressed in ectodermal cells that flank underlying skeletal mesenchymal cells, which express the receptors. Perturbation of FGF signalling showed inhibited skeleton formation in both embryogenesis and regeneration, without affecting other key developmental processes. Differential transcriptome analysis finds mostly differentiation genes rather than transcription factors to be downregulated in both contexts. Moreover, comparative gene analysis allowed us to discover brittle star-specific differentiation genes. In conclusion, our results show that the FGF pathway is crucial for skeletogenesis in the brittle star, as in other deuterostomes, and provide evidence for the re-deployment of a developmental gene regulatory module during regeneration.

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“…However, by contrast with Nematostella , FGF16 was expressed in all regeneration stages of T. coccinea . Moreover, in Hydra , FGF genes are expressed in interstitial cells (i‐cells; Krishnapati & Ghaskadbi, 2013), mediating their differentiation into neurons and nematocysts (Lange et al, 2014), and also during hypostome and tentacle regeneration (Turwankar & Ghaskadbi, 2019). While i‐cells have not been unequivocally identified in anthozoans, Richards and Rentzsch (2014) established that a comparable stem cell lineage is present; further studies are necessary to determine whether FGF signaling during early regeneration in Tubastraea plays similar roles as in Hydra .…”

Section: Discussionmentioning

confidence: 99%

“…Although sexual reproduction may limit the investment into somatic functions by increasing differentiation of stem cells into gametes, asexual offspring arise largely from stem cells (Sebestyén et al, 2018). Also, hydrozoans (e.g., Hydra) and sea anemones (e.g., Nematostella) can reactivate central developmental programs, such as the conserved Wnt, FGF, Notch, MAPK-CREB, and BMP/chordin signaling pathways (Chera et al, 2011;Dubuc et al, 2014;Mehta & Singh, 2019;Münder et al, 2013;Turwankar & Ghaskadbi, 2019). Amongst these, the Wnt and FGF signaling pathways in particular play key roles in axialpatterning, morphogenesis and cell movement, proliferation, and differentiation (Abnave & Ghigo, 2019;Chera et al, 2009;Dubuc et al, 2014;Lange et al, 2014;Lee & Miura, 2014;Maddaluno et al, 2017;Sun & Irvine, 2014;Vogg et al, 2019;Vriz et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

High regenerative capacity is a general feature within colonial dendrophylliid corals (Anthozoa, Scleractinia)

2021

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The regenerative capacity of cnidarians plays an essential role in the maintenance and restoration of coral reef ecosystems by allowing faster recovery from disturbances and more efficient small‐scale dispersal. However, in the case of invasive species, this property may contribute to their dispersal and success in nonnative habitats. Given that four Indo‐Pacific members of the coral genus Tubastraea have invaded the Atlantic, here we evaluated the ability of three of these species (Tubastraea coccinea, Tubastraea diaphana, and Tubastraea micranthus) to regenerate from fragments of undifferentiated coral tissue to fully functional polyps in response to differences in food supply and fragment size. For comparative purposes, another colonial dendrophylliid (Dendrophyllia sp.) was included in the analyses. All dendrophylliids displayed regenerative ability and high survival rates that were independent of whether or not food was supplied or fragment size. However, regeneration rates varied between species and were influenced by fragment size. Temporal expression of key genes of the regenerative process (Wnt and FGF) was profiled during whole‐body regeneration of T. coccinea, suggesting a remarkable regenerative ability of T. coccinea that points to its potential use as a laboratory model for the investigation of regeneration in colonial calcified anthozoans.

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VEGF and FGF signaling during head regeneration in hydra

Cited by 20 publications

References 35 publications

Microbial community and transcriptional responses to increased temperatures in coral Pocillopora damicornis holobiont

Microbial community and transcriptional responses to increased temperatures in coral Pocillopora damicornis holobiont

FGF signalling plays similar roles in development and regeneration of the skeleton in the brittle star Amphiura filiformis

High regenerative capacity is a general feature within colonial dendrophylliid corals (Anthozoa, Scleractinia)

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