VEGF and ki 67 expression in squamous cell carcinoma of the tongue: An immunohistochemical and computerized image analysis study

Faratzis, G.; Tsiambas, Evangelos; Rapidis, Alexander D.; Machaira, Aggeliki; Xiromeritis, Konstantinos; Patsouris, Efstratios

doi:10.1016/j.oraloncology.2008.08.002

Cited by 20 publications

(20 citation statements)

References 37 publications

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“…In current study, Ki-67 up-regulation is associated with down-regulation in XRCC2, leading to an excessive proliferation in breast tumors, which may result in aggressiveness of tumor. Similar results have earlier been observed when ki-67 was correlated with BER pathway genes in HNSCC [10], with VEGF in TSCC [35], with carbonic anhydrase 1X in TSCC [36] and with SOD2 in TSCC [37]. In addition to this, our study also demonstrated that Ki-67 showed an association with common histopathological parameters.…”

Section: Discussionsupporting

confidence: 91%

Association of reduced XRCC2 expression with lymph node metastasis in breast cancer tissues

et al. 2014

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The main purpose of this study was to evaluate the association between reduction in XRCC2 gene and involvement of lymph node metastasis in breast cancer. In first part of the study, meta-analysis of 14 published XRCC2 studies was performed to define the role of XRCC2 gene as diagnostic marker and in second part of the study XRCC2 gene expression was observed using real time PCR in study cohort of 100 females (50 breast cancer patients and 50 controls). A statistically significant down regulation of XRCC2 (p < 0.04) and up-regulation of ki-67 (p < 0.05) was observed in breast cancer tissues compared to non-cancerous healthy tissues. In order to explore gene-gene and gene-clinicopathological parameters relationship Spearmen correlation was performed. We observed a significantly negative correlation between XRCC2 and Ki-67 expression (r = -0.376**, p < 0.01). In case of gene-clinicopathological parameters relationship, we observed a significant correlation between XRCC2 expression and lymph node status (r = -0.521***, p < 0.002) and metastatic status (r = -0.303*, p < 0.04) of breast cancer patients. Our data suggests that deregulation of XRCC2 in breast cancer has the potential to predict lymph node metastasis and may serve as a therapeutic target for breast cancer patients at risk of metastasis.

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Section: Discussionsupporting

confidence: 91%

Association of reduced XRCC2 expression with lymph node metastasis in breast cancer tissues

et al. 2014

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“…proliferation) and tumor heterogeneity, is not necessarily conflicting. A previous study by Faratzis et al, 27 in which immunohistochemical VEGF and Ki-67 expression was investigated in a cohort of 87 patients with SCC of the tongue, did not find a statistical correlation between VEGF and Ki-67 expression.…”

Section: Discussionmentioning

confidence: 78%

Correlation of a priori DCE-MRI and 1H-MRS data with molecular markers in neck nodal metastases: Initial analysis

Jansen

Carlson

et al. 2012

Oral Oncology

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“…Staining was evaluated by computerized image analysis that offered accurate and fast means of estimation, depending on some objective parameters, such as optical density [16, 17]. Thus, this method was better than conventional eye microscopy in handling and evaluating a large number of immunohistochemical data [16,17]. …”

Section: Discussionmentioning

confidence: 99%

“…Quantitative evaluation of staining intensity levels of the corresponding markers was performed by a computerized semi automated image analysis system (Hardware: Mobile Intel Pentium Dual core/ Digital Still Camera SONY CyberShot DSC-P73 (1024X768), microscope Olympus CX-31, Software: Windows XP/Image Pro Plus version 5.1-Media Cybernetics 2000) (Fig. 1 ) [16]. A macro was implemented based on the control group (breast and lung cancerous epithelia) and protein expression of the lesions (cyst specimens).…”

Section: Materials and Methodologymentioning

confidence: 99%

Notch 1 Receptor, Delta 1 Ligand and HES 1 Transcription Factor are Expressed in the Lining Epithelium of Periapical Cysts (Preliminary Study)

Meliou

Kerezoudis²,

Tosios³

et al. 2010

TODENTJ

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Periapical cyst is a chronic inflammatory disorder of periradicular tissues. The precise pathological mechanisms involved in periapical cyst enlargement remain unclear. Notch signaling is an evolutionarily conserved pathway with a regulatory role in cell fate decisions during development and in carcinogenesis. To date, there are no published data available on the expression of Notch signaling components in periapical cysts or any other jaw cyst. In this immunohistochemical study we have examined the expression of the receptor Notch 1, the ligand Delta 1 and the transcription factor HES 1 in the epithelium of well defined periapical cysts. Immunostaining reaction of Notch 1, Delta 1 and HES 1 was observed in the cytoplasm and/or the cytoplasmic membrane and occasionally in the nucleus in the majority of epithelial cells of all periapical cysts. The present observations indicate that Notch pathway is active in the epithelium of periapical cysts. It can be speculated that activation of epithelial cells of periapical cysts is associated with activation of Notch pathway and imply involvement of this pathway in periapical cyst growth and expansion.

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VEGF and ki 67 expression in squamous cell carcinoma of the tongue: An immunohistochemical and computerized image analysis study

Cited by 20 publications

References 37 publications

Association of reduced XRCC2 expression with lymph node metastasis in breast cancer tissues

Association of reduced XRCC2 expression with lymph node metastasis in breast cancer tissues

Correlation of a priori DCE-MRI and 1H-MRS data with molecular markers in neck nodal metastases: Initial analysis

Notch 1 Receptor, Delta 1 Ligand and HES 1 Transcription Factor are Expressed in the Lining Epithelium of Periapical Cysts (Preliminary Study)

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