VEGF and sFLT-1 in serum of PIH patients and effects on the foetus

Tang, Yanhong; Ye, Wenfeng; Liu, Xia; Lv, Yan; Yao, Changfang; Jiang, Wei

doi:10.3892/etm.2019.7184

Cited by 17 publications

(17 citation statements)

References 30 publications

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“…After uterine and placental perfusion causes oxidative stress in vivo and hypoxia, sFlt‐1 prevents the binding of endothelin receptors to PlGF or VEGF on the cell surface, chelates free PlGF and VEGF and induces endothelial cell dysfunction. These processes lead to maternal hypertension and vasoconstriction 32 . Therefore, we speculate that the level of VEGF decreases when the level of sFlt‐1 increases and that sFlt‐1 affects the infiltration of trophoblast cells by inhibiting their synthesis, thus resulting in pre‐eclampsia.…”

Section: Discussionmentioning

confidence: 95%

Levels of serum Hoxb3 and sFlt‐1 in pre‐eclamptic patients and their effects on pregnancy outcomes

Zhou

Guo

Sun

et al. 2020

J of Obstet and Gynaecol

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Aim: We aimed to explore a new approach and theoretical basis for the diagnosis, treatment and prognosis of pre-eclampsia. Methods: In total, 103 pre-eclamptic patients (study group: SG) and 100 healthy pregnant women (control group: CG) were enrolled. Reverse transcription quantitative polymerase chain reaction (RT-qPCR) was used to detect the expression level of serum Hoxb3. Enzyme-linked immunosorbent assay was used to detect the content of serum sFlt-1. Pregnancy outcomes in the two groups were recorded, and the correlations of the levels of Hoxb3 and sFlt-1 with the pregnancy outcomes were analyzed. Results: The relative expression of serum Hoxb3 mRNA in the CG was significantly higher than that in the SG, whereas the content of serum sFlt-1 in the CG was significantly lower than that in the SG. Compared with the CG, the SG had a significantly lower number of spontaneous deliveries, higher number of cesarean deliveries and significantly higher number of uneventful perinatal births. The incidences of intrauterine growth restriction, intrauterine distress, premature infants and neonatal deaths in perinatal infants in the SG were significantly higher than those in the CG. According to the analysis of receiver operating characteristic curves, the areas under the curves of Hoxb3, sFlt-1 and their combined detection for diagnosing preeclampsia were 0.799, 0.856 and 0.930, respectively. The areas under the curves for predicting poor perinatal outcomes were 0.724, 0.828 and 0.871, respectively. Conclusion: In conclusion, Hoxb3 and sFlt-1 have certain reference significance for the risk evaluation of pre-eclampsia and the adverse pregnancy outcomes of pre-eclampsia women.

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Section: Discussionmentioning

confidence: 95%

Levels of serum Hoxb3 and sFlt‐1 in pre‐eclamptic patients and their effects on pregnancy outcomes

Zhou

Guo

Sun

et al. 2020

J of Obstet and Gynaecol

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“…Some TTTS cases may present with hypoxia or ischemia in the donor villi, which lead to the hypoxia/ischemia in donor villi due to the decreased fetal villi perfusion rather than the abnormality of placenta circulation 25 . The expression of VEGF-R1 has been reported to be inversely correlated with fetal weight at birth and Apgar score in patients with gestational hypertension 26 . Our results showed a significant decrease in VEGF-R1 and VEGF-R2 levels in twin pregnant women with TTTS after being treated with laser surgery suggesting a role of VEGF-R1 and VEGF-R2 in assessing the effectiveness of TTTS treatment.…”

Section: Discussionmentioning

confidence: 99%

Maternal vascular endothelial growth factor receptor and interleukin levels in pregnant women with twin-twin transfusion syndrome

Anh¹,

Thuong²,

Sim³

et al. 2021

Int. J. Med. Sci.

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Twin-twin transfusion syndrome (TTTS) is an unusual and serious condition that occurs in twin pregnancies when identical twins share a placenta but develop discordant amniotic fluid volumes. TTTS is associated with an increased risk of fetal death and birth defects if untreated. This study investigated the soluble levels of biomarkers including growth factors and interleukins in pregnant women with and without TTTS during pregnancy. We quantified plasma levels of VEGF-R1, VEGF-R2, IL-1β, IL-6 and IL-8 in twin pregnant women with (n=53) and without TTTS (n=72) and in women with single pregnancy (n=30) by ELISA and analyzed the association of maternal circulating biomarker levels with TTTS. Our results showed that maternal VEGF-R1 levels were significantly higher in twins compared to single pregnancy (P<0.05) and were decreased in the second trimester compared to the first trimester (P = 0.065, 0.019 and 0.072 for twins with and without TTTS and single pregnancy, respectively). VEGF-R2 levels had a trend to be lower in twins compared to single pregnancy. In addition, soluble VEGF-R1 and VEGF-R2 levels were significantly decreased while IL-6 levels were increased after surgical treatment with laser in twin pregnant women with TTTS (P = 0.016, 0.041 and 0.04, respectively). These results suggest that IL-6, VEGF-R1 and VEGF-R2 are involved in vascular regulation and stabilization in twin pregnancies and may contribute to the pathogenesis of TTTS and thus play a prognostic role in the surgical treatment of TTTS.

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“…[10] By Tang et al, on 105 PE subjects, a study was piloted, they found a sound increase in sFlt1 levels in PE and complicated PE pregnancies, especially in intrauterine fetal growth and development. [11] In a cohort study, in California on 97 pregnant women tested sFlt1 levels by comparing nulliparous and multiparous women, in first and second pregnancies and observed an increase in their sFlt1 levels during first pregnancies than second pregnancy and can be a predictor marker in primigravida. As it is a known factor that primigravida women were at risk for PE.…”

Section: Discussionmentioning

confidence: 99%

Association of sflt-1 as a maternal serum biomarker in preeclampsia: A case–control tertiary care hospital based study

Changalvala

Kiranmayee

Raghuveer

et al. 2021

IJMS

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Objectives: Preeclampsia (PE) is a multisystemic disorder portrayed by the new beginning of circulatory pressure more noteworthy than 140/90 mmHg and proteinuria with 0.3 g in a 24 h on dip stick emerging after 20 weeks of incubation. The hidden pathophysiology of PE includes endothelial brokenness and vasospasm beginning principally in the placenta. The unusual growth of blood vessels in placenta leads to poor perfusion. This relative hypoxic condition in placenta causes arrival of antiangiogenic factors into the maternal blood dissemination which prompts the modifications in maternal fundamental endothelial functions and causes hypertension. Soluble fms-like tyrosine kinase (sFlt) can form a heterodimer, binding with vascular endothelial growth Factor A and placental growth factor. In preeclamptic subjects, there will be an imbalance in anti-angiogenesis factors and there will be incomplete arterial transformation and cytotrophoblast cell division. Due to imbalance in sFlt levels in preeclamptic women it effects in the blood vessels by constriction and leads to endothelial dysfunction. This study aim is to compare the maternal serum concentration of sFlt levels in normotensive pregnant women to preeclamptic women in early and late gestational weeks. Material and Methods: Out of 300 participants in the case–control study, 150 were preeclamptic women as cases and 150 as normotensive pregnant women as controls participated in the present study. A 5 ml of maternal venous blood was collected; the serum was separated and stored at –800°C till the analysis. Using commercially available enzyme-linked immunosorbent assay (ELISA) kits from Chongqing Biospes Co., Ltd., (suppliers: Infobio Company, New Delhi) was measured with ELISA microplate reader at 450 nm (Merilyzer Eiaquant Company). Results: Out of 300 participants in the study, 46 pregnant women were early gestational weeks and 254 were late gestational weeks. The complications due to severe PE such as intrauterine death are 15%, intrauterine fetal growth retardation 33%, and premature 15%. The statistical analyses were performed by Statistical Packages for the Social Sciences Software 22. The area under the receiver operating characteristic curve is 0.82, with 91% sensitivity, and 79% specificity. The significance in the maternal serum sFlt levels was calculated by the Mann–Whitney U-test. By comparing the cases and controls, it was found that maternal serum sFlt1 were significantly higher in preeclamptic women with Z = 2.96 and U = 9021 with P = 0.005 significance. Conclusion: This is the first South Indian study. If we compare the sFlt1 levels in early and late gestational weeks, in late gestational weeks in controls and PE the levels were highly significant than early gestational weeks of PE and controls. Maternal serum sFlt can be used as a preeclamptic diagnostic marker in South Eastern Kolar population.

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VEGF and sFLT-1 in serum of PIH patients and effects on the foetus

Cited by 17 publications

References 30 publications

Levels of serum Hoxb3 and sFlt‐1 in pre‐eclamptic patients and their effects on pregnancy outcomes

Levels of serum Hoxb3 and sFlt‐1 in pre‐eclamptic patients and their effects on pregnancy outcomes

Maternal vascular endothelial growth factor receptor and interleukin levels in pregnant women with twin-twin transfusion syndrome

Association of sflt-1 as a maternal serum biomarker in preeclampsia: A case–control tertiary care hospital based study

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