VEGF-C mediates cyclic pressure-induced endothelial cell proliferation

Shin, Hainsworth Y.; Smith, Michael L.; Toy, Karen; Williams, P. Mickey; Bizios, Rena; Gerritsen, Mary E.

doi:10.1152/physiolgenomics.00068.2002

Cited by 39 publications

(40 citation statements)

References 28 publications

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“…This difference involves a significantly higher expression of VEGF-C and VEGF-D (19,20) in ductal breast cancer cells as compared with medullary breast cancer cells. Both these VEGFs have been described to induce proliferative responses in endothelial cells either alone or in combination with other stimuli (21,22). In our studies, both growth factors alone did not down-regulate ICAM-1 expression on HUVECs after longer time points.…”

Section: Discussionsupporting

confidence: 49%

Angiogenic Profile of Breast Carcinoma Determines Leukocyte Infiltration

Steege¹,

Baeten²,

Thijssen³

et al. 2004

Clinical Cancer Research

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Section: Discussionsupporting

confidence: 49%

Angiogenic Profile of Breast Carcinoma Determines Leukocyte Infiltration

Steege¹,

Baeten²,

Thijssen³

et al. 2004

Clinical Cancer Research

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“…The members of the VEGF family are VEGF-A, B, C, and D. VEGF C is regulating lymphangiogenesis. 28 In our studies, the normal the L/S ratio of VEGF was 5.3 and of VEGF C 1.3.…”

Section: Signaling Proteins In Tissue Fluid/lymphsupporting

confidence: 48%

Signaling Proteins Are Represented in Tissue Fluid/Lymph from Soft Tissues of Normal Human Legs at Concentrations Different from Serum

Zaleska

Wl²,

Durlik³

et al. 2013

Lymphatic Research and Biology

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Background: The mobile intercellular fluid flowing to and in the lymphatics contains filtered plasma products and substances synthesized and excreted by tissue cells. Among them are signaling proteins such as cytokines, chemokines, enzymes, and growth factors. They act locally in autocrine and paracrine systems regulating cell metabolism, proliferation, and formation of the ground matrix. They play an immunoregulatory role in infections, wound healing, and tumor cell growth. Methods and Results: In this study we measured the concentration of selected cytokines, chemokines, tissue enzymes, and growth factors in tissue fluid/lymph drained from normal human leg soft tissues. Legs exposed to infections and trauma often result in development of lymphedema. Lymph was drained from superficial calf lymphatics using microsurgical techniques. Our studies showed generally higher concentrations of cytokines, chemokines, enzymes, and growth factors in lymph than in serum. The total protein L/S ratio was 0.22, whereas that of various lymph signaling proteins ranged between 1 and 10. Conclusions: This indicates that in addition to proteins filtered from blood, local cells contribute to lymph concentration by own production, depending on the actual cell requirement. Moreover, there were major individual differences of lymph levels with simultaneous stable serum levels. This suggests existence of a local autonomous regulatory humoral mechanism in tissues, not reflected in serum.

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“…Both normal stress and shear stress will be determined since previous experimental evidence suggests that both may evoke a cellular response. 16,18 The fluid stress distributions on the plasma membrane provide the basis for analysis on how fluid stresses regulate the pseudopod extension/ retraction process.…”

Section: Introductionmentioning

confidence: 99%

Fluid Stresses on the Membrane of Migrating Leukocytes

Schmid‐Schönbein

2007

Ann Biomed Eng

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We recently demonstrated that migrating human leukocytes respond to normal physiologic fluid stresses (~1dyn/cm 2 ) by active control of local cytoplasmic extensions (pseudopods). To better understand the governing mechanisms of this response, we determined the fluid stress distributions on individual migrating leukocytes whose shapes were reconstructed with serial confocal microscopy. The flow over adherent leukocytes was computed by solution of the Stokes equation for plasma motion over the cell membrane. The fluid stresses are highest at the top of the cell and lowest in the substrate contact region. Pseudopods experience enhanced shear stresses but at lower values than at the top. Interestingly, leukocytes retract pseudopods in all regions and not only at sites with maximum fluid stresses. Therefore we hypothesized that sub-micron membrane folds (microvilli) serve to locally enhance the fluid stress on the cell. Using a separate model, we found that tips of microvilli experience greatly increased levels of stresses while the troughs between microvilli are shielded from fluid shear. This evidence suggests that the highly irregular shape of active leukocytes leads to fluid stresses that may stimulate local mechanosensory responses at many sites on the plasma membrane, even if they are located close to the cellsubstrate contact region.

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VEGF-C mediates cyclic pressure-induced endothelial cell proliferation

Abstract: sen. VEGF-C mediates cyclic pressure-induced endothelial cell proliferation.

Cited by 39 publications

References 28 publications

Angiogenic Profile of Breast Carcinoma Determines Leukocyte Infiltration

Angiogenic Profile of Breast Carcinoma Determines Leukocyte Infiltration

Signaling Proteins Are Represented in Tissue Fluid/Lymph from Soft Tissues of Normal Human Legs at Concentrations Different from Serum

Fluid Stresses on the Membrane of Migrating Leukocytes

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