VEGF‐D Correlates with Metastatic Disease in Gastric Cancer Patients Undergoing Surgery

Schimanski, Carl C.; Schlaegel, Friederike; Jordan, Mareike; Moehler, Markus; Sgourakis, George; Drescher, Daniel; Galle, Peter R.; Lang, Hauke; Gockel, Ines

doi:10.1007/s00268-011-1041-7

Cited by 14 publications

(10 citation statements)

References 44 publications

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“…VEGF‐D expression rate was higher in the adenocarcinoma group, but VEGF, VEGFR‐2, and VEGFR‐3 expression rates were not. In a survival analysis, the expression of VEGF‐D and VEGFR‐2 were associated with progressive disease and poor patient survival, consistent with previous reports . VEGF‐D expression was a prognostic factor for gastric adenocarcinoma in this study.…”

Section: Discussionsupporting

confidence: 91%

The prognostic significance of growth factors and growth factor receptors in gastric adenocarcinoma

Kim

Jeon

Bae

et al. 2012

APMIS

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We evaluated growth factors/receptors expression in gastric adenocarcinoma. Immunohistochemistry was used to evaluate epidermal growth factor receptor (EGFR), vascular endothelial growth factor (VEGF), VEGF-D, VEGF receptor (VEGFR)-2, VEGFR-3, transforming growth factor (TGF)-α, TGF-β1, and TGF-β-RII in tissue microarrays of adenocarcinoma, dysplasia, metaplasia, and gastritis. In adenocarcinoma, the expression rates of EGFR, VEGF, VEGF-D, VEGFR-2, VEGFR-3, TGF-α, TGF-β1, and TGF-β-RII were 2.0%, 0%, 10.7%, 4.4%, 11.2%, 26.3%, 9.4%, and 19.5%, respectively. VEGF-D, TGF-α, TGF-β1, and TGF-β-RII expression rate were higher in adenocarcinoma than in other groups. TGF-β-RII expression was correlated with VEGFR-3, VEGF-D, and TGF-α expression in adenocarcinomas. Tumor location, histologic type, stage, lymphatic invasion, perineural invasion, angioinvasion, VEGF-D, and VEGFR-2 expressions were associated with patient survival in a log rank test and advanced stage and positive expression of VEGF-D were poor prognostic factors using Cox analysis. VEGF-D expression may be of prognostic value in gastric adenocarcinoma, whereas EGFR and TGF family expression may only have a minor influence.

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Section: Discussionsupporting

confidence: 91%

The prognostic significance of growth factors and growth factor receptors in gastric adenocarcinoma

Kim

Jeon

Bae

et al. 2012

APMIS

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show abstract

“…In addition, vegf-d -null mice displayed a reduction in peritumoral lymphangiogenesis and lymph node metastasis in an orthotopic pancreatic tumor model [100]. Analysis of VEGF-C and -D expression level in excised patient tumor tissues revealed that levels of these growth factors are associated with poor outcome and lymph node metastasis [101–103]. …”

Section: Lymphangiogenesis and Tumor Metastasismentioning

confidence: 99%

Tumor Lymphangiogenesis as a Potential Therapeutic Target

Duong

Koopman

François

2012

Journal of Oncology

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Metastasis the spread of cancer cells to distant organs, is the main cause of death for cancer patients. Metastasis is often mediated by lymphatic vessels that invade the primary tumor, and an early sign of metastasis is the presence of cancer cells in the regional lymph node (the first lymph node colonized by metastasizing cancer cells from a primary tumor). Understanding the interplay between tumorigenesis and lymphangiogenesis (the formation of lymphatic vessels associated with tumor growth) will provide us with new insights into mechanisms that modulate metastatic spread. In the long term, these insights will help to define new molecular targets that could be used to block lymphatic vessel-mediated metastasis and increase patient survival. Here, we review the molecular mechanisms of embryonic lymphangiogenesis and those that are recapitulated in tumor lymphangiogenesis, with a view to identifying potential targets for therapies designed to suppress tumor lymphangiogenesis and hence metastasis.

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“…Despite the fact that most cases of early stage gastric carcinoma can be cured by surgical resection, metastasis contributes to the high rate of mortality in gastric carcinoma [7]. Although numerous immunohistochemical markers such as human epidermal growth factor receptor 2, matrix metallopeptidase-2, and epithelium cadherin have been recognized as biomarkers in other types of cancer, these markers are not commonly used to assess biological behavior and prognosis in gastric cancer because of low levels of sensitivity and specificity [8][9][10][11][12][13]. Therefore, there is an urgent need to identify novel prognostic and predictive biomarkers to improve the diagnosis and clinical management of patients with gastric cancer, which in turn may help to develop more effective treatment strategies.…”

Section: Introductionmentioning

confidence: 99%

An abnormally high expression of ISL-1 represents a potential prognostic factor in gastric cancer

et al. 2015

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VEGF‐D Correlates with Metastatic Disease in Gastric Cancer Patients Undergoing Surgery

Cited by 14 publications

References 44 publications

The prognostic significance of growth factors and growth factor receptors in gastric adenocarcinoma

The prognostic significance of growth factors and growth factor receptors in gastric adenocarcinoma

Tumor Lymphangiogenesis as a Potential Therapeutic Target

An abnormally high expression of ISL-1 represents a potential prognostic factor in gastric cancer

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