VEGF expression and microvascular density in relation to high-risk-HPV infection in cervical carcinoma – An immunohistochemical study

Sabaa, Bassma M. El; Meleiss, Mahmoud; Zaki, Inass

doi:10.1016/j.ajme.2011.12.001

Cited by 5 publications

(4 citation statements)

References 56 publications

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“…Activation of VEGF promotes endothelial cell proliferation and migration, favoring formation of new blood vessels and increasing permeability of existing blood vessels [135] . Associated with those findings, increased micro vessel density was reported in CIN3 and cervical cancer [ 136 , 137 ] ( Fig. 2 ).…”

Section: In Situ Presence Of Leukocytes In Human Cervical Intraepithesupporting

confidence: 54%

In situ immunopathological events in human cervical intraepithelial neoplasia and cervical cancer: Review

Carrero

Callejas

Mosquera

2021

Translational Oncology

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Highlights Neoplasia of the cervix is one of the most frequent in women. Immunological impairment in cervical intraepithelial neoplasia and cancer have been reported. In-situ expression of cytokines and leukocytes during the cervical neoplasia occurs. Some of these cytokines can prevent or induce the progression of the neoplasm. Possible role in therapeutics of cervical cancer by cytokine manipulations need to be evaluated.

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Section: In Situ Presence Of Leukocytes In Human Cervical Intraepithesupporting

confidence: 54%

In situ immunopathological events in human cervical intraepithelial neoplasia and cervical cancer: Review

Carrero

Callejas

Mosquera

2021

Translational Oncology

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“…This study is increasingly important as we have HPV vaccines able to guarantee excellent prevention and control of this viral infection and its consequences in terms of tumour development. Moreover, the correlation between HPV infection and angiogenesis [ 11 – 13 ] offers a good rationale to treat a specific subgroup of prostate cancer patients selected on the basis of the HPV status by using antiangiogenic agents, whose efficacy has recently been reported for the treatment of advanced cervical cancer [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

“…Normally, this condition leads to p53-dependent apoptosis, but HPV has evolved to inhibit the tumour suppressor p53 functions, indirectly by inducing its ubiquitylation and proteasomal degradation or directly by binding p53 interfering with its transcriptional activity. Moreover, HPV oncoproteins contribute to the progressive expansion of tumours by stimulating proangiogenic cytokines, especially VEGF (vascular endothelial growth factor), responsible for the recruitment of new blood vessel capillaries from preexisting mature vessels [ 11 – 13 ]. Besides those, several other E7 and E6 transforming activities (reviewed in [ 9 , 10 ]), probably assisted by HPV E5, contribute to maintaining a high proliferative and inhibited apoptosis state that leads to the accumulation of mutations and genomic instability in persistently infected cells, which results in full malignant progression and cancer development.…”

Section: Introductionmentioning

confidence: 99%

Is Human Papillomavirus Associated with Prostate Cancer Survival?

et al. 2013

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The role of human papillomavirus (HPV) in prostate carcinogenesis is highly controversial: some studies suggest a positive association between HPV infection and an increased risk of prostate cancer (PCa), whereas others do not reveal any correlation. In this study, we investigated the prognostic impact of HPV infection on survival in 150 primary PCa patients. One hundred twelve (74.67%) patients had positive expression of HPV E7 protein, which was evaluated in tumour tissue by immunohistochemistry. DNA analysis on a subset of cases confirmed HPV infection and revealed the presence of genotype 16. In Kaplan-Meier analysis, HPV-positive cancer patients showed worse overall survival (OS) (median 4.59 years) compared to HPV-negative (median 8.24 years, P = 0.0381). In multivariate analysis age (P < 0.001), Gleason score (P < 0.001), nuclear grading (P = 0.002), and HPV status (P = 0.034) were independent prognostic factors for OS. In our cohort, we observed high prevalence of HPV nuclear E7 oncoprotein and an association between HPV infection and PCa survival. In the debate about the oncogenic activity of HPV in PCa, our results further confirm the need for additional studies to clarify the possible role of HPV in prostate carcinogenesis.

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“…Neoangiogenesis can be assessed from micro vascular density (MVD) (Chabowski et al 2018, Grivas et al 2016. MVD is a measure of tumor neoangiogenesis and a significant prognostic factor correlated with an increased probability of metastasis and a worse prognosis in many tumor types, including mCRC (El Sabaa et al 2012). According to a study by Liang et al (2004), and Anannamcharoen and Nimmanon (2012), MVD has a better prognostic value than VEGF in assessing angiogenesis on mCRC.…”

Section: Abstrakmentioning

confidence: 99%

Examination of Micro Vascular Density on Metastatic Colorectal Cancer of RAS Mutant-Type as Anti Vegf Therapy Predictor

Sulistyo

Budipramana

2021

FMI

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According to the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) on Colon Cancer Version 2.2019, mCRC patients with mutant type RAS were treated with anti-VEGF. However, the use of the targeting therapy still had inconsistent results. Neoangiogenesis studies had been used as a basis to assess the prognosis of mCRC. Microvascular density (MVD) had become the morphological gold standard to assess neovascularization in human tumors. This study proved the existence of low microvascular density (MVD) in mCRC patients with mutant type RAS status as a predictor of failure of anti-VEGF therapy. There were 29 patients at Dr. Soetomo Academic Hospital from 2015-2018 who had their RAS status checked and tested for microvascular density (MVD). The results of this study were analyzed using SPSS 23.0. In the Mutant-type of RAS group, this study examined microvascular density (MVD). 11 (73%) research subjects with high MVD scores and 4 (27%) research subjects had low MVD scores. Besides, 27% microvascular density (MVD) was low, in the mutant-type of RAS mCRC patient which could be a predictor factor for the failure of anti-VEGF therapy.

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VEGF expression and microvascular density in relation to high-risk-HPV infection in cervical carcinoma – An immunohistochemical study

Cited by 5 publications

References 56 publications

In situ immunopathological events in human cervical intraepithelial neoplasia and cervical cancer: Review

In situ immunopathological events in human cervical intraepithelial neoplasia and cervical cancer: Review

Is Human Papillomavirus Associated with Prostate Cancer Survival?

Examination of Micro Vascular Density on Metastatic Colorectal Cancer of RAS Mutant-Type as Anti Vegf Therapy Predictor

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