VEGF receptor signaling links inflammation and tumorigenesis in colitis-associated cancer

Waldner, Maximilian J.; Wirtz, Stefan; Jefremow, André; Warntjen, Moritz; Neufert, Clemens; Atreya, Raja; Becker, Christoph; Weigmann, Benno; Vieth, Michael; Rose-John, Stefan; Neurath, Markus F.

doi:10.1084/jem.20100438

Cited by 146 publications

(74 citation statements)

References 52 publications

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“…Whereas the pro-angiogenic effects of VEGF have been studied extensively, only recent data propose VEGF as an auto-/paracrine growth factor for tumor cells 8,9 .…”

Section: Discussionmentioning

confidence: 99%

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VEGFR2 Signaling Prevents Colorectal Cancer Cell Senescence to Promote Tumorigenesis in Mice With Colitis

et al. 2015

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“…Whereas the pro-angiogenic effects of VEGF have been studied extensively, only recent data propose VEGF as an auto-/paracrine growth factor for tumor cells 8,9 .…”

Section: Discussionmentioning

confidence: 99%

“…Among others, this was studied for breast cancer cells 6 , skin cancer cells 7 , CD133+ glioblastoma stem cells 8 and in colitis-associated carcinogenesis 9 .…”

Section: Introductionmentioning

confidence: 99%

VEGFR2 Signaling Prevents Colorectal Cancer Cell Senescence to Promote Tumorigenesis in Mice With Colitis

et al. 2015

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“…Inflammation is also involved in TLR4-dependent, colitis-promoted tumor growth via upregulation of nuclear factor (NF)-κB and several tumorigenic pro-inflammatory cytokines (e.g., IL1β, IL6 and TNFα) in lamina propria myeloid cells. In turn, these cytokines can regulate the expression of genes associated with tumor cell survival and proliferation [6][7][8]. One study shows that knockout of NF-κB in myeloid cells results in reductions in both tumor size and tumor number in azoxymethane (AOM)/dextran sodium sulfate (DSS)-treated mice [9].…”

Section: Introductionmentioning

confidence: 99%

Therapeutic effect of hydroxychloroquine on colorectal carcinogenesis in experimental murine colitis

Yao

Xie

et al. 2016

Biochemical Pharmacology

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“…VEGFR-2 is critical for VEGF-mediated tumor angiogenesis and lymphangiogenesis [18,19], and its expression is associated with tumor invasion and metastasis [14,20,29,30]. A VEGFR-2 antagonist can significantly inhibit VEGFinduced tumor growth and metastasis [31].…”

Section: Discussionmentioning

confidence: 99%

Gab1 regulates proliferation and migration through the PI3K/Akt signaling pathway in intrahepatic cholangiocarcinoma

Sang

et al. 2015

Tumor Biol.

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Intrahepatic cholangiocarcinoma is the second most common primary malignant tumor of the liver, and it originates from the intrahepatic biliary duct epithelium. Prognosis is poor due to lack of effective comprehensive treatments. In this study, we assessed the expression of Gab1, VEGFR-2, and MMP-9 in intrahepatic cholangiocarcinoma solid tumors by immunohistochemistry and determined whether their expression was associated with clinical and pathological features. We found that expression of Gab1, VEGFR-2, and MMP-9 was highly and positively correlated with each other and with lymph node metastasis and TNM stage in intrahepatic cholangiocarcinoma tissues. Interference of Gab1 and VEGFR-2 expression via siRNA in the intrahepatic cholangiocarcinoma cell line RBE resulted in decreased PI3K/Akt pathway activity. Inhibition of Gab1 and VEGFR-2 expression also caused decreased cell proliferation, cell cycle arrested in G1 phase, increased apoptosis, and decreased invasion in RBE cells. These results suggest that Gab1, VEGFR-2, and MMP-9 contribute significantly to the highly malignant behavior of intrahepatic cholangiocarcinoma. The regulation of growth, apoptosis, and invasion by Gab1 through the VEGFR-2/Gab1/PI3K/Akt signaling pathway may represent potential targets for improving the treatment of intrahepatic cholangiocarcinoma.

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VEGF receptor signaling links inflammation and tumorigenesis in colitis-associated cancer

Abstract: Inflammation drives expression of VEGFR2, which is expressed on and drives growth of tumor cells in colitis-associated cancer.

Cited by 146 publications

References 52 publications

VEGFR2 Signaling Prevents Colorectal Cancer Cell Senescence to Promote Tumorigenesis in Mice With Colitis

VEGFR2 Signaling Prevents Colorectal Cancer Cell Senescence to Promote Tumorigenesis in Mice With Colitis

Therapeutic effect of hydroxychloroquine on colorectal carcinogenesis in experimental murine colitis

Gab1 regulates proliferation and migration through the PI3K/Akt signaling pathway in intrahepatic cholangiocarcinoma

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