VEGFA rs2010963 GG genotype is associated with superior adaptations to resistance versus endurance training in the same group of healthy, young men

Abstract

Purpose We used a within-subject, cross-over study to determine the relationship between the intra-individual adaptations to four weeks’ resistance (RT) versus four weeks’ endurance (END) training, and we investigated whether three single nucleotide polymorphisms (SNPs) were associated with these adaptations. Methods Thirty untrained, healthy, young men completed a cycling test to exhaustion to determine peak oxygen uptake (V̇O2peak), and a knee extension (KE) maximum voluntary isometric contraction (MVIC) of the right leg before and after four weeks’ supervised RT (four sets of 10 repetitions at 80% single repetition maximum unilateral KE exercise, three times weekly) and four weeks’ supervised END (30 min combined continuous/interval cycling, three times weekly), separated by a three-week washout phase. Participants were genotyped for the ACTN3 rs1815739, NOS3 rs2070744 and VEGFA rs2010963 SNPs. Results The intra-individual adaptations regarding percentage changes in MVIC force and V̇O2peak following RT and END, respectively, were unrelated (r2 = 0.003; P = 0.79). However, a VEGFA genotype × training modality interaction (P = 0.007) demonstrated that VEGFA GG homozygotes increased their MVIC force after RT (+ 20.9 ± 13.2%) more than they increased their V̇O2peak after END (+ 8.4 ± 9.1%, P = 0.005), and more than VEGFA C-allele carriers increased their MVIC force after RT (+ 12.2 ± 8.1%, P = 0.04). There were no genotype × training modality interactions for the ACTN3 or NOS3 SNPs. Conclusion High/low responders to RT were not consequently high/low responders to END or vice versa. However, preferential adaptation of VEGFA rs2010963 GG homozygotes to RT over END, and their greater adaptation to RT compared to VEGFA C-allele carriers, indicate a novel genetic predisposition for superior RT adaptation.

Creatine Supplementation and Resistance Training in Patients With Breast Cancer (CaRTiC Study)

“…36 The multifactorial triggering characteristic of sarcopenia makes it essential to address the study of genetic variability taking into account not only polymorphisms in genes associated with training response such as those widely described in ACTN3, 37,38 ACE, 39,40 NOS3, 41 PPARGC1A and PPARGC1B, 42 VEGFA, 43 etc. but also including polymorphic variables associated with variability in a patient's response to inflammation (CRP, IL6), 44 capacity to respond to oxidative damage (SOD2, CAT, GPX), 45 cellular (CASP, MMP3) 46 and tissue regeneration capacity (GDF5, TNC), 47 as well as their nutrigenomic aspects that may modify their hypertrophic response to training such as polymorphisms associated with lipid metabolism (FAP2, ADBR, UCP2, etc. ), insulin secretion (GCKR, ADCY5, GIPR, etc.).…”