Understanding the behaviour of traffic participants within the geo‐spatial context of road/intersection topology is a vital prerequisite for any smart ITS application. This article presents a video‐based traffic analysis and anomaly detection system covering the complete data processing pipeline, including sensor data acquisition, analysis, and digital twin reconstruction. The system solves the challenge of geo‐spatial mapping of captured visual data onto the road/intersection topology by semantic analysis of aerial data. Additionally, the automated camera calibration component enables instant camera pose estimation to map traffic agents onto the road/intersection surface accurately. A novel aspect is approaching the anomaly detection problem by AI analysis of both the spatio‐temporal visual clues and the geo‐spatial trajectories for all type of traffic participants, such as pedestrians, bicyclists, and vehicles. This enables recognition of anomalies related to either traffic‐rule violations, for example, jaywalking, improper turns, zig‐zag driving, unlawful stops, or behavioural anomalies: littering, accidents, falling, vandalism, violence, infrastructure collapse etc. The method achieves leading anomaly detection results on benchmark datasets World Cup 2014, UCF‐Crime, XD‐Violence, and ShanghaiTech. All the obtained results are streamed and rendered in real‐time by the developed TGX digital twin visualizer. The complete system has been deployed and validated on the roads of Helmond town in The Netherlands.