Vein-first Lobectomy for Lung Cancer Assessed According to the Status of Clustered Circulating Tumour Cells

Abstract

Background/Aim: Vein-first lobectomy (VFL) in lung cancer might reduce shedding of circulating tumour cells (CTCs). This study assessed the clinical significance of VFL. Patients and Methods: Lung cancer patients undergoing lobectomy and CTC testing were evaluated. The primary evaluation item was postoperative clustered CTC detection, and the secondary outcome measures were the 2-year overall survival and recurrence-free survival rates according to the status of VFL and postoperative clustered CTC. Results: Eighty-six patients with similar backgrounds, except for lobe resection and pulmonary vein dissection time, showed postoperative clustered CTC identification rates of 43.8% and 37.9% in the VFL group (n=57) and no-VFL group (n=29), respectively. However, prognosis was not significantly different, although the presence of clustered CTC after surgery was a predictor of recurrence. Conclusion: The status of postoperative clustered CTC was similar regardless of VFL or not, although the detection of clustered CTC was a predictor of recurrence.

Analysis of diagnostic value of CTC and CTDNA in early lung cancer

“…4 million patients die every year, making it the leading cause of death of Chinese residents due to malignant tumors (1). Lung cancer falls into small cell lung cancer and non-small cell lung cancer (NSCLC) according to pathological classification, among which NSCLC takes the proportion of 85% of lung cancer (2). Due to the atypical early clinical symptoms, most sufferers were in the advanced stage when clinically diagnosed, and lost the chance of surgical resection, thus leading to a low 5-year overall survival rate (3,4).…”