Velocity-map imaging of photoelectron circular dichroism in non-volatile molecules using a laser-based desorption source

Abstract

We present an initial demonstration of a velocity-map imaging (VMI) experiment using a back-irradiation laser-based desorption source directly integrated into the electrode assembly.

Fast and precise chiroptical spectroscopy by photoelectron elliptical dichroism

“…Several photoelectron circular dichroism measurements of amino acids have recently been reported. 30,33,[49][50][51][52][53] Here we investigate the interest of PEELD measurements in small amino acids.…”

“…54,55 The precision of the measurements could be improved by producing a denser jet of molecules, for instance using laser-based desorption. 53,56…”

High-throughput UV-photofragmentation studies of thymine and guanine

“…27 Hence the desorption mechanism in LBTD cannot be impulse-driven, but is considered purely thermal. It is a unique technique that allows efficient and soft desorption of a sample into the gas phase as intact neutral molecules, [28][29][30] in contrast to conventional desorption/ionisation techniques for nonvolatiles such as matrix-assisted laser desorption ionisation, 31 electrospray ionisation, 32 or desorption electrospray ionisation 33 which produce ions. LBTD is also significantly 'softer' than conventional laser desorption involving direct irradiation of the sample matrix, 34 which can often lead to significant fragmentation and contamination of the molecular sample.…”

Vaporization of Intact Neutral Biomolecules Using Laser-Based Thermal Desorption

“…The LBTD approach has now been implemented by a number of groups around the world, and has successfully vaporized nucleobases, , amino acids, − and nucleosides. , Related approaches that use a glass surface instead of a metal substrate have also been demonstrated for desorption of nanoparticles or phthalocyanine molecules …”