Velocity map imaging using an in-vacuum pixel detector

Gademann, G.; Huismans, Ymkje; Gijsbertsen, A.; Jungmann, Julia H.; Visschers, J.L.; Vrakking, Marc J. J.

doi:10.1063/1.3246811

Cited by 25 publications

(23 citation statements)

References 27 publications

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“…The MCP, phosphor screen, CCD camera combination is used for microprobe mode MSI and velocity map imaging experiments . Pixelated detectors with a semiconductor sensor layer are used for velocity map imaging . An MCP in combination with a bare pixelated detector is used for MSI …”

Section: State‐of‐the‐art In Multi‐dimensional Ion Electron Photon mentioning

confidence: 99%

Detection systems for mass spectrometry imaging: A perspective on novel developments with a focus on active pixel detectors

Jungmann

Heeren

2012

Rapid Comm Mass Spectrometry

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Instrumental developments for imaging and individual particle detection for biomolecular mass spectrometry (imaging) and fundamental atomic and molecular physics studies are reviewed. Ion-counting detectors, array detection systems and high mass detectors for mass spectrometry (imaging) are treated. State-of-the-art detection systems for multidimensional ion, electron and photon detection are highlighted. Their application and performance in three different imaging modes -integrated, selected and spectral image detection -are described. Electro-optical and microchannelplate-based systems are contrasted. The analytical capabilities of solid-state pixel detectors -both charge coupled device (CCD) and complementary metal oxide semiconductor (CMOS) chips -are introduced. The Medipix/Timepix detector family is described as an example of a CMOS hybrid active pixel sensor. Alternative imaging methods for particle detection and their potential for future applications are investigated.

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Section: State‐of‐the‐art In Multi‐dimensional Ion Electron Photon mentioning

confidence: 99%

Detection systems for mass spectrometry imaging: A perspective on novel developments with a focus on active pixel detectors

Jungmann

Heeren

2012

Rapid Comm Mass Spectrometry

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“…The reader should note that the observed artifact is characteristic for potential effect detector like the IonCCD only, since such detectors are sensitive to the charge of the incoming particle. Other pixel detectors such as Medipix/Timepix [28] detectors that are of kinetic effect type rely solely on the impact energy of the particle inducing electron-hole pairs necessary for particle detection. Because of the typically high thresholds (94 keV), secondary electrons would not be detected as their kinetic energies lie in the sub 10 eV range.…”

Section: Resultsmentioning

confidence: 99%

“…A detector family that is rapidly gaining importance employs the emerging technology of pixilated array detectors such as Medipix/Timepix (developed by CERN and the Nikhef Institute in Amsterdam) for X-ray detection [27], velocity mapping imaging [28], and for mass spectrometric applications [29].…”

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confidence: 99%

IonCCD Detector for Miniature Sector-Field Mass Spectrometer: Investigation of Peak Shape and Detector Surface Artifacts Induced by keV Ion Detection

Hadjar

Schlathölter

Davila

et al. 2011

J. Am. Soc. Mass Spectrom.

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A recently described ion charge coupled device detector IonCCD (Sinha and Wadsworth, Rev. Sci. Instrum. 76(2), 2005; Hadjar, J. Am. Soc. Mass Spectrom. 22(4), [612][613][614][615][616][617][618][619][620][621][622][623][624] 2011) is implemented in a miniature mass spectrometer of sector-field instrument type and MattauchHerzog (MH)-geometry (Rev. Sci. Instrum. 62(11), 2618-2620, 1991; Burgoyne, Hieftje and Hites J. Am. Soc. Mass Spectrom. 8(4), 307-318, 1997; Nishiguchi, Eur. J. Mass Spectrom. 14 (1), 7-15, 2008) for simultaneous ion detection. In this article, we present first experimental evidence for the signature of energy loss the detected ion experiences in the detector material. The two energy loss processes involved at keV ion kinetic energies are electronic and nuclear stopping. Nuclear stopping is related to surface modification and thus damage of the IonCCD detector material. By application of the surface characterization techniques atomic force microscopy (AFM) and X-ray photoelectrons spectroscopy (XPS), we could show that the detector performance remains unaffected by ion impact for the parameter range observed in this study. Secondary electron emission from the (detector) surface is a feature typically related to electronic stopping. We show experimentally that the properties of the MH-mass spectrometer used in the experiments, in combination with the IonCCD, are ideally suited for observation of these stopping related secondary electrons, which manifest in reproducible artifacts in the mass spectra. The magnitude of the artifacts is found to increase linearly as a function of detected ion velocity. The experimental findings are in agreement with detailed modeling of the ion trajectories in the mass spectrometer. By comparison of experiment and simulation, we show that a detector bias retarding the ions or an increase of the B-field of the IonCCD can efficiently suppress the artifact, which is necessary for quantitative mass spectrometry.

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“…In vacuum pixel detectors that allow for position- [17,18] and time-resolved [18][19][20] photoelectron and ion imaging have been increasingly used in the past few years in biological, biomolecular, and biomedical MS imaging (MSI). Previously, the use of the Timepix detector with other MS technologies such as secondary ion mass spectrometry (SIMS) [21] and a TOF instrument [22,23] has been demonstrated for MSI with a spatial resolution of few micrometers.…”

Section: Introductionmentioning

confidence: 99%

Experimental Investigation of the 2D Ion Beam Profile Generated by an ESI Octopole-QMS System

Syed

Eijkel

Kistemaker

et al. 2014

J. Am. Soc. Mass Spectrom.

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In this paper, we have employed an ion imaging approach to investigate the behavior of ions exiting from a quadrupole mass spectrometer (QMS) system that employs a radio frequency octopole ion guide before the QMS. An in-vacuum active pixel detector (Timepix) is employed at the exit of the QMS to image the ion patterns. The detector assembly simultaneously records the ion impact position and number of ions per pixel in every measurement frame. The transmission characteristics of the ion beam exiting the QMS are studied using this imaging detector under different operating conditions. Experimental results confirm that the ion spatial distribution exiting the QMS is heavily influenced by ion injection conditions. Furthermore, ion images from Timepix measurements of protein standards demonstrate the capability to enhance the quality of the mass spectral information and provide a detailed insight in the spatial distribution of different charge states (and hence different m/z) ions exiting the QMS.

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Velocity map imaging using an in-vacuum pixel detector

Cited by 25 publications

References 27 publications

Detection systems for mass spectrometry imaging: A perspective on novel developments with a focus on active pixel detectors

Detection systems for mass spectrometry imaging: A perspective on novel developments with a focus on active pixel detectors

IonCCD Detector for Miniature Sector-Field Mass Spectrometer: Investigation of Peak Shape and Detector Surface Artifacts Induced by keV Ion Detection

Experimental Investigation of the 2D Ion Beam Profile Generated by an ESI Octopole-QMS System

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