Venereal Transmission of La Crosse (California encephalitis) Arbovirus in
            <i>Aedes triseriatus</i>
            Mosquitoes

Thompson, Wayne H.; Beaty, Barry J.

doi:10.1126/science.850794

Cited by 90 publications

(45 citation statements)

References 9 publications

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“…Notably, for the maintenance of insect-restricted viruses in nature, insect cycles involving horizontal (transvenereal) and vertical (transovarial) transmission are necessary. For instance, transovarial and transvenereal transmission to up to 30% of arthropod offspring has been described for bunyaviruses (62)(63)(64). Some viruses can be maintained in overwintering vectors or during time periods with a low density of amplifying hosts (65,66).…”

Section: Discussionmentioning

confidence: 99%

Discovery of a Unique Novel Clade of Mosquito-Associated Bunyaviruses

Marklewitz

Zirkel

Rwego

et al. 2013

J Virol

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Section: Discussionmentioning

confidence: 99%

Discovery of a Unique Novel Clade of Mosquito-Associated Bunyaviruses

Marklewitz

Zirkel

Rwego

et al. 2013

J Virol

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“…This phenomenon has been studied in several vector species and demonstrated in mosquito vectors for bunyaviruses, alphaviruses, flaviviruses, and rhabdoviruses. [14][15][16][17][18][19] However, no information is available for CHIKV venereal transmission in mosquitoes. Our data demonstrating approximately 17% positivity in female mosquitoes when coinhabited with experimentally infected males is an important observation and may have immense epidemiologic significance.…”

Section: Discussionmentioning

confidence: 99%

Venereal Transmission of Chikungunya Virus by Aedes aegypti Mosquitoes (Diptera: Culicidae)

Mavale¹,

Parashar²,

Sudeep³

et al. 2010

The American Society of Tropical Medicine and Hygiene

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Experiments were conducted to demonstrate the role of male Aedes aegypti mosquitoes in the maintenance and transmission of chikungunya virus (CHIKV) to female mosquitoes. We demonstrated that infected male mosquitoes are capable of infecting females during mating. The infection rate in female mosquitoes was 11% when virgin female mosquitoes were allowed to coinhabit with infected males. The body suspension of venereally infected female mosquitoes induced illness in infant Swiss albino mice, which demonstrated the infectivity of the venereally transmitted virus. The presence of CHIKV in the brains of the ill mice was confirmed by a reverse transcription–polymerase chain reaction specific for partial sequences of nonstructural protein 4 and envelope 1 genes. In the light of the recent report of transovarial transmission of CHIKV in mosquitoes, although at a lower level, this finding has significance because it may help in transmission of the virus to females venereally to start a new infection cycle.

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“…13,14 This arbovirus is maintained in hardwood forests largely through Aedes triseriatus transovarial vertical transmission. 15,16 In fact, the primary LACV vector can overwinter the virus in tree holes. 17 However, vertical transmission alone is insufficient to maintain LACV in nature, 15 and thus horizontal transmission between mosquito vectors and sciurid rodents (i.e., chipmunks, squirrels) 18 is essential for LACV to persist in the environment and to maintain its ability to amplify successfully in vertebrate hosts.…”

Section: Introductionmentioning

confidence: 99%

“…15 Finally, horizontal transmission of LACV can also occur via Ae. triseriatus venereal transmission, 16 but this route is thought to represent a small contribution to LACV transmission.…”

Section: Introductionmentioning

confidence: 99%

La Crosse Virus Field Detection and Vector Competence of Culex Mosquitoes

Harris

Yang

Jackson

et al. 2015

The American Society of Tropical Medicine and Hygiene

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Abstract. La Crosse virus (LACV), a leading cause of arboviral pediatric encephalitis in the United States, is emerging in Appalachia. Here, we report field and laboratory evidence that suggest LACV may be using Culex mosquitoes as additional vectors in this region. This bunyavirus was detected by reverse-transcriptase polymerase chain reaction in two pools of Culex mosquitoes in southwestern Virginia and in six pools in West Virginia. To assess vector competence, we offered LACV blood meals to field-collected Culex restuans Theobald, Cx. pipiens L., and Aedes triseriatus (Say). Both Culex species were susceptible to infection. LACV-positive salivary expectorate, indicative of the ability to transmit, was detected in a small proportion of Cx. restuans (9%) and Cx. pipiens (4%) compared with Ae. triseriatus (40%). In a companion study of Cx. restuans only, we found that adults derived from nutritionally stressed larvae were significantly more likely to disseminate and transmit LACV. Our results indicate a potential role of Culex spp. in LACV dynamics that should be explored further in endemic areas.

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Venereal Transmission of La Crosse (California encephalitis) Arbovirus in Aedes triseriatus Mosquitoes

Cited by 90 publications

References 9 publications

Discovery of a Unique Novel Clade of Mosquito-Associated Bunyaviruses

Discovery of a Unique Novel Clade of Mosquito-Associated Bunyaviruses

Venereal Transmission of Chikungunya Virus by Aedes aegypti Mosquitoes (Diptera: Culicidae)

La Crosse Virus Field Detection and Vector Competence of Culex Mosquitoes

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