Veno‐occlusive disease of the liver associated with chronic myelomonocytic leukemia treated with vincristine and standard doses of cytarabine

Boula, Anna; Mantadakis, Elpis; Xilouri, Irini; Christoforidou, Anna; Foudoulakis, A; Samonis, George

doi:10.1002/ajh.20338

Cited by 9 publications

(1 citation statement)

References 15 publications

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“…As well as exposure to dehydroPAs, another clinically recognized and common cause of dehydroPA-like HSOS is associated with chemotherapy of childhood cancers such as rhabdomyosarcoma (RMS), nephroblastoma (Wilms tumor), metastatic colorectal cancer, and leukemia using alkylating agents such as cyclophosphamide or busulfan. − Treatment of hematologic cancers in neonates by allogenic stem cell transplantation (SCT) following myeloablation using these agents can also cause HSOS as a complication. − …”

Section: Possible Indicators Of Dehydropyrrolizidine Alkaloid Involve...mentioning

confidence: 99%

Pyrrolizidine Alkaloids: Potential Role in the Etiology of Cancers, Pulmonary Hypertension, Congenital Anomalies, and Liver Disease

Edgar

Molyneux

Colegate

2014

Chem. Res. Toxicol.

179

169

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Large outbreaks of acute food-related poisoning, characterized by hepatic sinusoidal obstruction syndrome, hemorrhagic necrosis, and rapid liver failure, occur on a regular basis in some countries. They are caused by 1,2-dehydropyrrolizidine alkaloids contaminating locally grown grain. Similar acute poisoning can also result from deliberate or accidental consumption of 1,2-dehydropyrrolizidine alkaloid-containing herbal medicines, teas, and spices. In recent years, it has been confirmed that there is also significant, low-level dietary exposure to 1,2-dehydropyrrolizidine alkaloids in many countries due to consumption of common foods such as honey, milk, eggs, salads, and meat. The level of 1,2-dehydropyrrolizidine alkaloids in these foods is generally too low and too intermittent to cause acute toxicity. However, these alkaloids are genotoxic and can cause slowly developing chronic diseases such as pulmonary arterial hypertension, cancers, cirrhosis, and congenital anomalies, conditions unlikely to be easily linked with dietary exposure to 1,2-dehydropyrrolizidine alkaloids, especially if clinicians are unaware that such dietary exposure is occurring. This Perspective provides a comprehensive review of the acute and chronic toxicity of 1,2-dehydropyrrolizidine alkaloids and their potential to initiate certain chronic diseases, and suggests some associative considerations or indicators to assist in recognizing specific cases of diseases that may have resulted from dietary exposure to these hazardous natural substances. If it can be established that low-level dietary exposure to 1,2-dehydropyrrolizidine alkaloids is a significant cause of some of these costly and debilitating diseases, then this should lead to initiatives to reduce the level of these alkaloids in the food chain.

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Section: Possible Indicators Of Dehydropyrrolizidine Alkaloid Involve...mentioning

confidence: 99%

Pyrrolizidine Alkaloids: Potential Role in the Etiology of Cancers, Pulmonary Hypertension, Congenital Anomalies, and Liver Disease

Edgar

Molyneux

Colegate

2014

Chem. Res. Toxicol.

179

169

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Sinusoidal obstruction syndrome during induction therapy for acute lymphoblastic leukemia managed with N‐acetyl Cysteine

Sahoo

Sharma

2011

Pediatric Blood & Cancer

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Current awareness: Pharmacoepidemiology and drug safety

2005

Pharmacoepidemiology and Drug

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In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of pharmacoepidemiology and drug safety. Each bibliography is divided into 20 sections: 1 Books, Reviews & Symposia; 2 General; 3 Anti‐infective Agents; 4 Cardiovascular System Agents; 5 CNS Depressive Agents; 6 Non‐steroidal Anti‐inflammatory Agents; 7 CNS Agents; 8 Anti‐neoplastic Agents; 9 Haematological Agents; 10 Neuroregulator‐Blocking Agents; 11 Dermatological Agents; 12 Immunosuppressive Agents; 13 Autonomic Agents; 14 Respiratory System Agents; 15 Neuromuscular Agents; 16 Reproductive System Agents; 17 Gastrointestinal System Agents; 18 Anti‐inflammatory Agents ‐ Steroidal; 19 Teratogens/fetal exposure; 20 Others. Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted.

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Veno‐occlusive disease of the liver associated with chronic myelomonocytic leukemia treated with vincristine and standard doses of cytarabine

Cited by 9 publications

References 15 publications

Pyrrolizidine Alkaloids: Potential Role in the Etiology of Cancers, Pulmonary Hypertension, Congenital Anomalies, and Liver Disease

Pyrrolizidine Alkaloids: Potential Role in the Etiology of Cancers, Pulmonary Hypertension, Congenital Anomalies, and Liver Disease

Sinusoidal obstruction syndrome during induction therapy for acute lymphoblastic leukemia managed with N‐acetyl Cysteine

Current awareness: Pharmacoepidemiology and drug safety

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