May-Thurner syndrome (MTS) is a rarely diagnosed condition that occurs when the right common iliac artery (RCIA) compresses the left common iliac vein against the lumbar spine (Figure 1). This narrowing of the left common iliac vein (LCIV) can cause severe complications in the left lower extremity (LLE), such as swelling, pain, venous reflux disease, and deep vein thrombosis (DVT). Although it was first described in 1851, there are currently no standardized criteria in diagnosing MTS. Not only is sonography a useful tool in the discovery of DVT, but it also has an ongoing role in patients with venous ulcerations and chronic edema, which can cause lifestyle limitations in patients with postphlebitis syndrome. Case Study A woman late in her fourth decade presented to her vascular physician complaining of LLE varicose veins, achiness, fatigue, and swelling. Three years earlier, she was diagnosed with LLE DVT in an emergency department and was treated with an inferior vena cava (IVC) filter. This was reportedly because she was not a candidate for anticoagulation due to a history of a ruptured stomach ulcer. It is unfortunate that the patient did not follow up with her vascular physician after her initial DVT diagnosis until the LLE symptoms became severe. She did not have any indication of coagulation abnormalities. A bilateral lower extremity venous reflux sonogram and IVC sonogram were ordered. A linear transducer with a center frequency of 9 MHz was used on a Philips iU22 system (Philips Healthcare, Andover, MA) to perform the 714796J DMXXX10.