Venom Component Allergen IgE Measurement in the Diagnosis and Management of Insect Sting Allergy

Blank, Simon; Korošec, Peter; Slusarenko, Benjamin O.; Ollert, Markus; Hamilton, Robert G.

doi:10.1016/j.jaip.2024.07.023

The Journal of Allergy and Clinical Immunology: In Practice

2024

DOI: 10.1016/j.jaip.2024.07.023

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Venom Component Allergen IgE Measurement in the Diagnosis and Management of Insect Sting Allergy

Simon Blank,

Peter Korošec,

Benjamin O. Slusarenko

et al.

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2024

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Cited by 1 publication

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Comparative Assessment of the Allergenicity of Hyaluronidases from Polistes dominula (Pol d 2), Vespula vulgaris (Ves v 2), and Apis mellifera Venom (Api m 2)

Grosch,

Eberlein,

Waldherr

et al. 2024

Toxins

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Sensitization to cross-reactive allergens complicates identifying the culprit insect in Hymenoptera venom allergy via diagnostic tests. This study evaluates sensitization to hyaluronidases (Api m 2 from honey bee (Apis mellifera) venom, HBV; Pol d 2 from European paper wasp (Polistes dominula) venom, PDV; and Ves v 2.0101 and Ves v 2.0201 from yellow jacket (Vespula vulgaris) venom, YJV) and their cross-reactivity in allergic patients from Italy, Spain, and Germany using ImmunoCAPs, ELISA, and basophil activation tests. Sensitization rates were 45% for Api m 2 in HBV-allergic subjects, 25% for Pol d 2 in PDV-allergic individuals, and 20% and 10% for Ves v 2.0201 and Ves v 2.0101 in YJV-allergic patients, respectively. Patients primarily sensitized to Api m 2 showed minimal cross-reactivity to vespid hyaluronidases, whereas those primarily sensitized to Pol d 2 or Ves v 2.0201 exhibited IgE reactivity to Api m 2. Neither Pol d 2 nor Ves v 2.0201 triggered basophil activation. Cross-reactivity of Api m 2, Pol d 2, and Ves v 2.0201 depends on the primary sensitizing venom. Sensitization to Pol d 2 and Ves v 2.0201 remains below 25%, yet these patients may exhibit cross-reactivity to Api m 2. Conversely, HBV-allergic patients sensitized to Api m 2 show minimal reactivity to Pol d 2 or Ves v 2.0201.

show abstract

Comparative Assessment of the Allergenicity of Hyaluronidases from Polistes dominula (Pol d 2), Vespula vulgaris (Ves v 2), and Apis mellifera Venom (Api m 2)

Grosch,

Eberlein,

Waldherr

et al. 2024

Toxins

View full text Add to dashboard Cite

show abstract

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Venom Component Allergen IgE Measurement in the Diagnosis and Management of Insect Sting Allergy

Cited by 1 publication

References 107 publications

Comparative Assessment of the Allergenicity of Hyaluronidases from Polistes dominula (Pol d 2), Vespula vulgaris (Ves v 2), and Apis mellifera Venom (Api m 2)

Comparative Assessment of the Allergenicity of Hyaluronidases from Polistes dominula (Pol d 2), Vespula vulgaris (Ves v 2), and Apis mellifera Venom (Api m 2)

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